AP-1 Repressor Protein JDP-2: Inhibition of UV-Mediated Apoptosis through p53 Down-Regulation

doi:10.1128/MCB.21.9.3012-3024.2001

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Molecular and Cellular Biology, May 2001, p. 3012-3024, Vol. 21, No. 9
0270-7306/01/$04.00+0 DOI: 10.1128/MCB.21.9.3012-3024.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

AP-1 Repressor Protein JDP-2: Inhibition of UV-Mediated Apoptosis through p53 Down-Regulation

Fabrice Piu,¹^,²^,^* Ami Aronheim,¹^,³ Sigal Katz,³ and Michael Karin¹

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California at San Diego, La Jolla, California 92093-0636¹; Acadia Pharmaceuticals Inc., San Diego, California 92121²; and Department of Molecular Genetics, The B. Rappaport Faculty of Medicine, Technion, Bat Galim, Haifa 31096, Israel³

Received 12 October 2000/Returned for modification 20 November 2000/Accepted 8 February 2001

Members of the AP-1 transcription factor family, especially c-Jun and c-Fos, have long been known to mediate critical stepsin the cellular response to ultraviolet (UV) irradiation. We soughtto examine whether two newly discovered members of the AP-1 family,JDP-1 and JDP-2, also participate in the mammalian UV response.Here we report that JDP-2, but not JDP-1, is transiently inducedupon UV challenge and that elevated levels of JDP-2 increase cellsurvival following UV exposure. This protective function of JDP-2appears to be mediated through repression of p53 expression atthe transcriptional level, via a conserved atypical AP-1 sitein the p53promoter.

^* Corresponding author. Mailing address: Signal Transduction Group, Acadia Pharmaceuticals, Inc., 3911 Sorrento Valley Blvd.,San Diego, CA 92121. Phone: (858) 558-2871. Fax: (858) 558-2872.E-mail: fpiu{at}acadia-pharm.com.

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