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Molecular and Cellular Biology, July 2001, p. 4684-4699, Vol. 21, No. 14
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.14.4684-4699.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Role for E2F in Control of Both DNA Replication and Mitotic Functions as Revealed from DNA Microarray Analysis

Seiichi Ishida,1 Erich Huang,1 Harry Zuzan,2 Rainer Spang,2 Gustavo Leone,1,dagger Mike West,2 and Joseph R. Nevins1,*

Department of Genetics and Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 277101 and Institute of Statistics and Decision Sciences, Duke University, Durham, North Carolina 277082

Received 8 January 2001/Returned for modification 1 February 2001/Accepted 26 April 2001

We have used high-density DNA microarrays to provide an analysis of gene regulation during the mammalian cell cycle and the role of E2F in this process. Cell cycle analysis was facilitated by a combined examination of gene control in serum-stimulated fibroblasts and cells synchronized at G1/S by hydroxyurea block that were then released to proceed through the cell cycle. The latter approach (G1/S synchronization) is critical for rigorously maintaining cell synchrony for unambiguous analysis of gene regulation in later stages of the cell cycle. Analysis of these samples identified seven distinct clusters of genes that exhibit unique patterns of expression. Genes tend to cluster within these groups based on common function and the time during the cell cycle that the activity is required. Placed in this context, the analysis of genes induced by E2F proteins identified genes or expressed sequence tags not previously described as regulated by E2F proteins; surprisingly, many of these encode proteins known to function during mitosis. A comparison of the E2F-induced genes with the patterns of cell growth-regulated gene expression revealed that virtually all of the E2F-induced genes are found in only two of the cell cycle clusters; one group was regulated at G1/S, and the second group, which included the mitotic activities, was regulated at G2. The activation of the G2 genes suggests a broader role for E2F in the control of both DNA replication and mitotic activities.

* Corresponding author. Mailing address: Department of Genetics, Duke University Medical Center, Durham, NC 27710. Phone: (919) 684-2746. Fax: (919) 681-8973. E-mail: J.Nevins{at}duke.edu.

dagger Present address: Division of Human Cancer Genetics, Ohio State University, Columbus, OH 43210.

Molecular and Cellular Biology, July 2001, p. 4684-4699, Vol. 21, No. 14
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.14.4684-4699.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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  • Bosco, E. E., Mayhew, C. N., Hennigan, R. F., Sage, J., Jacks, T., Knudsen, E. S. (2004). RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult. Nucleic Acids Res 32: 25-34 [Abstract] [Full Text]  
  • Sola, S., Ma, X., Castro, R. E., Kren, B. T., Steer, C. J., Rodrigues, C. M. P. (2003). Ursodeoxycholic Acid Modulates E2F-1 and p53 Expression through a Caspase-independent Mechanism in Transforming Growth Factor {beta}1-induced Apoptosis of Rat Hepatocytes. J. Biol. Chem. 278: 48831-48838 [Abstract] [Full Text]  
  • Herceg, Z., Li, H., Cuenin, C., Shukla, V., Radolf, M., Steinlein, P., Wang, Z.-Q. (2003). Genome-wide analysis of gene expression regulated by the HAT cofactor Trrap in conditional knockout cells. Nucleic Acids Res 31: 7011-7023 [Abstract] [Full Text]  
  • Brake, T., Connor, J. P., Petereit, D. G., Lambert, P. F. (2003). Comparative Analysis of Cervical Cancer in Women and in a Human Papillomavirus-Transgenic Mouse Model: Identification of Minichromosome Maintenance Protein 7 as an Informative Biomarker for Human Cervical Cancer. Cancer Res. 63: 8173-8180 [Abstract] [Full Text]  
  • Coser, K. R., Chesnes, J., Hur, J., Ray, S., Isselbacher, K. J., Shioda, T. (2003). Global analysis of ligand sensitivity of estrogen inducible and suppressible genes in MCF7/BUS breast cancer cells by DNA microarray. Proc. Natl. Acad. Sci. USA 100: 13994-13999 [Abstract] [Full Text]  
  • Vernell, R., Helin, K., Muller, H. (2003). Identification of Target Genes of the p16INK4A-pRB-E2F Pathway. J. Biol. Chem. 278: 46124-46137 [Abstract] [Full Text]  
  • Zhao, H., Granberg, F., Elfineh, L., Pettersson, U., Svensson, C. (2003). Strategic Attack on Host Cell Gene Expression during Adenovirus Infection. J. Virol. 77: 11006-11015 [Abstract] [Full Text]  
  • Vlieghe, K., Vuylsteke, M., Florquin, K., Rombauts, S., Maes, S., Ormenese, S., Van Hummelen, P., Van de Peer, Y., Inze, D., De Veylder, L. (2003). Microarray analysis of E2Fa-DPa-overexpressing plants uncovers a cross-talking genetic network between DNA replication and nitrogen assimilation. J. Cell Sci. 116: 4249-4259 [Abstract] [Full Text]  
  • Dimova, D. K., Stevaux, O., Frolov, M. V., Dyson, N. J. (2003). Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. Genes Dev. 17: 2308-2320 [Abstract] [Full Text]  
  • Lohr, K., Moritz, C., Contente, A., Dobbelstein, M. (2003). p21/CDKN1A Mediates Negative Regulation of Transcription by p53. J. Biol. Chem. 278: 32507-32516 [Abstract] [Full Text]  
  • Di Fiore, B., Ciciarello, M., Mangiacasale, R., Palena, A., Tassin, A.-M., Cundari, E., Lavia, P. (2003). Mammalian RanBP1 regulates centrosome cohesion during mitosis. J. Cell Sci. 116: 3399-3411 [Abstract] [Full Text]  
  • Kosugi, S., Ohashi, Y. (2003). Constitutive E2F Expression in Tobacco Plants Exhibits Altered Cell Cycle Control and Morphological Change in a Cell Type-Specific Manner. Plant Physiol. 132: 2012-2022 [Abstract] [Full Text]  
  • Fay, D. S., Large, E., Han, M., Darland, M. (2003). lin-35/Rb and ubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control pharyngeal morphogenesis in C. elegans. Development 130: 3319-3330 [Abstract] [Full Text]  
  • Black, E. P., Huang, E., Dressman, H., Rempel, R., Laakso, N., Asa, S. L., Ishida, S., West, M., Nevins, J. R. (2003). Distinct Gene Expression Phenotypes of Cells Lacking Rb and Rb Family Members. Cancer Res. 63: 3716-3723 [Abstract] [Full Text]  
  • Ma, Y., Yuan, J., Huang, M., Jove, R., Cress, W. D. (2003). Regulation of the Cyclin D3 Promoter by E2F1. J. Biol. Chem. 278: 16770-16776 [Abstract] [Full Text]  
  • Elkon, R., Linhart, C., Sharan, R., Shamir, R., Shiloh, Y. (2003). Genome-Wide In Silico Identification of Transcriptional Regulators Controlling the Cell Cycle in Human Cells. Genome Res 13: 773-780 [Abstract] [Full Text]  


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