Previous Article | Next Article 
Molecular and Cellular Biology, September 2001, p. 6181-6188, Vol. 21, No. 18
0270-7306/01/$04.00+0 DOI: 10.1128/MCB.21.18.6181-6188.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Acetylation of Nuclear Hormone Receptor-Interacting
Protein RIP140 Regulates Binding of the Transcriptional
Corepressor CtBP
Ngan
Vo,
Clark
Fjeld, and
Richard H.
Goodman*
Vollum Institute, Oregon Health Sciences
University, Portland, Oregon
Received 27 March 2001/Returned for modification 22 April
2001/Accepted 19 June 2001
CtBP (carboxyl-terminal binding protein) participates in regulating
cellular development and differentiation by associating with a diverse
array of transcriptional repressors. Most of these interactions occur
through a consensus CtBP-binding motif, PXDLS, in the repressor
proteins. We previously showed that the CtBP-binding motif in E1A is
flanked by a Lys residue and suggested that acetylation of this residue
by the p300/CBP-associated factor P/CAF disrupts the CtBP interaction.
In this study, we show that the interaction between CtBP and the
nuclear hormone receptor corepressor RIP140 is regulated similarly, in
this case by p300/CBP itself. CtBP was shown to interact with RIP140 in
vitro and in vivo through a sequence, PIDLSCK, in the amino-terminal
third of the RIP140 protein. Acetylation of the Lys residue in this
motif, demonstrated in vivo by using an acetylated RIP140-specific
antibody, dramatically reduced CtBP binding. Mutation of the Lys
residue to Gln resulted in a decrease in CtBP binding in vivo and a
loss of transcriptional repression. We suggest that p300/CBP-mediated
acetylation disrupts the RIP140-CtBP complex and derepresses nuclear
hormone receptor-regulated genes. Disruption of repressor-CtBP
interactions by acetylation may be a general mode of gene activation.
*
Corresponding author. Mailing address: Vollum Institute
L-474, Oregon Health Sciences University, 3181 S.W. Sam Jackson Pk. Rd., Portland, OR 97201. Phone: (503) 494-5078. Fax: (503) 494-4353. E-mail: goodmanr{at}ohsu.edu.
Molecular and Cellular Biology, September 2001, p. 6181-6188, Vol. 21, No. 18
0270-7306/01/$04.00+0 DOI: 10.1128/MCB.21.18.6181-6188.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
This article has been cited by other articles:
-
Stossi, F., Madak-Erdogan, Z., Katzenellenbogen, B. S.
(2009). Estrogen Receptor Alpha Represses Transcription of Early Target Genes via p300 and CtBP1. Mol. Cell. Biol.
29: 1749-1759
[Abstract]
[Full Text]
-
Purbey, P. K., Singh, S., Notani, D., Kumar, P. P., Limaye, A. S., Galande, S.
(2009). Acetylation-Dependent Interaction of SATB1 and CtBP1 Mediates Transcriptional Repression by SATB1. Mol. Cell. Biol.
29: 1321-1337
[Abstract]
[Full Text]
-
Zschiedrich, I., Hardeland, U., Krones-Herzig, A., Berriel Diaz, M., Vegiopoulos, A., Muggenburg, J., Sombroek, D., Hofmann, T. G., Zawatzky, R., Yu, X., Gretz, N., Christian, M., White, R., Parker, M. G., Herzig, S.
(2008). Coactivator function of RIP140 for NF{kappa}B/RelA-dependent cytokine gene expression. Blood
112: 264-276
[Abstract]
[Full Text]
-
Sue, N., Jack, B. H. A., Eaton, S. A., Pearson, R. C. M., Funnell, A. P. W., Turner, J., Czolij, R., Denyer, G., Bao, S., Molero-Navajas, J. C., Perkins, A., Fujiwara, Y., Orkin, S. H., Bell-Anderson, K., Crossley, M.
(2008). Targeted Disruption of the Basic Kruppel-Like Factor Gene (Klf3) Reveals a Role in Adipogenesis. Mol. Cell. Biol.
28: 3967-3978
[Abstract]
[Full Text]
-
Rytinki, M. M., Palvimo, J. J.
(2008). SUMOylation Modulates the Transcription Repressor Function of RIP140. J. Biol. Chem.
283: 11586-11595
[Abstract]
[Full Text]
-
Dammer, E. B., Sewer, M. B.
(2008). Phosphorylation of CtBP1 by cAMP-dependent Protein Kinase Modulates Induction of CYP17 by Stimulating Partnering of CtBP1 and 2. J. Biol. Chem.
283: 6925-6934
[Abstract]
[Full Text]
-
Herzog, B., Hallberg, M., Seth, A., Woods, A., White, R., Parker, M. G.
(2007). The Nuclear Receptor Cofactor, Receptor-Interacting Protein 140, Is Required for the Regulation of Hepatic Lipid and Glucose Metabolism by Liver X Receptor. Mol. Endocrinol.
21: 2687-2697
[Abstract]
[Full Text]
-
Bartz, R., Seemann, J., Zehmer, J. K., Serrero, G., Chapman, K. D., Anderson, R. G.W., Liu, P.
(2007). Evidence that Mono-ADP-Ribosylation of CtBP1/BARS Regulates Lipid Storage. Mol. Biol. Cell
18: 3015-3025
[Abstract]
[Full Text]
-
Heldring, N., Pike, A., Andersson, S., Matthews, J., Cheng, G., Hartman, J., Tujague, M., Strom, A., Treuter, E., Warner, M., Gustafsson, J.-A.
(2007). Estrogen Receptors: How Do They Signal and What Are Their Targets. Physiol. Rev.
87: 905-931
[Abstract]
[Full Text]
-
Stankovic-Valentin, N., Deltour, S., Seeler, J., Pinte, S., Vergoten, G., Guerardel, C., Dejean, A., Leprince, D.
(2007). An Acetylation/Deacetylation-SUMOylation Switch through a Phylogenetically Conserved {psi}KXEP Motif in the Tumor Suppressor HIC1 Regulates Transcriptional Repression Activity. Mol. Cell. Biol.
27: 2661-2675
[Abstract]
[Full Text]
-
Dammer, E. B., Leon, A., Sewer, M. B.
(2007). Coregulator Exchange and Sphingosine-Sensitive Cooperativity of Steroidogenic Factor-1, General Control Nonderepressed 5, p54, and p160 Coactivators Regulate Cyclic Adenosine 3',5'-Monophosphate-Dependent Cytochrome P450c17 Transcription Rate. Mol. Endocrinol.
21: 415-438
[Abstract]
[Full Text]
-
Lopez-Garcia, J., Periyasamy, M., Thomas, R. S., Christian, M., Leao, M., Jat, P., Kindle, K. B., Heery, D. M., Parker, M. G., Buluwela, L., Kamalati, T., Ali, S.
(2006). ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases. Nucleic Acids Res
34: 6126-6136
[Abstract]
[Full Text]
-
Germain, P., Staels, B., Dacquet, C., Spedding, M., Laudet, V.
(2006). Overview of Nomenclature of Nuclear Receptors. Pharmacol. Rev.
58: 685-704
[Abstract]
[Full Text]
-
Quinlan, K. G. R., Verger, A., Kwok, A., Lee, S. H. Y., Perdomo, J., Nardini, M., Bolognesi, M., Crossley, M.
(2006). Role of the C-Terminal Binding Protein PXDLS Motif Binding Cleft in Protein Interactions and Transcriptional Repression. Mol. Cell. Biol.
26: 8202-8213
[Abstract]
[Full Text]
-
Carascossa, S., Gobinet, J., Georget, V., Lucas, A., Badia, E., Castet, A., White, R., Nicolas, J.-C., Cavailles, V., Jalaguier, S.
(2006). Receptor-Interacting Protein 140 Is a Repressor of the Androgen Receptor Activity. Mol. Endocrinol.
20: 1506-1518
[Abstract]
[Full Text]
-
Castet, A., Herledan, A., Bonnet, S., Jalaguier, S., Vanacker, J.-M., Cavailles, V.
(2006). Receptor-Interacting Protein 140 Differentially Regulates Estrogen Receptor-Related Receptor Transactivation Depending on Target Genes. Mol. Endocrinol.
20: 1035-1047
[Abstract]
[Full Text]
-
Meloni, A. R., Lai, C.-H., Yao, T.-P., Nevins, J. R.
(2005). A Mechanism of COOH-Terminal Binding Protein-Mediated Repression. Mol Cancer Res
3: 575-583
[Abstract]
[Full Text]
-
Huq, M. D. M., Wei, L.-N.
(2005). Post-translational Modification of Nuclear Co-repressor Receptor-interacting Protein 140 by Acetylation. Mol. Cell. Proteomics
4: 975-983
[Abstract]
[Full Text]
-
Alliston, T., Ko, T. C., Cao, Y., Liang, Y.-Y., Feng, X.-H., Chang, C., Derynck, R.
(2005). Repression of Bone Morphogenetic Protein and Activin-inducible Transcription by Evi-1. J. Biol. Chem.
280: 24227-24237
[Abstract]
[Full Text]
-
Kumar, R., Gururaj, A. E., Vadlamudi, R. K., Rayala, S. K.
(2005). The Clinical Relevance of Steroid Hormone Receptor Corepressors. Clin. Cancer Res.
11: 2822-2831
[Abstract]
[Full Text]
-
Steel, J. H, White, R., Parker, M. G
(2005). Role of the RIP140 corepressor in ovulation and adipose biology. J Endocrinol
185: 1-9
[Abstract]
[Full Text]
-
White, K. A., Yore, M. M., Deng, D., Spinella, M. J.
(2005). Limiting Effects of RIP140 in Estrogen Signaling: POTENTIAL MEDIATION OF ANTI-ESTROGENIC EFFECTS OF RETINOIC ACID. J. Biol. Chem.
280: 7829-7835
[Abstract]
[Full Text]
-
Zenisek, D., Horst, N. K., Merrifield, C., Sterling, P., Matthews, G.
(2004). Visualizing Synaptic Ribbons in the Living Cell. J. Neurosci.
24: 9752-9759
[Abstract]
[Full Text]
-
Leonardsson, G., Steel, J. H., Christian, M., Pocock, V., Milligan, S., Bell, J., So, P.-W., Medina-Gomez, G., Vidal-Puig, A., White, R., Parker, M. G.
(2004). Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc. Natl. Acad. Sci. USA
101: 8437-8442
[Abstract]
[Full Text]
-
Christian, M., Tullet, J. M. A., Parker, M. G.
(2004). Characterization of Four Autonomous Repression Domains in the Corepressor Receptor Interacting Protein 140. J. Biol. Chem.
279: 15645-15651
[Abstract]
[Full Text]
-
Castet, A., Boulahtouf, A., Versini, G., Bonnet, S., Augereau, P., Vignon, F., Khochbin, S., Jalaguier, S., Cavailles, V.
(2004). Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition. Nucleic Acids Res
32: 1957-1966
[Abstract]
[Full Text]
-
Yang, X.-J.
(2004). The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res
32: 959-976
[Abstract]
[Full Text]
-
Sanyal, S., Matthews, J., Bouton, D., Kim, H.-J., Choi, H.-S., Treuter, E., Gustafsson, J.-A.
(2004). Deoxyribonucleic Acid Response Element-Dependent Regulation of Transcription by Orphan Nuclear Receptor Estrogen Receptor-Related Receptor {gamma}. Mol. Endocrinol.
18: 312-325
[Abstract]
[Full Text]
-
White, K. A., Yore, M. M., Warburton, S. L., Vaseva, A. V., Rieder, E., Freemantle, S. J., Spinella, M. J.
(2003). Negative Feedback at the Level of Nuclear Receptor Coregulation: SELF-LIMITATION OF RETINOID SIGNALING BY RIP140. J. Biol. Chem.
278: 43889-43892
[Abstract]
[Full Text]
-
De Bosscher, K., Vanden Berghe, W., Haegeman, G.
(2003). The Interplay between the Glucocorticoid Receptor and Nuclear Factor-{kappa}B or Activator Protein-1: Molecular Mechanisms for Gene Repression. Endocr. Rev.
24: 488-522
[Abstract]
[Full Text]
-
van Grunsven, L. A., Michiels, C., Van de Putte, T., Nelles, L., Wuytens, G., Verschueren, K., Huylebroeck, D.
(2003). Interaction between Smad-interacting Protein-1 and the Corepressor C-terminal Binding Protein Is Dispensable for Transcriptional Repression of E-cadherin. J. Biol. Chem.
278: 26135-26145
[Abstract]
[Full Text]
-
Tazawa, H., Osman, W., Shoji, Y., Treuter, E., Gustafsson, J.-A., Zilliacus, J.
(2003). Regulation of Subnuclear Localization Is Associated with a Mechanism for Nuclear Receptor Corepression by RIP140. Mol. Cell. Biol.
23: 4187-4198
[Abstract]
[Full Text]
-
Teyssier, C., Belguise, K., Galtier, F., Cavailles, V., Chalbos, D.
(2003). Receptor-Interacting Protein 140 Binds c-Jun and Inhibits Estradiol-Induced Activator Protein-1 Activity by Reversing Glucocorticoid Receptor-Interacting Protein 1 Effect. Mol. Endocrinol.
17: 287-299
[Abstract]
[Full Text]
-
Madison, D. L., Yaciuk, P., Kwok, R. P. S., Lundblad, J. R.
(2002). Acetylation of the Adenovirus-transforming Protein E1A Determines Nuclear Localization by Disrupting Association with Importin-alpha. J. Biol. Chem.
277: 38755-38763
[Abstract]
[Full Text]
-
Barolo, S., Stone, T., Bang, A. G., Posakony, J. W.
(2002). Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless. Genes Dev.
16: 1964-1976
[Abstract]
[Full Text]
-
Deltour, S., Pinte, S., Guerardel, C., Wasylyk, B., Leprince, D.
(2002). The Human Candidate Tumor Suppressor Gene HIC1 Recruits CtBP through a Degenerate GLDLSKK Motif. Mol. Cell. Biol.
22: 4890-4901
[Abstract]
[Full Text]
-
Leonardsson, G., Jacobs, M. A., White, R., Jeffery, R., Poulsom, R., Milligan, S., Parker, M.
(2002). Embryo Transfer Experiments and Ovarian Transplantation Identify the Ovary as the Only Site in Which Nuclear Receptor Interacting Protein 1/RIP140 Action Is Crucial for Female Fertility. Endocrinology
143: 700-707
[Abstract]
[Full Text]