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Molecular and Cellular Biology, March 2001, p. 1662-1671, Vol. 21, No. 5
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.5.1662-1671.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Zygotic Regulation of Maternal Cyclin A1 and B2 mRNAs

Yann Audic, Christina Anderson,dagger Robert Bhatty, and Rebecca S. Hartley*

Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa 52242

Received 30 August 2000/Returned for modification 11 October 2000/Accepted 7 December 2000

At the midblastula transition, the Xenopus laevis embryonic cell cycle is remodeled from rapid alternations between S and M phases to become the complex adult cell cycle. Cell cycle remodeling occurs after zygotic transcription initiates and is accompanied by terminal downregulation of maternal cyclins A1 and B2. We report here that the disappearance of both cyclin A1 and B2 proteins is preceded by the rapid deadenylation of their mRNAs. A specific mechanism triggers this deadenylation. This mechanism depends upon discrete regions of the 3' untranslated regions and requires zygotic transcription. Together, these results strongly suggest that zygote-dependent deadenylation of cyclin A1 and cyclin B2 mRNAs is responsible for the downregulation of these proteins. These studies also raise the possibility that zygotic control of maternal cyclins plays a role in establishing the adult cell cycle.

* Corresponding author. Mailing address: 1-572 BSB, Anatomy and Cell Biology, University of Iowa, Iowa City, IA 52242. Phone: (319) 335-7501. Fax: (319) 335-7198. E-mail: rebecca-hartley{at}uiowa.edu.

dagger Present address: Life Sciences Group, Bio-Rad Laboratories, Hercules, CA 94547.

Molecular and Cellular Biology, March 2001, p. 1662-1671, Vol. 21, No. 5
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.5.1662-1671.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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