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Molecular and Cellular Biology, January 2001, p. 281-288, Vol. 21, No. 1
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.1.281-288.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

DNA Damage-Dependent Nuclear Dynamics of the Mre11 Complex†

Olga K. Mirzoeva and John H. J. Petrini*

Laboratory of Genetics, University of Wisconsin Medical School, Madison, Wisconsin 53706

Received 20 July 2000/Returned for modification 28 August 2000/Accepted 10 October 2000

The Mre11 complex has been implicated in diverse aspects of the cellular response to DNA damage. We used in situ fractionation of human fibroblasts to carry out cytologic analysis of Mre11 complex proteins in the double-strand break (DSB) response. In situ fractionation removes most nucleoplasmic protein, permitting immunofluorescent localization of proteins that become more avidly bound to nuclear structures after induction of DNA damage. We found that a fraction of the Mre11 complex was bound to promyelocyte leukemia protein bodies in undamaged cells. Within 10 min after gamma irradiation, nuclear retention of the Mre11 complex in small granular foci was observed and persisted until 2 h postirradiation. In light of the previous demonstration that the Mre11 complex associated with ionizing radiation (IR)-induced DSBs, we infer that the protein retained under these conditions was associated with DNA damage. We also observed increased retention of Rad51 following IR treatment, although IR induced Rad51 foci were distinct from Mre11 foci. The ATM kinase, which phosphorylates Nbs1 during activation of the S-phase checkpoint, was not required for the Mre11 complex to associate with DNA damage. These data suggest that the functions of the Mre11 complex in the DSB response are implicitly dependent upon its ability to detect DNA damage.

* Corresponding author. Mailing address: Laboratory of Genetics, University of Wisconsin Medical School, 445 Henry Mall, Madison, WI 53706. Phone: (608) 265-6043. Fax: (608) 262-2976. E-mail: jpetrini{at}facstaff.wisc.edu.

dagger Report 3564 from the University of Wisconsin-Madison Laboratory of Genetics.

Molecular and Cellular Biology, January 2001, p. 281-288, Vol. 21, No. 1
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.1.281-288.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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  • Li, S., Takeda, Y., Wragg, S., Barrett, J., Phillips, A., Dynan, W. S. (2003). Modification of the ionizing radiation response in living cells by an scFv against the DNA-dependent protein kinase. Nucleic Acids Res 31: 5848-5857 [Abstract] [Full Text]  
  • Mieczkowski, P. A., Mieczkowska, J. O., Dominska, M., Petes, T. D. (2003). Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae. Proc. Natl. Acad. Sci. USA 100: 10854-10859 [Abstract] [Full Text]  
  • Nakada, D., Matsumoto, K., Sugimoto, K. (2003). ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism. Genes Dev. 17: 1957-1962 [Abstract] [Full Text]  
  • Lee, J. H., Xu, B., Lee, C.-H., Ahn, J.-Y., Song, M. S., Lee, H., Canman, C. E., Lee, J.-S., Kastan, M. B., Lim, D.-S. (2003). Distinct Functions of Nijmegen Breakage Syndrome in Ataxia Telangiectasia Mutated-Dependent Responses to DNA Damage. Mol Cancer Res 1: 674-681 [Abstract] [Full Text]  
  • Xu, Z.-X., Timanova-Atanasova, A., Zhao, R.-X., Chang, K.-S. (2003). PML Colocalizes with and Stabilizes the DNA Damage Response Protein TopBP1. Mol. Cell. Biol. 23: 4247-4256 [Abstract] [Full Text]  
  • Cerosaletti, K. M., Concannon, P. (2003). Nibrin Forkhead-associated Domain and Breast Cancer C-terminal Domain Are Both Required for Nuclear Focus Formation and Phosphorylation. J. Biol. Chem. 278: 21944-21951 [Abstract] [Full Text]  
  • Wu, G., Jiang, X., Lee, W.-H., Chen, P.-L. (2003). Assembly of Functional ALT-associated Promyelocytic Leukemia Bodies Requires Nijmegen Breakage Syndrome 1. Cancer Res. 63: 2589-2595 [Abstract] [Full Text]  
  • Liu, K., Lin, F.-T., Ruppert, J. M., Lin, W.-C. (2003). Regulation of E2F1 by BRCT Domain-Containing Protein TopBP1. Mol. Cell. Biol. 23: 3287-3304 [Abstract] [Full Text]  
  • Hassane, D. C., Lee, R. B., Pickett, C. L. (2003). Campylobacter jejuni Cytolethal Distending Toxin Promotes DNA Repair Responses in Normal Human Cells. Infect. Immun. 71: 541-545 [Abstract] [Full Text]  
  • Mirzoeva, O. K., Petrini, J. H.J. (2003). DNA Replication-Dependent Nuclear Dynamics of the Mre11 Complex. Mol Cancer Res 1: 207-218 [Abstract] [Full Text]  
  • Richie, C. T., Peterson, C., Lu, T., Hittelman, W. N., Carpenter, P. B., Legerski, R. J. (2002). hSnm1 Colocalizes and Physically Associates with 53BP1 before and after DNA Damage. Mol. Cell. Biol. 22: 8635-8647 [Abstract] [Full Text]  
  • Kim, J.-S., Krasieva, T. B., LaMorte, V., Taylor, A. M. R., Yokomori, K. (2002). Specific Recruitment of Human Cohesin to Laser-induced DNA Damage. J. Biol. Chem. 277: 45149-45153 [Abstract] [Full Text]  
  • Pichierri, P., Averbeck, D., Rosselli, F. (2002). DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein. Hum Mol Genet 11: 2531-2546 [Abstract] [Full Text]  
  • Bender, C. F., Sikes, M. L., Sullivan, R., Huye, L. E., Le Beau, M. M., Roth, D. B., Mirzoeva, O. K., Oltz, E. M., Petrini, J. H. J. (2002). Cancer predisposition and hematopoietic failure in Rad50S/S mice. Genes Dev. 16: 2237-2251 [Abstract] [Full Text]  
  • Rouse, J., Jackson, S. P. (2002). Interfaces Between the Detection, Signaling, and Repair of DNA Damage. Science 297: 547-551 [Abstract] [Full Text]  
  • Robinson, N. P., McCulloch, R., Conway, C., Browitt, A., Barry, J. D. (2002). Inactivation of Mre11 Does Not Affect VSG Gene Duplication Mediated by Homologous Recombination in Trypanosoma brucei. J. Biol. Chem. 277: 26185-26193 [Abstract] [Full Text]  
  • Franchitto, A., Pichierri, P. (2002). Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest. JCB 157: 19-30 [Abstract] [Full Text]  
  • Grandi, P., Eltsov, M., Nielsen, I., Raska, I. (2002). DNA double-strand breaks induce formation of RP-A/Ku foci on in vitro reconstituted Xenopus sperm nuclei. J. Cell Sci. 114: 3345-3357 [Abstract] [Full Text]  
  • Yazdi, P. T., Wang, Y., Zhao, S., Patel, N., Lee, E. Y.-H.P., Qin, J. (2002). SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev. 16: 571-582 [Abstract] [Full Text]  
  • Huang, J., Dynan, W. S. (2002). Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction. Nucleic Acids Res 30: 667-674 [Abstract] [Full Text]  
  • Yamane, K., Wu, X., Chen, J. (2002). A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival. Mol. Cell. Biol. 22: 555-566 [Abstract] [Full Text]  
  • Maser, R. S., Mirzoeva, O. K., Wells, J., Olivares, H., Williams, B. R., Zinkel, R. A., Farnham, P. J., Petrini, J. H. J. (2001). Mre11 Complex and DNA Replication: Linkage to E2F and Sites of DNA Synthesis. Mol. Cell. Biol. 21: 6006-6016 [Abstract] [Full Text]  
  • Gasior, S. L., Olivares, H., Ear, U., Hari, D. M., Weichselbaum, R., Bishop, D. K. (2001). Assembly of RecA-like recombinases: Distinct roles for mediator proteins in mitosis and meiosis. Proc. Natl. Acad. Sci. USA 98: 8411-8418 [Abstract] [Full Text]  
  • Parvin, J. D. (2001). BRCA1 at a branch point. Proc. Natl. Acad. Sci. USA 98: 5952-5954 [Full Text]  
  • Yannone, S. M., Roy, S., Chan, D. W., Murphy, M. B., Huang, S., Campisi, J., Chen, D. J. (2001). Werner Syndrome Protein Is Regulated and Phosphorylated by DNA-dependent Protein Kinase. J. Biol. Chem. 276: 38242-38248 [Abstract] [Full Text]  
  • Andegeko, Y., Moyal, L., Mittelman, L., Tsarfaty, I., Shiloh, Y., Rotman, G. (2001). Nuclear Retention of ATM at Sites of DNA Double Strand Breaks. J. Biol. Chem. 276: 38224-38230 [Abstract] [Full Text]  
  • Limoli, C. L., Giedzinski, E., Bonner, W. M., Cleaver, J. E. (2002). UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization. Proc. Natl. Acad. Sci. USA 99: 233-238 [Abstract] [Full Text]  
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