This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Guenther, M. G.
Right arrow Articles by Lazar, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Guenther, M. G.
Right arrow Articles by Lazar, M. A.

Next Article 

Molecular and Cellular Biology, September 2001, p. 6091-6101, Vol. 21, No. 18
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.18.6091-6101.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

The SMRT and N-CoR Corepressors Are Activating Cofactors for Histone Deacetylase 3

Matthew G. Guenther, Orr Barak, and Mitchell A. Lazar*

Division of Endocrinology, Diabetes, and Metabolism, Departments of Medicine and Genetics, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104

Received 8 March 2001/Returned for modification 30 April 2001/Accepted 21 June 2001

Repression of gene transcription is linked to regulation of chromatin structure through deacetylation of core histone amino-terminal tails. This action is mediated by histone deacetylases (HDACs) that function within active multiprotein complexes directed to the promoters of repressed genes. In vivo, HDAC3 forms a stable complex with the SMRT corepressor. The SMRT-HDAC3 complex exhibits histone deacetylase activity, whereas recombinant HDAC3 is an inactive enzyme. Here we report that SMRT functions as an activating cofactor of HDAC3. In contrast, SMRT does not activate the class II HDAC4, with which it also interacts. Activation of HDAC3 is mediated by a deacetylase activating domain (DAD) that includes one of two SANT motifs present in SMRT. A cognate DAD is present in the related corepressor N-CoR, which can also activate HDAC3. Mutations in the DAD that abolish HDAC3 interaction also eliminate reconstitution of HDAC activity. Using purified components, the SMRT DAD is shown to be necessary and sufficient for activation of HDAC3. Moreover, the DAD is required both for HDAC3 to function enzymatically and for the major repression function of SMRT. Thus, SMRT and N-CoR do not serve merely as platforms for HDAC recruitment but function as an integral component of an active cellular HDAC3 enzyme.

* Corresponding author. Mailing address: University of Pennsylvania School of Medicine, 611 CRB, 415 Curie Blvd., Philadelphia, PA 19104-6149. Phone: (215) 898-0198. Fax: (215) 898-5408. E-mail: lazar{at}mail.med.upenn.edu.

Molecular and Cellular Biology, September 2001, p. 6091-6101, Vol. 21, No. 18
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.18.6091-6101.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Ghoshal, P., Nganga, A. J., Moran-Giuati, J., Szafranek, A., Johnson, T. R., Bigelow, A. J., Houde, C. M., Avet-Loiseau, H., Smiraglia, D. J., Ersing, N., Chanan-Khan, A. A., Coignet, L. J. (2009). Loss of the SMRT/NCoR2 Corepressor Correlates with JAG2 Overexpression in Multiple Myeloma. Cancer Res. 69: 4380-4387 [Abstract] [Full Text]  
  • Pinskaya, M., Nair, A., Clynes, D., Morillon, A., Mellor, J. (2009). Nucleosome Remodeling and Transcriptional Repression Are Distinct Functions of Isw1 in Saccharomyces cerevisiae. Mol. Cell. Biol. 29: 2419-2430 [Abstract] [Full Text]  
  • Jacobs, F. M. J., van Erp, S., van der Linden, A. J. A., von Oerthel, L., Burbach, J. P. H., Smidt, M. P. (2009). Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. Development 136: 531-540 [Abstract] [Full Text]  
  • Lin, Z., Bazzaro, M., Wang, M.-C., Chan, K. C., Peng, S., Roden, R. B.S. (2009). Combination of Proteasome and HDAC Inhibitors for Uterine Cervical Cancer Treatment. Clin. Cancer Res. 15: 570-577 [Abstract] [Full Text]  
  • Astapova, I., Lee, L. J., Morales, C., Tauber, S., Bilban, M., Hollenberg, A. N. (2008). The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo. Proc. Natl. Acad. Sci. USA 105: 19544-19549 [Abstract] [Full Text]  
  • Badri, K. R., Zhou, Y., Dhru, U., Aramgam, S., Schuger, L. (2008). Effects of the SANT Domain of Tension-Induced/Inhibited Proteins (TIPs), Novel Partners of the Histone Acetyltransferase p300, on p300 Activity and TIP-6-Induced Adipogenesis. Mol. Cell. Biol. 28: 6358-6372 [Abstract] [Full Text]  
  • Stanya, K. J., Liu, Y., Means, A. R., Kao, H.-Y. (2008). Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT. JCB 183: 49-61 [Abstract] [Full Text]  
  • Song, L.-N., Gelmann, E. P. (2008). Silencing Mediator for Retinoid and Thyroid Hormone Receptor and Nuclear Receptor Corepressor Attenuate Transcriptional Activation by the {beta}-Catenin-TCF4 Complex. J. Biol. Chem. 283: 25988-25999 [Abstract] [Full Text]  
  • Ishii, S., Kurasawa, Y., Wong, J., Yu-Lee, L.-y. (2008). Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment. Proc. Natl. Acad. Sci. USA 105: 4179-4184 [Abstract] [Full Text]  
  • Lahm, A., Paolini, C., Pallaoro, M., Nardi, M. C., Jones, P., Neddermann, P., Sambucini, S., Bottomley, M. J., Lo Surdo, P., Carfi, A., Koch, U., De Francesco, R., Steinkuhler, C., Gallinari, P. (2007). Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases. Proc. Natl. Acad. Sci. USA 104: 17335-17340 [Abstract] [Full Text]  
  • Ting, H.-J., Bao, B.-Y., Reeder, J. E., Messing, E. M., Lee, Y.-F. (2007). Increased Expression of Corepressors in Aggressive Androgen-Independent Prostate Cancer Cells Results in Loss of 1{alpha},25-Dihydroxyvitamin D3 Responsiveness. Mol Cancer Res 5: 967-980 [Abstract] [Full Text]  
  • Peterson, T. J., Karmakar, S., Pace, M. C., Gao, T., Smith, C. L. (2007). The Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor (SMRT) Corepressor Is Required for Full Estrogen Receptor {alpha} Transcriptional Activity. Mol. Cell. Biol. 27: 5933-5948 [Abstract] [Full Text]  
  • Jonas, B. A., Varlakhanova, N., Hayakawa, F., Goodson, M., Privalsky, M. L. (2007). Response of SMRT (Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor) and N-CoR (Nuclear Receptor Corepressor) Corepressors to Mitogen-Activated Protein Kinase Kinase Kinase Cascades Is Determined by Alternative mRNA Splicing. Mol. Endocrinol. 21: 1924-1939 [Abstract] [Full Text]  
  • Fu, J., Yoon, H.-G., Qin, J., Wong, J. (2007). Regulation of P-TEFb Elongation Complex Activity by CDK9 Acetylation. Mol. Cell. Biol. 27: 4641-4651 [Abstract] [Full Text]  
  • Yan, J., Gao, Z., Yu, G., He, Q., Weng, J., Ye, J. (2007). Nuclear Corepressor Is Required for Inhibition of Phosphoenolpyruvate Carboxykinase Expression by Tumor Necrosis Factor-{alpha}. Mol. Endocrinol. 21: 1630-1641 [Abstract] [Full Text]  
  • Hoshino, H., Nishino, T. G., Tashiro, S., Miyazaki, M., Ohmiya, Y., Igarashi, K., Horinouchi, S., Yoshida, M. (2007). Co-repressor SMRT and Class II Histone Deacetylases Promote Bach2 Nuclear Retention and Formation of Nuclear Foci that are Responsible for Local Transcriptional Repression. J Biochem 141: 719-727 [Abstract] [Full Text]  
  • Matsushita, A., Sasaki, S., Kashiwabara, Y., Nagayama, K., Ohba, K., Iwaki, H., Misawa, H., Ishizuka, K., Nakamura, H. (2007). Essential Role of GATA2 in the Negative Regulation of Thyrotropin {beta} Gene by Thyroid Hormone and Its Receptors. Mol. Endocrinol. 21: 865-884 [Abstract] [Full Text]  
  • Jeyakumar, M., Liu, X.-f., Erdjument-Bromage, H., Tempst, P., Bagchi, M. K. (2007). Phosphorylation of Thyroid Hormone Receptor-associated Nuclear Receptor Corepressor Holocomplex by the DNA-dependent Protein Kinase Enhances Its Histone Deacetylase Activity. J. Biol. Chem. 282: 9312-9322 [Abstract] [Full Text]  
  • Gregoire, S., Xiao, L., Nie, J., Zhang, X., Xu, M., Li, J., Wong, J., Seto, E., Yang, X.-J. (2007). Histone Deacetylase 3 Interacts with and Deacetylates Myocyte Enhancer Factor 2. Mol. Cell. Biol. 27: 1280-1295 [Abstract] [Full Text]  
  • Ohnuma-Ishikawa, K., Morio, T., Yamada, T., Sugawara, Y., Ono, M., Nagasawa, M., Yasuda, A., Morimoto, C., Ohnuma, K., Dang, N. H., Hosoi, H., Verdin, E., Mizutani, S. (2007). Knockdown of XAB2 Enhances All-Trans Retinoic Acid-Induced Cellular Differentiation in All-Trans Retinoic Acid-Sensitive and -Resistant Cancer Cells. Cancer Res. 67: 1019-1029 [Abstract] [Full Text]  
  • Escaffit, F., Vaute, O., Chevillard-Briet, M., Segui, B., Takami, Y., Nakayama, T., Trouche, D. (2007). Cleavage and Cytoplasmic Relocalization of Histone Deacetylase 3 Are Important for Apoptosis Progression. Mol. Cell. Biol. 27: 554-567 [Abstract] [Full Text]  
  • Evert, B. O., Araujo, J., Vieira-Saecker, A. M., de Vos, R. A. I., Harendza, S., Klockgether, T., Wullner, U. (2006). Ataxin-3 Represses Transcription via Chromatin Binding, Interaction with Histone Deacetylase 3, and Histone Deacetylation.. J. Neurosci. 26: 11474-11486 [Abstract] [Full Text]  
  • Yu, J., Palmer, C., Alenghat, T., Li, Y., Kao, G., Lazar, M. A. (2006). The corepressor silencing mediator for retinoid and thyroid hormone receptor facilitates cellular recovery from DNA double-strand breaks.. Cancer Res. 66: 9316-9322 [Abstract] [Full Text]  
  • Li, Y., Kao, G. D., Garcia, B. A., Shabanowitz, J., Hunt, D. F., Qin, J., Phelan, C., Lazar, M. A. (2006). A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Genes Dev. 20: 2566-2579 [Abstract] [Full Text]  
  • Lee, M. G., Wynder, C., Bochar, D. A., Hakimi, M.-A., Cooch, N., Shiekhattar, R. (2006). Functional Interplay between Histone Demethylase and Deacetylase Enzymes.. Mol. Cell. Biol. 26: 6395-6402 [Abstract] [Full Text]  
  • Kim, M.-Y., Jeong, B. C., Lee, J. H., Kee, H. J., Kook, H., Kim, N. S., Kim, Y. H., Kim, J.-K., Ahn, K. Y., Kim, K. K. (2006). A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. Proc. Natl. Acad. Sci. USA 103: 13074-13079 [Abstract] [Full Text]  
  • Foglietti, C., Filocamo, G., Cundari, E., De Rinaldis, E., Lahm, A., Cortese, R., Steinkuhler, C. (2006). Dissecting the Biological Functions of Drosophila Histone Deacetylases by RNA Interference and Transcriptional Profiling. J. Biol. Chem. 281: 17968-17976 [Abstract] [Full Text]  
  • Rosenfeld, M. G., Lunyak, V. V., Glass, C. K. (2006). Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes Dev. 20: 1405-1428 [Abstract] [Full Text]  
  • Tiefenbach, J., Novac, N., Ducasse, M., Eck, M., Melchior, F., Heinzel, T. (2006). SUMOylation of the Corepressor N-CoR Modulates Its Capacity to Repress Transcription. Mol. Biol. Cell 17: 1643-1651 [Abstract] [Full Text]  
  • Bates, E. A., Victor, M., Jones, A. K., Shi, Y., Hart, A. C. (2006). Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity.. J. Neurosci. 26: 2830-2838 [Abstract] [Full Text]  
  • Wang, L., Rajan, H., Pitman, J. L., McKeown, M., Tsai, C.-C. (2006). Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors. Genes Dev. 20: 525-530 [Abstract] [Full Text]  
  • Gao, Z., He, Q., Peng, B., Chiao, P. J., Ye, J. (2006). Regulation of Nuclear Translocation of HDAC3 by I{kappa}B{alpha} Is Required for Tumor Necrosis Factor Inhibition of Peroxisome Proliferator-activated Receptor {gamma} Function. J. Biol. Chem. 281: 4540-4547 [Abstract] [Full Text]  
  • Macfarlan, T., Parker, J. B., Nagata, K., Chakravarti, D. (2006). Thanatos-Associated Protein 7 Associates with Template Activating Factor-I{beta} and Inhibits Histone Acetylation to Repress Transcription. Mol. Endocrinol. 20: 335-347 [Abstract] [Full Text]  
  • Liu, F., Pore, N., Kim, M., Voong, K. R., Dowling, M., Maity, A., Kao, G. D. (2006). Regulation of Histone Deacetylase 4 Expression by the SP Family of Transcription Factors. Mol. Biol. Cell 17: 585-597 [Abstract] [Full Text]  
  • Villa, R., Morey, L., Raker, V. A., Buschbeck, M., Gutierrez, A., De Santis, F., Corsaro, M., Varas, F., Bossi, D., Minucci, S., Pelicci, P. G., Di Croce, L. (2006). The methyl-CpG binding protein MBD1 is required for PML-RAR{alpha} function. Proc. Natl. Acad. Sci. USA 103: 1400-1405 [Abstract] [Full Text]  
  • Hoberg, J. E., Popko, A. E., Ramsey, C. S., Mayo, M. W. (2006). I{kappa}B Kinase {alpha}-Mediated Derepression of SMRT Potentiates Acetylation of RelA/p65 by p300. Mol. Cell. Biol. 26: 457-471 [Abstract] [Full Text]  
  • Huanca-Mamani, W., Garcia-Aguilar, M., Leon-Martinez, G., Grossniklaus, U., Vielle-Calzada, J.-P. (2005). CHR11, a chromatin-remodeling factor essential for nuclear proliferation during female gametogenesis in Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA 102: 17231-17236 [Abstract] [Full Text]  
  • Li, D., Yea, S., Li, S., Chen, Z., Narla, G., Banck, M., Laborda, J., Tan, S., Friedman, J. M., Friedman, S. L., Walsh, M. J. (2005). Kruppel-like Factor-6 Promotes Preadipocyte Differentiation through Histone Deacetylase 3-dependent Repression of DLK1. J. Biol. Chem. 280: 26941-26952 [Abstract] [Full Text]  
  • Gao, Z., Chiao, P., Zhang, X., Zhang, X., Lazar, M. A., Seto, E., Young, H. A., Ye, J. (2005). Coactivators and Corepressors of NF-{kappa}B in I{kappa}B{alpha} Gene Promoter. J. Biol. Chem. 280: 21091-21098 [Abstract] [Full Text]  
  • Ishizuka, T., Lazar, M. A. (2005). The Nuclear Receptor Corepressor Deacetylase Activating Domain Is Essential for Repression by Thyroid Hormone Receptor. Mol. Endocrinol. 19: 1443-1451 [Abstract] [Full Text]  
  • Yin, L., Lazar, M. A. (2005). The Orphan Nuclear Receptor Rev-erb{alpha} Recruits the N-CoR/Histone Deacetylase 3 Corepressor to Regulate the Circadian Bmal1 Gene. Mol. Endocrinol. 19: 1452-1459 [Abstract] [Full Text]  
  • Ki, S. H., Cho, I. J., Choi, D. W., Kim, S. G. (2005). Glucocorticoid Receptor (GR)-Associated SMRT Binding to C/EBP{beta} TAD and Nrf2 Neh4/5: Role of SMRT Recruited to GR in GSTA2 Gene Repression. Mol. Cell. Biol. 25: 4150-4165 [Abstract] [Full Text]  
  • Codina, A., Love, J. D., Li, Y., Lazar, M. A., Neuhaus, D., Schwabe, J. W. R. (2005). From The Cover: Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors. Proc. Natl. Acad. Sci. USA 102: 6009-6014 [Abstract] [Full Text]  
  • Zhang, X., Ozawa, Y., Lee, H., Wen, Y.-D., Tan, T.-H., Wadzinski, B. E., Seto, E. (2005). Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. Genes Dev. 19: 827-839 [Abstract] [Full Text]  
  • Yoon, H.-G., Choi, Y., Cole, P. A., Wong, J. (2005). Reading and Function of a Histone Code Involved in Targeting Corepressor Complexes for Repression. Mol. Cell. Biol. 25: 324-335 [Abstract] [Full Text]  
  • Kato, H., Tamamizu-Kato, S., Shibasaki, F. (2004). Histone Deacetylase 7 Associates with Hypoxia-inducible Factor 1{alpha} and Increases Transcriptional Activity. J. Biol. Chem. 279: 41966-41974 [Abstract] [Full Text]  
  • Schroeder, T. M., Kahler, R. A., Li, X., Westendorf, J. J. (2004). Histone Deacetylase 3 Interacts with Runx2 to Repress the Osteocalcin Promoter and Regulate Osteoblast Differentiation. J. Biol. Chem. 279: 41998-42007 [Abstract] [Full Text]  
  • Mahlknecht, U., Will, J., Varin, A., Hoelzer, D., Herbein, G. (2004). Histone Deacetylase 3, a Class I Histone Deacetylase, Suppresses MAPK11-Mediated Activating Transcription Factor-2 Activation and Represses TNF Gene Expression. J. Immunol. 173: 3979-3990 [Abstract] [Full Text]  
  • Malartre, M., Short, S., Sharpe, C. (2004). Alternative splicing generates multiple SMRT transcripts encoding conserved repressor domains linked to variable transcription factor interaction domains. Nucleic Acids Res 32: 4676-4686 [Abstract] [Full Text]  
  • Ding, Z., Gillespie, L. L., Mercer, F. C., Paterno, G. D. (2004). The SANT Domain of Human MI-ER1 Interacts with Sp1 to Interfere with GC Box Recognition and Repress Transcription from Its Own Promoter. J. Biol. Chem. 279: 28009-28016 [Abstract] [Full Text]  
  • Miao, F., Gonzalo, I. G., Lanting, L., Natarajan, R. (2004). In Vivo Chromatin Remodeling Events Leading to Inflammatory Gene Transcription under Diabetic Conditions. J. Biol. Chem. 279: 18091-18097 [Abstract] [Full Text]  
  • Deng, Z., Atanasiu, C., Burg, J. S., Broccoli, D., Lieberman, P. M. (2003). Telomere Repeat Binding Factors TRF1, TRF2, and hRAP1 Modulate Replication of Epstein-Barr Virus OriP. J. Virol. 77: 11992-12001 [Abstract] [Full Text]  
  • Yao, Y.-L., Yang, W.-M. (2003). The Metastasis-associated Proteins 1 and 2 Form Distinct Protein Complexes with Histone Deacetylase Activity. J. Biol. Chem. 278: 42560-42568 [Abstract] [Full Text]  
  • Ishizuka, T., Lazar, M. A. (2003). The N-CoR/Histone Deacetylase 3 Complex Is Required for Repression by Thyroid Hormone Receptor. Mol. Cell. Biol. 23: 5122-5131 [Abstract] [Full Text]  
  • Noh, Y.-S., Amasino, R. M. (2003). PIE1, an ISWI Family Gene, Is Required for FLC Activation and Floral Repression in Arabidopsis. Plant Cell 15: 1671-1682 [Abstract] [Full Text]  
  • Rascle, A., Johnston, J. A., Amati, B. (2003). Deacetylase Activity Is Required for Recruitment of the Basal Transcription Machinery and Transactivation by STAT5. Mol. Cell. Biol. 23: 4162-4173 [Abstract] [Full Text]  
  • Petrie, K., Guidez, F., Howell, L., Healy, L., Waxman, S., Greaves, M., Zelent, A. (2003). The Histone Deacetylase 9 Gene Encodes Multiple Protein Isoforms. J. Biol. Chem. 278: 16059-16072 [Abstract] [Full Text]  
  • Kao, G. D., McKenna, W. G., Guenther, M. G., Muschel, R. J., Lazar, M. A., Yen, T. J. (2003). Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. JCB 160: 1017-1027 [Abstract] [Full Text]  
  • Liao, G., Chen, L.-Y., Zhang, A., Godavarthy, A., Xia, F., Ghosh, J. C., Li, H., Chen, J. D. (2003). Regulation of Androgen Receptor Activity by the Nuclear Receptor Corepressor SMRT. J. Biol. Chem. 278: 5052-5061 [Abstract] [Full Text]  
  • Yamagoe, S., Kanno, T., Kanno, Y., Sasaki, S., Siegel, R. M., Lenardo, M. J., Humphrey, G., Wang, Y., Nakatani, Y., Howard, B. H., Ozato, K. (2003). Interaction of Histone Acetylases and Deacetylases In Vivo. Mol. Cell. Biol. 23: 1025-1033 [Abstract] [Full Text]  
  • Ding, Z., Gillespie, L. L., Paterno, G. D. (2003). Human MI-ER1 Alpha and Beta Function as Transcriptional Repressors by Recruitment of Histone Deacetylase 1 to Their Conserved ELM2 Domain. Mol. Cell. Biol. 23: 250-258 [Abstract] [Full Text]  
  • Sachs, L. M., Jones, P. L., Havis, E., Rouse, N., Demeneix, B. A., Shi, Y.-B. (2002). Nuclear Receptor Corepressor Recruitment by Unliganded Thyroid Hormone Receptor in Gene Repression during Xenopus laevis Development. Mol. Cell. Biol. 22: 8527-8538 [Abstract] [Full Text]  
  • Liu, M., Guo, A., Boukhgalter, B., Van Den Heuvel, K., Tripp, M., Pape, L. (2002). Characterization of the fission yeast ribosomal DNA binding factor: components share homology with Upstream Activating Factor and with SWI/SNF subunits. Nucleic Acids Res 30: 5347-5359 [Abstract] [Full Text]  
  • Guenther, M. G., Yu, J., Kao, G. D., Yen, T. J., Lazar, M. A. (2002). Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. Genes Dev. 16: 3130-3135 [Abstract] [Full Text]  
  • Demirpence, E., Semlali, A., Oliva, J., Balaguer, P., Badia, E., Duchesne, M.-J., Nicolas, J.-C., Pons, M. (2002). An Estrogen-responsive Element-targeted Histone Deacetylase Enzyme Has an Antiestrogen Activity That Differs from That of Hydroxytamoxifen. Cancer Res. 62: 6519-6528 [Abstract] [Full Text]  
  • Torres-Padilla, M. E., Sladek, F. M., Weiss, M. C. (2002). Developmentally Regulated N-terminal Variants of the Nuclear Receptor Hepatocyte Nuclear Factor 4alpha Mediate Multiple Interactions through Coactivator and Corepressor-Histone Deacetylase Complexes. J. Biol. Chem. 277: 44677-44687 [Abstract] [Full Text]  
  • Xie, A.-Y., Folk, W. R. (2002). Inhibition of Polyomavirus ori-Dependent DNA Replication by mSin3B. J. Virol. 76: 11809-11818 [Abstract] [Full Text]  
  • Lin, H.-m., Zhao, L., Cheng, S.-y. (2002). Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors. J. Biol. Chem. 277: 28733-28741 [Abstract] [Full Text]  
  • Dellaire, G., Makarov, E. M., Cowger, JeffJ.M., Longman, D., Sutherland, H. G. E., Luhrmann, R., Torchia, J., Bickmore, W. A. (2002). Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes. Mol. Cell. Biol. 22: 5141-5156 [Abstract] [Full Text]  
  • Jin, C., Li, H., Murata, T., Sun, K., Horikoshi, M., Chiu, R., Yokoyama, K. K. (2002). JDP2, a Repressor of AP-1, Recruits a Histone Deacetylase 3 Complex To Inhibit the Retinoic Acid-Induced Differentiation of F9 Cells. Mol. Cell. Biol. 22: 4815-4826 [Abstract] [Full Text]  
  • Li, J., Lin, Q., Wang, W., Wade, P., Wong, J. (2002). Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression. Genes Dev. 16: 687-692 [Abstract] [Full Text]  
  • Sterner, D. E., Wang, X., Bloom, M. H., Simon, G. M., Berger, S. L. (2002). The SANT Domain of Ada2 Is Required for Normal Acetylation of Histones by the Yeast SAGA Complex. J. Biol. Chem. 277: 8178-8186 [Abstract] [Full Text]  
  • Jepsen, K., Rosenfeld, M. G. (2002). Biological roles and mechanistic actions of co-repressor complexes. J. Cell Sci. 115: 689-698 [Abstract] [Full Text]  
  • Vaute, O., Nicolas, E., Vandel, L., Trouche, D. (2002). Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases. Nucleic Acids Res 30: 475-481 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»