The TFIID Components Human TAFII140 and Drosophila BIP2 (TAFII155) Are Novel Metazoan Homologues of Yeast TAFII47 Containing a Histone Fold and a PHD Finger

doi:10.1128/MCB.21.15.5109-5121.2001

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Molecular and Cellular Biology, August 2001, p. 5109-5121, Vol. 21, No. 15
0270-7306/01/$04.00+0 DOI: 10.1128/MCB.21.15.5109-5121.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

The TFIID Components Human TAF_II140 and Drosophila BIP2 (TAF_II155) Are Novel Metazoan Homologues of Yeast TAF_II47 Containing a Histone Fold and a PHD Finger

Yann-Gaël Gangloff,¹ Jean-Christophe Pointud,² Sylvie Thuault,¹ Lucie Carré,¹ Christophe Romier,¹ Selen Muratoglu,³ Marjorie Brand,¹ Laszlo Tora,¹ Jean-Louis Couderc,² and Irwin Davidson¹^,^*

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, 67404 Illkirch Cédex, C.U. de Strasbourg,¹ and Institut National de la Santé et de la Recherche Médicale U384, Laboratoire de Biochimie, UFR Médecine, 63001 Clermont-Ferrand,² France, and Institute of Biochemistry, Biological Research Center, Szeged 6701, Hungary³

Received 25 January 2001/Returned for modification 26 February 2001/Accepted 28 April 2001

The RNA polymerase II transcription factor TFIID comprises the TATA binding protein (TBP) and a set of TBP-associated factors(TAF_IIs). TFIID has been extensively characterized for yeast,Drosophila, and humans, demonstrating a high degree of conservationof both the amino acid sequences of the constituent TAF_IIs andoverall molecular organization. In recent years, it has been assumedthat all the metazoan TAF_IIs have been identified, yet no metazoanhomologues of yeast TAF_II47 (yTAF_II47) and yTAF_II65 are known.Both of these yTAF_IIs contain a histone fold domain (HFD) whichselectively heterodimerizes with that of yTAF_II25. We have cloneda novel mouse protein, TAF_II140, containing an HFD and a planthomeodomain (PHD) finger, which we demonstrated by immunoprecipitationto be a mammalian TFIID component. TAF_II140 shows extensive sequencesimilarity to Drosophila BIP2 (dBIP2) (dTAF_II155), which we alsoshow to be a component of Drosophila TFIID. These proteins aremetazoan homologues of yTAF_II47 as their HFDs selectively heterodimerizewith dTAF_II24 and human TAF_II30, metazoan homologues of yTAF_II25.We further show that yTAF_II65 shares two domains with the DrosophilaProdos protein, a recently described potential dTAF_II. These conserveddomains are critical for yTAF_II65 function in vivo. Our resultstherefore identify metazoan homologues of yTAF_II47 and yTAF_II65.

^* Corresponding author. Mailing address: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP,BP 163, 67404 Illkirch Cédex, C.U. de Strasbourg, France. Phone:33 3 88 65 34 40 (45). Fax: 33 3 88 65 32 01. E-mail: irwin{at}titus.u-strasbg.fr.

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