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Molecular and Cellular Biology, September 2002, p. 6471-6479, Vol. 22, No. 18
0270-7306/02/$04.00+0     DOI: 10.1128/MCB.22.18.6471-6479.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Maximal Induction of a Subset of Interferon Target Genes Requires the Chromatin-Remodeling Activity of the BAF Complex

Hong Liu,1 Hyeog Kang,1 Rui Liu,1 Xin Chen,2 and Keji Zhao1*

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892,1 Howard Hughes Medical Institute, School of Medicine, Stanford University, Stanford, California 943052

Received 28 March 2002/ Returned for modification 9 May 2002/ Accepted 18 June 2002

The mammalian SWI/SNF-like chromatin-remodeling BAF complex plays several important roles in controlling cell proliferation and differentiation. Interferons (IFNs) are key mediators of cellular antiviral and antiproliferative activities. In this report, we demonstrate that the BAF complex is required for the maximal induction of a subset of IFN target genes by alpha IFN (IFN-{alpha}). The BAF complex is constitutively associated with the IFITM3 promoter in vivo and facilitates the chromatin remodeling of the promoter upon IFN-{alpha} induction. Furthermore, we show that the ubiquitous transcription activator Sp1 interacts with the BAF complex in vivo and augments the BAF-mediated activation of the IFITM3 promoter. Sp1 binds constitutively to the IFITM3 promoter in the absence of the BAF complex, suggesting that it may recruit and/or stabilize the BAF complex binding to the IFITM3 promoter. Our results bring new mechanistic insights into the antiproliferative effects of the chromatin-remodeling BAF complex.

* Corresponding author. Mailing address: Laboratory of Molecular Immunology, NHLBI, NIH, Building 10, Room 7N252, 9000 Rockville Pike, Bethesda, MD 20892-1674. Phone: (301) 496-2098. Fax: (301) 402-0971. E-mail: zhaok{at}nhlbi.nih.gov.

Molecular and Cellular Biology, September 2002, p. 6471-6479, Vol. 22, No. 18
0022-538X/02/$04.00+0     DOI: 10.1128/MCB.22.18.6471-6479.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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