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Molecular and Cellular Biology, August 2001, p. 5306-5311, Vol. 21, No. 16
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.16.5306-5311.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Functional Analysis of Mouse Kinesin Motor Kif3C

Zhaohuai Yang,dagger Elizabeth A. Roberts, and Lawrence S. B. Goldstein*

Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California 92093

Received 26 February 2001/Returned for modification 16 April 2001/Accepted 30 May 2001

Members of the kinesin II family are thought to play essential roles in many types of intracellular transport. One distinguishing feature of kinesin II is that it generally contains two different motor subunits from the Kif3 family. Three Kif3 family members (Kif3A, Kif3B, and Kif3C) have been identified and characterized in mice. Intracellular localization and biochemical studies previously suggested that Kif3C is an anterograde motor involved in anterograde axonal transport. To understand the in vivo function of the Kif3C gene, we used homologous recombination in embryonic stem cells to construct two different knockout mouse strains for the Kif3C gene. Both homozygous Kif3C mutants are viable, reproduce normally, and apparently develop normally. These results suggest that Kif3C is dispensable for normal neural development and behavior in the mouse.

* Corresponding author. Mailing address: HHMI/CMM Room 336, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0683. Phone: (858) 534-9702. Fax: (858) 534-9701. E-mail: lgoldstein{at}ucsd.edu.

dagger Present address: Aviva Biosciences, San Diego, CA 92121.

Molecular and Cellular Biology, August 2001, p. 5306-5311, Vol. 21, No. 16
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.16.5306-5311.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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