This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shi, O.
Right arrow Articles by O'Brien, W. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shi, O.
Right arrow Articles by O'Brien, W. E.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, February 2001, p. 811-813, Vol. 21, No. 3
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.3.811-813.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Generation of a Mouse Model for Arginase II Deficiency by Targeted Disruption of the Arginase II Gene

Ou Shi,1 Sidney M. Morris Jr.,2 Huda Zoghbi,1,3 Carl W. Porter,4 and William E. O'Brien1,*

Department of Molecular and Human Genetics1 and Department of Pediatrics,3 Baylor College of Medicine, Houston, Texas 77030; Department of Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 152612; and Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, New York 142634

Received 6 September 2000/Accepted 8 November 2000

Mammals express two isoforms of arginase, designated types I and II. Arginase I is a component of the urea cycle, and inherited defects in arginase I have deleterious consequences in humans. In contrast, the physiologic role of arginase II has not been defined, and no deficiencies in arginase II have been identified in humans. Mice with a disruption in the arginase II gene were created to investigate the role of this enzyme. Homozygous arginase II-deficient mice were viable and apparently indistinguishable from wild-type mice, except for an elevated plasma arginine level which indicates that arginase II plays an important role in arginine homeostasis.

* Corresponding author. Mailing address: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030. Phone: (713) 798-5484. Fax: (713) 798-8937. E-mail: wobrien{at}bcm.tmc.edu.

Molecular and Cellular Biology, February 2001, p. 811-813, Vol. 21, No. 3
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.3.811-813.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Zhang, W., Baban, B., Rojas, M., Tofigh, S., Virmani, S. K., Patel, C., Behzadian, M. A., Romero, M. J., Caldwell, R. W., Caldwell, R. B. (2009). Arginase Activity Mediates Retinal Inflammation in Endotoxin-Induced Uveitis. Am. J. Pathol. 175: 891-902 [Abstract] [Full Text]  
  • Huynh, N. N., Andrews, K. L., Head, G. A., Khong, S. M.L., Mayorov, D. N., Murphy, A. J., Lambert, G., Kiriazis, H., Xu, Q., Du, X.-J., Chin-Dusting, J. P.F. (2009). Arginase II Knockout Mouse Displays a Hypertensive Phenotype Despite a Decreased Vasoconstrictory Profile. Hypertension 54: 294-301 [Abstract] [Full Text]  
  • Belik, J., Shehnaz, D., Pan, J., Grasemann, H. (2008). Developmental changes in arginase expression and activity in the lung. Am. J. Physiol. Lung Cell. Mol. Physiol. 294: L498-L504 [Abstract] [Full Text]  
  • Deignan, J. L., Livesay, J. C., Shantz, L. M., Pegg, A. E., O'Brien, W. E., Iyer, R. K., Cederbaum, S. D., Grody, W. W. (2007). Polyamine homeostasis in arginase knockout mice. Am. J. Physiol. Cell Physiol. 293: C1296-C1301 [Abstract] [Full Text]  
  • Chaturvedi, R., Asim, M., Lewis, N. D., Algood, H. M. S., Cover, T. L., Kim, P. Y., Wilson, K. T. (2007). L-Arginine Availability Regulates Inducible Nitric Oxide Synthase-Dependent Host Defense against Helicobacter pylori. Infect. Immun. 75: 4305-4315 [Abstract] [Full Text]  
  • Marathe, C., Bradley, M. N., Hong, C., Lopez, F., de Galarreta, C. M. R., Tontonoz, P., Castrillo, A. (2006). The Arginase II Gene Is an Anti-inflammatory Target of Liver X Receptor in Macrophages. J. Biol. Chem. 281: 32197-32206 [Abstract] [Full Text]  
  • Morris, S. M Jr (2006). Arginine: beyond protein. Am. J. Clin. Nutr. 83: 508S-512S [Abstract] [Full Text]  
  • White, A. R., Ryoo, S., Li, D., Champion, H. C., Steppan, J., Wang, D., Nyhan, D., Shoukas, A. A., Hare, J. M., Berkowitz, D. E. (2006). Knockdown of Arginase I Restores NO Signaling in the Vasculature of Old Rats. Hypertension 47: 245-251 [Abstract] [Full Text]  
  • Scaglia, F., Brunetti-Pierri, N., Kleppe, S., Marini, J., Carter, S., Garlick, P., Jahoor, F., O'Brien, W., Lee, B. (2004). Clinical Consequences of Urea Cycle Enzyme Deficiencies and Potential Links to Arginine and Nitric Oxide Metabolism. J. Nutr. 134: 2775S-2782S [Abstract] [Full Text]  
  • King, N. E., Rothenberg, M. E., Zimmermann, N. (2004). Arginine in Asthma and Lung Inflammation. J. Nutr. 134: 2830S-2836S [Abstract] [Full Text]  
  • Gobert, A. P., Cheng, Y., Akhtar, M., Mersey, B. D., Blumberg, D. R., Cross, R. K., Chaturvedi, R., Drachenberg, C. B., Boucher, J.-L., Hacker, A., Casero, R. A. Jr, Wilson, K. T. (2004). Protective Role of Arginase in a Mouse Model of Colitis. J. Immunol. 173: 2109-2117 [Abstract] [Full Text]  
  • Endo, M., Oyadomari, S., Terasaki, Y., Takeya, M., Suga, M., Mori, M., Gotoh, T. (2003). Induction of arginase I and II in bleomycin-induced fibrosis of mouse lung. Am. J. Physiol. Lung Cell. Mol. Physiol. 285: L313-L321 [Abstract] [Full Text]  
  • Janech, M. G., Chen, R., Klein, J., Nowak, M. W., McFee, W., Paul, R. V., Fitzgibbon, W. R., Ploth, D. W. (2002). Molecular and functional characterization of a urea transporter from the kidney of a short-finned pilot whale. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282: R1490-R1500 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»