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Molecular and Cellular Biology, July 2001, p. 4399-4403, Vol. 21, No. 13
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.13.4399-4403.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Mice Lacking the Nkx6.2 (Gtx) Homeodomain Transcription Factor Develop and Reproduce Normally

Jun Cai, Yingchuan Qi, Rui Wu, Geoffrey Modderman, Hui Fu, Rugao Liu, and Mengsheng Qiu*

Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, Kentucky 40292

Received 5 February 2001/Accepted 23 March 2001

The Nkx homeobox genes are expressed in a variety of developing tissues and have been implicated in controlling tissue patterning and cell differentiation. Expression of Nkx6.2 (Gtx) was previously observed in the embryonic neural tube, testis, and differentiating oligodendrocytes. To investigate the role of Nkx6.2 in the control of cell specification and differentiation, we generated mice with null mutations in Nkx6.2 using the standard gene targeting approach. Null mutant mice were viable and fertile without apparent histological and immunohistochemical changes in the central nervous systems and testis. The absence of detectable phenotypes suggests a redundant function of Nkx6.2 in mouse development.

* Corresponding author. Mailing address: Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292. Phone: (502) 852-7502. Fax: (502) 852-6228. E-mail: m0qiu001{at}louisville.edu.

Molecular and Cellular Biology, July 2001, p. 4399-4403, Vol. 21, No. 13
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.13.4399-4403.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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