B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune Responses

doi:10.1128/MCB.21.12.4067-4074.2001

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Molecular and Cellular Biology, June 2001, p. 4067-4074, Vol. 21, No. 12
0270-7306/01/$04.00+0 DOI: 10.1128/MCB.21.12.4067-4074.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune Responses

Shengli Xu and Kong-Peng Lam^*

Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore

Received 18 January 2001/Returned for modification 28 February 2001/Accepted 20 March 2001

B-cell maturation protein (BCMA) is a member of the tumor necrosis factor (TNF) receptor family and is expressed in B lymphocytes.BCMA binds two TNF family members, BAFF and APRIL, that stimulatecellular proliferation. BAFF in particular has been shown to influenceB-cell survival and activation, and transgenic mice overexpressingBAFF have a lupus-like autoimmune disorder. We have inactivatedBCMA in the mouse germ line. BCMA^/ mice have normal B-cell development, and the life span of mutantB lymphocytes is comparable to that of wild-type B cells. Thehumoral immune responses of BCMA^/ mice to T-cell-independent antigens as well as high and low dosesof T-cell-dependent antigens are also intact. In addition, mutantmice have normal splenic architecture, and germinal centers areformed during an ongoing immune response. These data suggest afunctional redundancy of BCMA in B-cell physiology that is probablydue to the presence of TACI, another TNF receptor family memberthat is expressed on B cells and that can also bind BAFF andAPRIL.

^* Corresponding author. Mailing address: Institute of Molecular and Cell Biology, 30 Medical Dr., Singapore 117609, Republicof Singapore. Phone: (65) 874 3784. Fax: (65) 779 1117. E-mail:mcblamkp{at}imcb.nus.edu.sg.

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