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Molecular and Cellular Biology, April 2001, p. 2312-2323, Vol. 21, No. 7
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.7.2312-2323.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Drosophila Mediator Complex Is Broadly Utilized by Diverse Gene-Specific Transcription Factors at Different Types of Core Promoters

Jin Mo Park,1 Byung Soo Gim,1 Jung Mo Kim,1 Jeong Ho Yoon,2 Hye-Suk Kim,1 Ju-Gyeong Kang,3 and Young-Joon Kim1,*

National Creative Research Initiative Center for Genome Regulation, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440-746,1 and Digital Genomics, Inc., Seoul 120-749,2 Korea, and Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-42553

Received 26 October 2000/Returned for modification 6 December 2000/Accepted 5 January 2001

To decipher the mechanistic roles of Mediator proteins in regulating developmental specific gene expression and compare them to those of TATA-binding protein (TBP)-associated factors (TAFs), we isolated and analyzed a multiprotein complex containing Drosophila Mediator (dMediator) homologs. dMediator interacts with several sequence-specific transcription factors and basal transcription machinery and is critical for activated transcription in response to diverse transcriptional activators. The requirement for dMediator did not depend on a specific core promoter organization. By contrast, TAFs are preferentially utilized by promoters having a specific core element organization. Therefore, Mediator proteins are suggested to act as a pivotal coactivator that integrates promoter-specific activation signals to the basal transcription machinery.

* Corresponding author. Mailing address: Sungkyunkwan University School of Medicine, Chunchun-dong 300, Jangan-ku, Suwon-si, Kyunggi-do, 440-746, Korea. Phone: 82-31-299-6439. Fax: 82-31-299-6435. E-mail: yjk321{at}netian.com.

Molecular and Cellular Biology, April 2001, p. 2312-2323, Vol. 21, No. 7
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.7.2312-2323.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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