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Molecular and Cellular Biology, April 2001, p. 2496-2505, Vol. 21, No. 7
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.7.2496-2505.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Rfg1, a Protein Related to the Saccharomyces cerevisiae Hypoxic Regulator Rox1, Controls Filamentous Growth and Virulence in Candida albicans

David Kadosh and Alexander D. Johnson*

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California 94143

Received 9 October 2000/Returned for modification 30 November 2000/Accepted 18 December 2000

Candida albicans, the major fungal pathogen in humans, can undergo a reversible transition from ellipsoidal single cells (blastospores) to filaments composed of elongated cells attached end to end. This transition is thought to allow for rapid colonization of host tissues, facilitating the spread of infection. Here, we report the identification of Rfg1, a transcriptional regulator that controls filamentous growth of C. albicans in an environment-dependent manner. Rfg1 is important for virulence of C. albicans in a mouse model and is shown to control a number of genes that have been implicated in this process. The closest relative to Rfg1 in Saccharomyces cerevisiae is Rox1, a key repressor of hypoxic genes. However, Rfg1 does not appear to play a role in the regulation of hypoxic genes in C. albicans. These results demonstrate that a regulatory protein that controls the hypoxic response in S. cerevisiae controls filamentous growth and virulence in C. albicans. The observations described in this paper raise new and intriguing questions about the evolutionary relationship between these processes.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of California, San Francisco, 513 Parnassus Ave., Box 0414, San Francisco, CA 94143. Phone: (415) 476-8783. Fax: (415) 476-0939. E-mail: ajohnson{at}socrates.ucsf.edu.

Molecular and Cellular Biology, April 2001, p. 2496-2505, Vol. 21, No. 7
0270-7306/01/$04.00+0   DOI: 10.1128/MCB.21.7.2496-2505.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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