This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by He, K.-L.
Right arrow Articles by Ting, A. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by He, K.-L.
Right arrow Articles by Ting, A. T.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, September 2002, p. 6034-6045, Vol. 22, No. 17
0270-7306/02/$04.00+0     DOI: 10.1128/MCB.22.17.6034-6045.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

A20 Inhibits Tumor Necrosis Factor (TNF) Alpha-Induced Apoptosis by Disrupting Recruitment of TRADD and RIP to the TNF Receptor 1 Complex in Jurkat T Cells

Kai-Li He and Adrian T. Ting*

Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029

Received 14 January 2002/ Returned for modification 14 February 2002/ Accepted 29 May 2002

Tumor necrosis factor receptor 1 (TNFR1) can trigger distinct signaling pathways leading to either the activation of NF-{kappa}B transcription factors or apoptosis. NF-{kappa}B activation results in the expression of antiapoptotic genes that inhibit the apoptosis pathway that is activated in parallel. However, the molecular mechanism of this inhibition remains poorly characterized. We have isolated a Jurkat T-cell mutant that exhibits enhanced sensitivity to TNF-induced apoptosis as a result of a deficiency in I-{kappa}B kinase {gamma} (IKK{gamma})/NEMO, an essential component of the IKK complex and NF-{kappa}B pathway. We show here that the zinc finger protein A20 is an NF-{kappa}B-inducible gene that can protect the IKK{gamma}-deficient cells from TNF-induced apoptosis by disrupting the recruitment of the death domain signaling molecules TRADD and RIP to the receptor signaling complex. Our study, together with reports on the role of other antiapoptotic proteins such as c-FLIP and c-IAP, suggests that, in order to ensure an effective shutdown of the apoptotic pathway, TNF induces multiple NF-{kappa}B-dependent genes that inhibit successive steps in the TNFR1 death signaling pathway.

* Corresponding author. Mailing address: Immunobiology Center, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029. Phone: (212) 659-9410. Fax: (212) 849-2525. E-mail: adrian.ting{at}mssm.edu.

Molecular and Cellular Biology, September 2002, p. 6034-6045, Vol. 22, No. 17
0022-538X/02/$04.00+0     DOI: 10.1128/MCB.22.17.6034-6045.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Misaki, T., Yamamoto, T., Suzuki, S., Fukasawa, H., Togawa, A., Ohashi, N., Suzuki, H., Fujigaki, Y., Oda, T., Uchida, C., Kitagawa, K., Hattori, T., Kitagawa, M., Hishida, A. (2009). Decrease in Tumor Necrosis Factor-{alpha} Receptor-Associated Death Domain Results from Ubiquitin-Dependent Degradation in Obstructive Renal Injury in Rats. Am. J. Pathol. 175: 74-83 [Abstract] [Full Text]  
  • Shah, M. V., Zhang, R., Irby, R., Kothapalli, R., Liu, X., Arrington, T., Frank, B., Lee, N. H., Loughran, T. P. Jr (2008). Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes. Blood 112: 770-781 [Abstract] [Full Text]  
  • Yan, G., Huang, J., Jarbadan, N. R., Jiang, Y., Cheng, H. (2008). Sequestration of NF-{kappa}B Signaling Complexes in Lipid Rafts Contributes to Repression of NF-{kappa}B in T Lymphocytes under Hyperthermia Stress. J. Biol. Chem. 283: 12489-12500 [Abstract] [Full Text]  
  • Sass, G., Shembade, N. D., Haimerl, F., Lamoureux, N., Hashemolhosseini, S., Tannapfel, A., Tiegs, G. (2007). TNF Pretreatment Interferes with Mitochondrial Apoptosis in the Mouse Liver by A20-Mediated Down-Regulation of Bax. J. Immunol. 179: 7042-7049 [Abstract] [Full Text]  
  • Hong, S., Lee, C., Kim, S.-J. (2007). Smad7 Sensitizes Tumor Necrosis Factor Induced Apoptosis through the Inhibition of Antiapoptotic Gene Expression by Suppressing Activation of the Nuclear Factor-{kappa}B Pathway. Cancer Res. 67: 9577-9583 [Abstract] [Full Text]  
  • Legarda-Addison, D., Ting, A. T. (2007). Negative Regulation of TCR Signaling by NF-{kappa}B2/p100. J. Immunol. 178: 7767-7778 [Abstract] [Full Text]  
  • Fitsialos, G., Chassot, A.-A., Turchi, L., Dayem, M. A., LeBrigand, K., Moreilhon, C., Meneguzzi, G., Busca, R., Mari, B., Barbry, P., Ponzio, G. (2007). Transcriptional Signature of Epidermal Keratinocytes Subjected to in Vitro Scratch Wounding Reveals Selective Roles for ERK1/2, p38, and Phosphatidylinositol 3-Kinase Signaling Pathways. J. Biol. Chem. 282: 15090-15102 [Abstract] [Full Text]  
  • Lobry, C., Lopez, T., Israel, A., Weil, R. (2007). Negative feedback loop in T cell activation through I{kappa}B kinase-induced phosphorylation and degradation of Bcl10. Proc. Natl. Acad. Sci. USA 104: 908-913 [Abstract] [Full Text]  
  • Loor, J. J., Dann, H. M., Guretzky, N. A. J., Everts, R. E., Oliveira, R., Green, C. A., Litherland, N. B., Rodriguez-Zas, S. L., Lewin, H. A., Drackley, J. K. (2007). Plane of nutrition prepartum alters hepatic gene expression and function in dairy cows as assessed by longitudinal transcript and metabolic profiling. Physiol. Genomics 27: 29-41 [Abstract] [Full Text]  
  • Chen, J., Carcamo, J. M., Golde, D. W. (2006). The {alpha} Subunit of the Granulocyte-Macrophage Colony-stimulating Factor Receptor Interacts with c-Kit and Inhibits c-Kit Signaling. J. Biol. Chem. 281: 22421-22426 [Abstract] [Full Text]  
  • Hai, T., Yeung, M.-L., Wood, T. G., Wei, Y., Yamaoka, S., Gatalica, Z., Jeang, K.-T., Brasier, A. R. (2006). An Alternative Splice Product of I{kappa}B Kinase (IKK{gamma}), IKK{gamma}-{Delta}, Differentially Mediates Cytokine and Human T-Cell Leukemia Virus Type 1 Tax-Induced NF-{kappa}B Activation. J. Virol. 80: 4227-4241 [Abstract] [Full Text]  
  • Zeng, H., Wu, H., Sloane, V., Jones, R., Yu, Y., Lin, P., Gewirtz, A. T., Neish, A. S. (2006). Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. Am. J. Physiol. Gastrointest. Liver Physiol. 290: G96-G108 [Abstract] [Full Text]  
  • Yang, M., Hase, H., Legarda-Addison, D., Varughese, L., Seed, B., Ting, A. T. (2005). B Cell Maturation Antigen, the Receptor for a Proliferation-Inducing Ligand and B Cell-Activating Factor of the TNF Family, Induces Antigen Presentation in B Cells. J. Immunol. 175: 2814-2824 [Abstract] [Full Text]  
  • Hezi-Yamit, A., Wong, P. W., Bien-Ly, N., Komuves, L. G., Prasad, K. S. S., Phillips, D. R., Sinha, U. (2005). Synergistic induction of tissue factor by coagulation factor Xa and TNF: Evidence for involvement of negative regulatory signaling cascades. Proc. Natl. Acad. Sci. USA 102: 12077-12082 [Abstract] [Full Text]  
  • Zhang, Y., Ting, A. T., Marcu, K. B., Bliska, J. B. (2005). Inhibition of MAPK and NF-{kappa}B Pathways Is Necessary for Rapid Apoptosis in Macrophages Infected with Yersinia. J. Immunol. 174: 7939-7949 [Abstract] [Full Text]  
  • Banno, T., Gazel, A., Blumenberg, M. (2005). Pathway-specific Profiling Identifies the NF-{kappa}B-dependent Tumor Necrosis Factor {alpha}-regulated Genes in Epidermal Keratinocytes. J. Biol. Chem. 280: 18973-18980 [Abstract] [Full Text]  
  • Tian, B., Nowak, D. E., Jamaluddin, M., Wang, S., Brasier, A. R. (2005). Identification of Direct Genomic Targets Downstream of the Nuclear Factor-{kappa}B Transcription Factor Mediating Tumor Necrosis Factor Signaling. J. Biol. Chem. 280: 17435-17448 [Abstract] [Full Text]  
  • Massa, P. E., Li, X., Hanidu, A., Siamas, J., Pariali, M., Pareja, J., Savitt, A. G., Catron, K. M., Li, J., Marcu, K. B. (2005). Gene Expression Profiling in Conjunction with Physiological Rescues of IKK{alpha}-null Cells with Wild Type or Mutant IKK{alpha} Reveals Distinct Classes of IKK{alpha}/NF-{kappa}B-dependent Genes. J. Biol. Chem. 280: 14057-14069 [Abstract] [Full Text]  
  • Takao, T., Kumagai, C., Hisakawa, N., Matsumoto, R., Hashimoto, K. (2005). Effect of 17{beta}-estradiol on tumor necrosis factor-{alpha}-induced cytotoxicity in the human peripheral T lymphocytes. J Endocrinol 184: 191-197 [Abstract] [Full Text]  
  • Gricks, C. S., Zahrieh, D., Zauls, A. J., Gorgun, G., Drandi, D., Mauerer, K., Neuberg, D., Gribben, J. G. (2004). Differential regulation of gene expression following CD40 activation of leukemic compared to healthy B cells. Blood 104: 4002-4009 [Abstract] [Full Text]  
  • Papa, S., Zazzeroni, F., Pham, C. G., Bubici, C., Franzoso, G. (2004). Linking JNK signaling to NF-{kappa}B: a key to survival. J. Cell Sci. 117: 5197-5208 [Abstract] [Full Text]  
  • Daniel, S., Arvelo, M. B., Patel, V. I., Longo, C. R., Shrikhande, G., Shukri, T., Mahiou, J., Sun, D. W., Mottley, C., Grey, S. T., Ferran, C. (2004). A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation. Blood 104: 2376-2384 [Abstract] [Full Text]  
  • Romero, D. G., Plonczynski, M., Vergara, G. R., Gomez-Sanchez, E. P., Gomez-Sanchez, C. E. (2004). Angiotensin II early regulated genes in H295R human adrenocortical cells. Physiol. Genomics 19: 106-116 [Abstract] [Full Text]  
  • Banno, T., Gazel, A., Blumenberg, M. (2004). Effects of Tumor Necrosis Factor-{alpha} (TNF{alpha}) in Epidermal Keratinocytes Revealed Using Global Transcriptional Profiling. J. Biol. Chem. 279: 32633-32642 [Abstract] [Full Text]  
  • Huang, J., Teng, L., Li, L., Liu, T., Li, L., Chen, D., Xu, L.-G., Zhai, Z., Shu, H.-B. (2004). ZNF216 Is an A20-like and I{kappa}B Kinase {gamma}-Interacting Inhibitor of NF{kappa}B Activation. J. Biol. Chem. 279: 16847-16853 [Abstract] [Full Text]  
  • Albrecht, E. A., Chinnaiyan, A. M., Varambally, S., Kumar-Sinha, C., Barrette, T. R., Sarma, J. V., Ward, P. A. (2004). C5a-Induced Gene Expression in Human Umbilical Vein Endothelial Cells. Am. J. Pathol. 164: 849-859 [Abstract] [Full Text]  
  • Zhou, H., Xiong, H., Li, H., Plevy, S. E., Walden, P. D., Sassaroli, M., Prestwich, G. D., Unkeless, J. C. (2004). Microtubule-Associated Serine/Threonine Kinase-205 kDa and Fc{gamma} Receptor Control IL-12 p40 Synthesis and NF-{kappa}B Activation. J. Immunol. 172: 2559-2568 [Abstract] [Full Text]  
  • Alarcon-Vargas, D., Ronai, Z.'e. (2004). c-Jun-NH2 Kinase (JNK) Contributes to the Regulation of c-Myc Protein Stability. J. Biol. Chem. 279: 5008-5016 [Abstract] [Full Text]  
  • Liu, H., Ma, Y., Pagliari, L. J., Perlman, H., Yu, C., Lin, A., Pope, R. M. (2004). TNF-{alpha}-Induced Apoptosis of Macrophages Following Inhibition of NF-{kappa}B: A Central Role for Disruption of Mitochondria. J. Immunol. 172: 1907-1915 [Abstract] [Full Text]  
  • Savage, K. J., Monti, S., Kutok, J. L., Cattoretti, G., Neuberg, D., de Leval, L., Kurtin, P., Cin, P. D., Ladd, C., Feuerhake, F., Aguiar, R. C. T., Li, S., Salles, G., Berger, F., Jing, W., Pinkus, G. S., Habermann, T., Dalla-Favera, R., Harris, N. L., Aster, J. C., Golub, T. R., Shipp, M. A. (2003). The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma. Blood 102: 3871-3879 [Abstract] [Full Text]  
  • Park, K.-J., Gaynor, R. B., Kwak, Y. T. (2003). Heat Shock Protein 27 Association with the I{kappa}B Kinase Complex Regulates Tumor Necrosis Factor {alpha}-induced NF-{kappa}B Activation. J. Biol. Chem. 278: 35272-35278 [Abstract] [Full Text]  
  • Malewicz, M., Zeller, N., Yilmaz, Z. B., Weih, F. (2003). NF{kappa}B Controls the Balance between Fas and Tumor Necrosis Factor Cell Death Pathways during T Cell Receptor-induced Apoptosis Via the Expression of Its Target Gene A20. J. Biol. Chem. 278: 32825-32833 [Abstract] [Full Text]  
  • Robertson, M., Liversidge, J., Forrester, J. V., Dick, A. D. (2003). Neutralizing Tumor Necrosis Factor-{alpha} Activity Suppresses Activation of Infiltrating Macrophages in Experimental Autoimmune Uveoretinitis. IOVS 44: 3034-3041 [Abstract] [Full Text]  
  • Takada, H., Chen, N.-J., Mirtsos, C., Suzuki, S., Suzuki, N., Wakeham, A., Mak, T. W., Yeh, W.-C. (2003). Role of SODD in Regulation of Tumor Necrosis Factor Responses. Mol. Cell. Biol. 23: 4026-4033 [Abstract] [Full Text]  
  • Ladner, K. J., Caligiuri, M. A., Guttridge, D. C. (2003). Tumor Necrosis Factor-regulated Biphasic Activation of NF-kappa B Is Required for Cytokine-induced Loss of Skeletal Muscle Gene Products. J. Biol. Chem. 278: 2294-2303 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»