This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shioi, T.
Right arrow Articles by Izumo, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shioi, T.
Right arrow Articles by Izumo, S.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, April 2002, p. 2799-2809, Vol. 22, No. 8
0270-7306/02/$04.00+0     DOI: 10.1128/MCB.22.8.2799-2809.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Akt/Protein Kinase B Promotes Organ Growth in Transgenic Mice

Tetsuo Shioi,1,2 Julie R. McMullen,1,2 Peter M. Kang,1,2 Pamela S. Douglas,1,2 Toshiyuki Obata,3,4 Thomas F. Franke,5 Lewis C. Cantley,3,4 and Seigo Izumo1,2*

Cardiovascular Division,1 Division of Signal Transduction, Beth Israel Deaconess Medical Center ,3 Departments of Medicine,2 Cell Biology, Harvard Medical School, Boston, Massachusetts ,4 Department of Pharmacology, Columbia University, New York, New York5

Received 10 May 2001/ Returned for modification 10 July 2001/ Accepted 15 November 2001

One of the least-understood areas in biology is the determination of the size of animals and their organs. In Drosophila, components of the insulin receptor phosphoinositide 3-kinase (PI3K) pathway determine body, organ, and cell size. Several biochemical studies have suggested that Akt/protein kinase B is one of the important downstream targets of PI3K. To examine the role of Akt in the regulation of organ size in mammals, we have generated and characterized transgenic mice expressing constitutively active Akt (caAkt) or kinase-deficient Akt (kdAkt) specifically in the heart. The heart weight of caAkt transgenic mice was increased 2.0-fold compared with that of nontransgenic mice. The increase in heart size was associated with a comparable increase in myocyte cell size in caAkt mice. The kdAkt mutant protein attenuated the constitutively active PI3K-induced overgrowth of the heart, and the caAkt mutant protein circumvented cardiac growth retardation induced by a kinase-deficient PI3K mutant protein. Rapamycin attenuated caAkt-induced overgrowth of the heart, suggesting that the mammalian target of rapamycin (mTOR) or effectors of mTOR mediated caAkt-induced heart growth. In conclusion, Akt is sufficient to induce a marked increase in heart size and is likely to be one of the effectors of the PI3K pathway in mediating heart growth.

* Corresponding author. Mailing address: Cardiovascular Division, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215. Phone: (617) 667-4858. Fax: (617) 975-5268. E-mail: sizumo{at}caregroup.harvard.edu.

Molecular and Cellular Biology, April 2002, p. 2799-2809, Vol. 22, No. 8
0022-538X/02/$04.00+0     DOI: 10.1128/MCB.22.8.2799-2809.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Catalucci, D., Latronico, M. V. G., Ceci, M., Rusconi, F., Young, H. S., Gallo, P., Santonastasi, M., Bellacosa, A., Brown, J. H., Condorelli, G. (2009). Akt Increases Sarcoplasmic Reticulum Ca2+ Cycling by Direct Phosphorylation of Phospholamban at Thr17. J. Biol. Chem. 284: 28180-28187 [Abstract] [Full Text]  
  • Altamirano, F., Oyarce, C., Silva, P., Toyos, M., Wilson, C., Lavandero, S., Uhlen, P., Estrada, M. (2009). Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway. J Endocrinol 202: 299-307 [Abstract] [Full Text]  
  • Braz, J. C., Gill, R. M., Corbly, A. K., Jones, B. D., Jin, N., Vlahos, C. J., Wu, Q., Shen, W. (2009). Selective activation of PI3K{alpha}/Akt/GSK-3{beta} signalling and cardiac compensatory hypertrophy during recovery from heart failure. Eur J Heart Fail 11: 739-748 [Abstract] [Full Text]  
  • DiMichele, L. A., Hakim, Z. S., Sayers, R. L., Rojas, M., Schwartz, R. J., Mack, C. P., Taylor, J. M. (2009). Transient Expression of FRNK Reveals Stage-Specific Requirement for Focal Adhesion Kinase Activity in Cardiac Growth. Circ. Res. 104: 1201-1208 [Abstract] [Full Text]  
  • Oudit, G. Y., Penninger, J. M. (2009). Cardiac regulation by phosphoinositide 3-kinases and PTEN. Cardiovasc Res 82: 250-260 [Abstract] [Full Text]  
  • Miyamoto, S., Rubio, M., Sussman, M. A. (2009). Nuclear and mitochondrial signalling Akts in cardiomyocytes. Cardiovasc Res 82: 272-285 [Abstract] [Full Text]  
  • Liu, W., Zi, M., Jin, J., Prehar, S., Oceandy, D., Kimura, T. E., Lei, M., Neyses, L., Weston, A. H., Cartwright, E. J., Wang, X. (2009). Cardiac-Specific Deletion of Mkk4 Reveals Its Role in Pathological Hypertrophic Remodeling but Not in Physiological Cardiac Growth. Circ. Res. 104: 905-914 [Abstract] [Full Text]  
  • Darmellah, A., Rucker-Martin, C., Feuvray, D. (2009). ERM proteins mediate the effects of Na+/H+ exchanger (NHE1) activation in cardiac myocytes. Cardiovasc Res 81: 294-300 [Abstract] [Full Text]  
  • Teos, L. Y., Zhao, A., Alvin, Z., Laurence, G. G., Li, C., Haddad, G. E. (2008). Basal and IGF-I-dependent regulation of potassium channels by MAP kinases and PI3-kinase during eccentric cardiac hypertrophy. Am. J. Physiol. Heart Circ. Physiol. 295: H1834-H1845 [Abstract] [Full Text]  
  • Marin, T. M., Clemente, C. F.M.Z., Santos, A. M., Picardi, P. K., Pascoal, V. D.B., Lopes-Cendes, I., Saad, M. J.A., Franchini, K. G. (2008). Shp2 Negatively Regulates Growth in Cardiomyocytes by Controlling Focal Adhesion Kinase/Src and mTOR Pathways. Circ. Res. 103: 813-824 [Abstract] [Full Text]  
  • Zdychova, J., Kazdova, L., Pelikanova, T., Lindsley, J. N., Anderson, S., Komers, R. (2008). Renal Activity of Akt Kinase in Obese Zucker Rats. Exp. Biol. Med. 233: 1231-1241 [Abstract] [Full Text]  
  • Yano, N., Tseng, A., Zhao, T. C., Robbins, J., Padbury, J. F., Tseng, Y.-T. (2008). Temporally controlled overexpression of cardiac-specific PI3K{alpha} induces enhanced myocardial contractility--a new transgenic model. Am. J. Physiol. Heart Circ. Physiol. 295: H1690-H1694 [Abstract] [Full Text]  
  • Papparella, I., Ceolotto, G., Montemurro, D., Antonello, M., Garbisa, S., Rossi, G., Semplicini, A. (2008). Green Tea Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Rats by Modulating Reactive Oxygen Species Production and the Src/Epidermal Growth Factor Receptor/Akt Signaling Pathway. J. Nutr. 138: 1596-1601 [Abstract] [Full Text]  
  • Fang, C. X., Dong, F., Thomas, D. P., Ma, H., He, L., Ren, J. (2008). Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription. Am. J. Physiol. Heart Circ. Physiol. 295: H1206-H1215 [Abstract] [Full Text]  
  • Chan, A. Y. M., Dolinsky, V. W., Soltys, C.-L. M., Viollet, B., Baksh, S., Light, P. E., Dyck, J. R. B. (2008). Resveratrol Inhibits Cardiac Hypertrophy via AMP-activated Protein Kinase and Akt. J. Biol. Chem. 283: 24194-24201 [Abstract] [Full Text]  
  • Bertrand, L., Horman, S., Beauloye, C., Vanoverschelde, J.-L. (2008). Insulin signalling in the heart. Cardiovasc Res 79: 238-248 [Abstract] [Full Text]  
  • Flores, A. I., Narayanan, S. P., Morse, E. N., Shick, H. E., Yin, X., Kidd, G., Avila, R. L., Kirschner, D. A., Macklin, W. B. (2008). Constitutively Active Akt Induces Enhanced Myelination in the CNS. J. Neurosci. 28: 7174-7183 [Abstract] [Full Text]  
  • Ha, T., Hua, F., Liu, X., Ma, J., McMullen, J. R., Shioi, T., Izumo, S., Kelley, J., Gao, X., Browder, W., Williams, D. L., Kao, R. L., Li, C. (2008). Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism. Cardiovasc Res 78: 546-553 [Abstract] [Full Text]  
  • Shen, W.-H., Chen, Z., Shi, S., Chen, H., Zhu, W., Penner, A., Bu, G., Li, W., Boyle, D. W., Rubart, M., Field, L. J., Abraham, R., Liechty, E. A., Shou, W. (2008). Cardiac Restricted Overexpression of Kinase-dead Mammalian Target of Rapamycin (mTOR) Mutant Impairs the mTOR-mediated Signaling and Cardiac Function. J. Biol. Chem. 283: 13842-13849 [Abstract] [Full Text]  
  • Jacobshagen, C., Gruber, M., Teucher, N., Schmidt, A. G., Unsold, B. W., Toischer, K., Nguyen Van, P., Maier, L. S., Kogler, H., Hasenfuss, G. (2008). Celecoxib modulates hypertrophic signalling and prevents load-induced cardiac dysfunction. Eur J Heart Fail 10: 334-342 [Abstract] [Full Text]  
  • Morisco, C., Marrone, C., Galeotti, J., Shao, D., Vatner, D. E., Vatner, S. F., Sadoshima, J. (2008). Endocytosis machinery is required for {beta}1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes. Cardiovasc Res 78: 36-44 [Abstract] [Full Text]  
  • Murtaza, I., Wang, H.-X., Feng, X., Alenina, N., Bader, M., Prabhakar, B. S., Li, P.-F. (2008). Down-regulation of Catalase and Oxidative Modification of Protein Kinase CK2 Lead to the Failure of Apoptosis Repressor with Caspase Recruitment Domain to Inhibit Cardiomyocyte Hypertrophy. J. Biol. Chem. 283: 5996-6004 [Abstract] [Full Text]  
  • Bera, T. K., Liu, X.-F., Yamada, M., Gavrilova, O., Mezey, E., Tessarollo, L., Anver, M., Hahn, Y., Lee, B., Pastan, I. (2008). A model for obesity and gigantism due to disruption of the Ankrd26 gene. Proc. Natl. Acad. Sci. USA 105: 270-275 [Abstract] [Full Text]  
  • Liao, R., Force, T. (2007). Not All Hypertrophy Is Created Equal. Circ. Res. 101: 1069-1072 [Full Text]  
  • Segrelles, C., Lu, J., Hammann, B., Santos, M., Moral, M., Cascallana, J. L., Lara, M. F., Rho, O., Carbajal, S., Traag, J., Beltran, L., Martinez-Cruz, A. B., Garcia-Escudero, R., Lorz, C., Ruiz, S., Bravo, A., Paramio, J. M., DiGiovanni, J. (2007). Deregulated Activity of Akt in Epithelial Basal Cells Induces Spontaneous Tumors and Heightened Sensitivity to Skin Carcinogenesis. Cancer Res. 67: 10879-10888 [Abstract] [Full Text]  
  • Okumura, S., Vatner, D. E., Kurotani, R., Bai, Y., Gao, S., Yuan, Z., Iwatsubo, K., Ulucan, C., Kawabe, J.-i., Ghosh, K., Vatner, S. F., Ishikawa, Y. (2007). Disruption of Type 5 Adenylyl Cyclase Enhances Desensitization of Cyclic Adenosine Monophosphate Signal and Increases Akt Signal With Chronic Catecholamine Stress. Circulation 116: 1776-1783 [Abstract] [Full Text]  
  • Sharma, S., Guthrie, P. H., Chan, S. S., Haq, S., Taegtmeyer, H. (2007). Glucose phosphorylation is required for insulin-dependent mTOR signalling in the heart. Cardiovasc Res 76: 71-80 [Abstract] [Full Text]  
  • Mullany, L. K., Nelsen, C. J., Hanse, E. A., Goggin, M. M., Anttila, C. K., Peterson, M., Bitterman, P. B., Raghavan, A., Crary, G. S., Albrecht, J. H. (2007). Akt-mediated Liver Growth Promotes Induction of Cyclin E through a Novel Translational Mechanism and a p21-mediated Cell Cycle Arrest. J. Biol. Chem. 282: 21244-21252 [Abstract] [Full Text]  
  • Hannigan, G. E., Coles, J. G., Dedhar, S. (2007). Integrin-Linked Kinase at the Heart of Cardiac Contractility, Repair, and Disease. Circ. Res. 100: 1408-1414 [Abstract] [Full Text]  
  • Dorn, G. W. II (2007). The Fuzzy Logic of Physiological Cardiac Hypertrophy. Hypertension 49: 962-970 [Full Text]  
  • Ahuja, P., Sdek, P., MacLellan, W. R. (2007). Cardiac Myocyte Cell Cycle Control in Development, Disease, and Regeneration. Physiol. Rev. 87: 521-544 [Abstract] [Full Text]  
  • Laustsen, P. G., Russell, S. J., Cui, L., Entingh-Pearsall, A., Holzenberger, M., Liao, R., Kahn, C. R. (2007). Essential Role of Insulin and Insulin-Like Growth Factor 1 Receptor Signaling in Cardiac Development and Function. Mol. Cell. Biol. 27: 1649-1664 [Abstract] [Full Text]  
  • Sharma, N., Okere, I. C., Duda, M. K., Chess, D. J., O'Shea, K. M., Stanley, W. C. (2007). Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy. Cardiovasc Res 73: 257-268 [Abstract] [Full Text]  
  • McMullen, J. R., Amirahmadi, F., Woodcock, E. A., Schinke-Braun, M., Bouwman, R. D., Hewitt, K. A., Mollica, J. P., Zhang, L., Zhang, Y., Shioi, T., Buerger, A., Izumo, S., Jay, P. Y., Jennings, G. L. (2007). Protective effects of exercise and phosphoinositide 3-kinase(p110{alpha}) signaling in dilated and hypertrophic cardiomyopathy. Proc. Natl. Acad. Sci. USA 104: 612-617 [Abstract] [Full Text]  
  • Shiojima, I., Walsh, K. (2006). Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway. Genes Dev. 20: 3347-3365 [Abstract] [Full Text]  
  • Ries, V., Henchcliffe, C., Kareva, T., Rzhetskaya, M., Bland, R., During, M. J., Kholodilov, N., Burke, R. E. (2006). Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease. Proc. Natl. Acad. Sci. USA 103: 18757-18762 [Abstract] [Full Text]  
  • Limesand, K. H., Schwertfeger, K. L., Anderson, S. M. (2006). MDM2 Is Required for Suppression of Apoptosis by Activated Akt1 in Salivary Acinar Cells. Mol. Cell. Biol. 26: 8840-8856 [Abstract] [Full Text]  
  • Dummler, B., Tschopp, O., Hynx, D., Yang, Z.-Z., Dirnhofer, S., Hemmings, B. A. (2006). Life with a Single Isoform of Akt: Mice Lacking Akt2 and Akt3 Are Viable but Display Impaired Glucose Homeostasis and Growth Deficiencies. Mol. Cell. Biol. 26: 8042-8051 [Abstract] [Full Text]  
  • Merten, K. E., Jiang, Y., Feng, W., Kang, Y. J. (2006). Calcineurin Activation Is Not Necessary for Doxorubicin-Induced Hypertrophy in H9c2 Embryonic Rat Cardiac Cells: Involvement of the Phosphoinositide 3-Kinase-Akt Pathway. J. Pharmacol. Exp. Ther. 319: 934-940 [Abstract] [Full Text]  
  • DeBosch, B., Sambandam, N., Weinheimer, C., Courtois, M., Muslin, A. J. (2006). Akt2 Regulates Cardiac Metabolism and Cardiomyocyte Survival. J. Biol. Chem. 281: 32841-32851 [Abstract] [Full Text]  
  • Schiekofer, S., Shiojima, I., Sato, K., Galasso, G., Oshima, Y., Walsh, K. (2006). Microarray analysis of Akt1 activation in transgenic mouse hearts reveals transcript expression profiles associated with compensatory hypertrophy and failure. Physiol. Genomics 27: 156-170 [Abstract] [Full Text]  
  • Chen, H., Yong, W., Ren, S., Shen, W., He, Y., Cox, K. A., Zhu, W., Li, W., Soonpaa, M., Payne, R. M., Franco, D., Field, L. J., Rosen, V., Wang, Y., Shou, W. (2006). Overexpression of Bone Morphogenetic Protein 10 in Myocardium Disrupts Cardiac Postnatal Hypertrophic Growth. J. Biol. Chem. 281: 27481-27491 [Abstract] [Full Text]  
  • Hingtgen, S. D., Tian, X., Yang, J., Dunlay, S. M., Peek, A. S., Wu, Y., Sharma, R. V., Engelhardt, J. F., Davisson, R. L. (2006). Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy. Physiol. Genomics 26: 180-191 [Abstract] [Full Text]  
  • Catalucci, D., Condorelli, G. (2006). Effects of Akt on Cardiac Myocytes: Location Counts. Circ. Res. 99: 339-341 [Full Text]  
  • Gude, N., Muraski, J., Rubio, M., Kajstura, J., Schaefer, E., Anversa, P., Sussman, M. A. (2006). Akt Promotes Increased Cardiomyocyte Cycling and Expansion of the Cardiac Progenitor Cell Population. Circ. Res. 99: 381-388 [Abstract] [Full Text]  
  • Han, Y., Chen, Y.-S., Liu, Z., Bodyak, N., Rigor, D., Bisping, E., Pu, W. T., Kang, P. M. (2006). Overexpression of HAX-1 Protects Cardiac Myocytes From Apoptosis Through Caspase-9 Inhibition. Circ. Res. 99: 415-423 [Abstract] [Full Text]  
  • Tsujita, Y., Muraski, J., Shiraishi, I., Kato, T., Kajstura, J., Anversa, P., Sussman, M. A. (2006). Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophy. Proc. Natl. Acad. Sci. USA 103: 11946-11951 [Abstract] [Full Text]  
  • Kenessey, A., Ojamaa, K. (2006). Thyroid Hormone Stimulates Protein Synthesis in the Cardiomyocyte by Activating the Akt-mTOR and p70S6K Pathways. J. Biol. Chem. 281: 20666-20672 [Abstract] [Full Text]  
  • Herranz, H., Morata, G., Milan, M. (2006). calderon encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues. Development 133: 2617-2625 [Abstract] [Full Text]  
  • Mahimainathan, L., Das, F., Venkatesan, B., Choudhury, G. G. (2006). Mesangial Cell Hypertrophy by High Glucose Is Mediated by Downregulation of the Tumor Suppressor PTEN.. Diabetes 55: 2115-2125 [Abstract] [Full Text]  
  • Dyck, J. R. B., Lopaschuk, G. D. (2006). AMPK alterations in cardiac physiology and pathology: enemy or ally?. J. Physiol. 574: 95-112 [Abstract] [Full Text]  
  • Kulandavelu, S., Qu, D., Adamson, S. L. (2006). Cardiovascular Function in Mice During Normal Pregnancy and in the Absence of Endothelial NO Synthase. Hypertension 47: 1175-1182 [Abstract] [Full Text]  
  • Walsh, K. (2006). Akt Signaling and Growth of the Heart. Circulation 113: 2032-2034 [Full Text]  
  • DeBosch, B., Treskov, I., Lupu, T. S., Weinheimer, C., Kovacs, A., Courtois, M., Muslin, A. J. (2006). Akt1 Is Required for Physiological Cardiac Growth. Circulation 113: 2097-2104 [Abstract] [Full Text]  
  • Barry, J. S., Davidsen, M. L., Limesand, S. W., Galan, H. L., Friedman, J. E., Regnault, T. R. H., Hay, W. W. Jr. (2006). Developmental Changes in Ovine Myocardial Glucose Transporters and Insulin Signaling Following Hyperthermia-Induced Intrauterine Fetal Growth Restriction.. Exp. Biol. Med. 231: 566-575 [Abstract] [Full Text]  
  • Matsui, T., Nagoshi, T., Hong, E.-G., Luptak, I., Hartil, K., Li, L., Gorovits, N., Charron, M. J., Kim, J. K., Tian, R., Rosenzweig, A. (2006). Effects of chronic Akt activation on glucose uptake in the heart. Am. J. Physiol. Endocrinol. Metab. 290: E789-E797 [Abstract] [Full Text]  
  • McNally, E. M. (2006). Hypertrophic Cardiomyopathy: Exercise and Eat Right. Circ. Res. 98: 443-445 [Full Text]  
  • Higuchi, Y., Chan, T. O., Brown, M. A., Zhang, J., DeGeorge, B. R. Jr., Funakoshi, H., Gibson, G., McTiernan, C. F., Kubota, T., Jones, W. K., Feldman, A. M. (2006). Cardioprotection afforded by NF-{kappa}B ablation is associated with activation of Akt in mice overexpressing TNF-{alpha}. Am. J. Physiol. Heart Circ. Physiol. 290: H590-H598 [Abstract] [Full Text]  
  • Kang, Y. J. (2006). Cardiac Hypertrophy: A Risk Factor for QT-Prolongation and Cardiac Sudden Death. Toxicol Pathol 34: 58-66 [Abstract] [Full Text]  
  • Rota, M., Boni, A., Urbanek, K., Padin-Iruegas, M. E., Kajstura, T. J., Fiore, G., Kubo, H., Sonnenblick, E. H., Musso, E., Houser, S. R., Leri, A., Sussman, M. A., Anversa, P. (2005). Nuclear Targeting of Akt Enhances Ventricular Function and Myocyte Contractility. Circ. Res. 97: 1332-1341 [Abstract] [Full Text]  
  • Wohlschlaeger, J., Schmitz, K. J., Schmid, C., Schmid, K. W., Keul, P., Takeda, A., Weis, S., Levkau, B., Baba, H. A. (2005). Reverse remodeling following insertion of left ventricular assist devices (LVAD): A review of the morphological and molecular changes. Cardiovasc Res 68: 376-386 [Abstract] [Full Text]  
  • Luo, J., McMullen, J. R., Sobkiw, C. L., Zhang, L., Dorfman, A. L., Sherwood, M. C., Logsdon, M. N., Horner, J. W., DePinho, R. A., Izumo, S., Cantley, L. C. (2005). Class IA Phosphoinositide 3-Kinase Regulates Heart Size and Physiological Cardiac Hypertrophy. Mol. Cell. Biol. 25: 9491-9502 [Abstract] [Full Text]  
  • Hedhli, N., Pelat, M., Depre, C. (2005). Protein turnover in cardiac cell growth and survival. Cardiovasc Res 68: 186-196 [Abstract] [Full Text]  
  • Ha, T., Li, Y., Hua, F., Ma, J., Gao, X., Kelley, J., Zhao, A., Haddad, G. E., Williams, D. L., William Browder, I., Kao, R. L., Li, C. (2005). Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload. Cardiovasc Res 68: 224-234 [Abstract] [Full Text]  
  • Varma, S., Lal, B. K., Zheng, R., Breslin, J. W., Saito, S., Pappas, P. J., Hobson, R. W. II, Duran, W. N. (2005). Hyperglycemia alters PI3k and Akt signaling and leads to endothelial cell proliferative dysfunction. Am. J. Physiol. Heart Circ. Physiol. 289: H1744-H1751 [Abstract] [Full Text]  
  • Tschopp, O., Yang, Z.-Z., Brodbeck, D., Dummler, B. A., Hemmings-Mieszczak, M., Watanabe, T., Michaelis, T., Frahm, J., Hemmings, B. A. (2005). Essential role of protein kinase B{gamma} (PKB{gamma}/Akt3) in postnatal brain development but not in glucose homeostasis. Development 132: 2943-2954 [Abstract] [Full Text]  
  • Skurk, C., Izumiya, Y., Maatz, H., Razeghi, P., Shiojima, I., Sandri, M., Sato, K., Zeng, L., Schiekofer, S., Pimentel, D., Lecker, S., Taegtmeyer, H., Goldberg, A. L., Walsh, K. (2005). The FOXO3a Transcription Factor Regulates Cardiac Myocyte Size Downstream of AKT Signaling. J. Biol. Chem. 280: 20814-20823 [Abstract] [Full Text]  
  • Aoyama, T., Matsui, T., Novikov, M., Park, J., Hemmings, B., Rosenzweig, A. (2005). Serum and Glucocorticoid-Responsive Kinase-1 Regulates Cardiomyocyte Survival and Hypertrophic Response. Circulation 111: 1652-1659 [Abstract] [Full Text]  
  • Easton, R. M., Cho, H., Roovers, K., Shineman, D. W., Mizrahi, M., Forman, M. S., Lee, V. M.-Y., Szabolcs, M., de Jong, R., Oltersdorf, T., Ludwig, T., Efstratiadis, A., Birnbaum, M. J. (2005). Role for Akt3/Protein Kinase B{gamma} in Attainment of Normal Brain Size. Mol. Cell. Biol. 25: 1869-1878 [Abstract] [Full Text]  
  • Song, H. H., Shi, W., Xiang, Y.-Y., Filmus, J. (2005). The Loss of Glypican-3 Induces Alterations in Wnt Signaling. J. Biol. Chem. 280: 2116-2125 [Abstract] [Full Text]  
  • Kathiriya, I. S., King, I. N., Murakami, M., Nakagawa, M., Astle, J. M., Gardner, K. A., Gerard, R. D., Olson, E. N., Srivastava, D., Nakagawa, O. (2004). Hairy-related Transcription Factors Inhibit GATA-dependent Cardiac Gene Expression through a Signal-responsive Mechanism. J. Biol. Chem. 279: 54937-54943 [Abstract] [Full Text]  
  • Lai, K.-M. V., Gonzalez, M., Poueymirou, W. T., Kline, W. O., Na, E., Zlotchenko, E., Stitt, T. N., Economides, A. N., Yancopoulos, G. D., Glass, D. J. (2004). Conditional Activation of Akt in Adult Skeletal Muscle Induces Rapid Hypertrophy. Mol. Cell. Biol. 24: 9295-9304 [Abstract] [Full Text]  
  • Li, Y., Ha, T., Gao, X., Kelley, J., Williams, D. L., Browder, I. W., Kao, R. L., Li, C. (2004). NF-{kappa}B activation is required for the development of cardiac hypertrophy in vivo. Am. J. Physiol. Heart Circ. Physiol. 287: H1712-H1720 [Abstract] [Full Text]  
  • Hafizi, S., Wang, X., Chester, A. H., Yacoub, M. H., Proud, C. G. (2004). ANG II activates effectors of mTOR via PI3-K signaling in human coronary smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 287: H1232-H1238 [Abstract] [Full Text]  
  • Proud, C. G (2004). Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy. Cardiovasc Res 63: 403-413 [Abstract] [Full Text]  
  • Chan, A. Y. M., Soltys, C.-L. M., Young, M. E., Proud, C. G., Dyck, J. R. B. (2004). Activation of AMP-activated Protein Kinase Inhibits Protein Synthesis Associated with Hypertrophy in the Cardiac Myocyte. J. Biol. Chem. 279: 32771-32779 [Abstract] [Full Text]  
  • Harrington, L. S., Findlay, G. M., Gray, A., Tolkacheva, T., Wigfield, S., Rebholz, H., Barnett, J., Leslie, N. R., Cheng, S., Shepherd, P. R., Gout, I., Downes, C. P., Lamb, R. F. (2004). The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. JCB 166: 213-223 [Abstract] [Full Text]  
  • McMullen, J. R., Shioi, T., Zhang, L., Tarnavski, O., Sherwood, M. C., Dorfman, A. L., Longnus, S., Pende, M., Martin, K. A., Blenis, J., Thomas, G., Izumo, S. (2004). Deletion of Ribosomal S6 Kinases Does Not Attenuate Pathological, Physiological, or Insulin-Like Growth Factor 1 Receptor-Phosphoinositide 3-Kinase-Induced Cardiac Hypertrophy. Mol. Cell. Biol. 24: 6231-6240 [Abstract] [Full Text]  
  • Goren, H. J., Kulkarni, R. N., Kahn, C. R. (2004). Glucose Homeostasis and Tissue Transcript Content of Insulin Signaling Intermediates in Four Inbred Strains of Mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1. Endocrinology 145: 3307-3323 [Abstract] [Full Text]  
  • Ono, K., Iwanaga, Y., Hirayama, M., Kawamura, T., Sowa, N., Hasegawa, K. (2004). Contribution of caveolin-1{alpha} and Akt to TNF-{alpha}-induced cell death. Am. J. Physiol. Lung Cell. Mol. Physiol. 287: L201-L209 [Abstract] [Full Text]  
  • McMullen, J. R., Sherwood, M. C., Tarnavski, O., Zhang, L., Dorfman, A. L., Shioi, T., Izumo, S. (2004). Inhibition of mTOR Signaling With Rapamycin Regresses Established Cardiac Hypertrophy Induced by Pressure Overload. Circulation 109: 3050-3055 [Abstract] [Full Text]  
  • Michael, A., Haq, S., Chen, X., Hsich, E., Cui, L., Walters, B., Shao, Z., Bhattacharya, K., Kilter, H., Huggins, G., Andreucci, M., Periasamy, M., Solomon, R. N., Liao, R., Patten, R., Molkentin, J. D., Force, T. (2004). Glycogen Synthase Kinase-3{beta} Regulates Growth, Calcium Homeostasis, and Diastolic Function in the Heart. J. Biol. Chem. 279: 21383-21393 [Abstract] [Full Text]  
  • Shiraishi, I., Melendez, J., Ahn, Y., Skavdahl, M., Murphy, E., Welch, S., Schaefer, E., Walsh, K., Rosenzweig, A., Torella, D., Nurzynska, D., Kajstura, J., Leri, A., Anversa, P., Sussman, M. A. (2004). Nuclear Targeting of Akt Enhances Kinase Activity and Survival of Cardiomyocytes. Circ. Res. 94: 884-891 [Abstract] [Full Text]  
  • Wang, G.-L., Iakova, P., Wilde, M., Awad, S., Timchenko, N. A. (2004). Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP{alpha} growth inhibitory activity. Genes Dev. 18: 912-925 [Abstract] [Full Text]  
  • Frey, N., Katus, H. A., Olson, E. N., Hill, J. A. (2004). Hypertrophy of the Heart: A New Therapeutic Target?. Circulation 109: 1580-1589 [Abstract] [Full Text]  
  • Yue, Y., Lypowy, J., Hedhli, N., Abdellatif, M. (2004). Ras GTPase-activating Protein Binds to Akt and Is Required for Its Activation. J. Biol. Chem. 279: 12883-12889 [Abstract] [Full Text]  
  • Colomer, J. M., Terasawa, M., Means, A. R. (2004). Targeted Expression of Calmodulin Increases Ventricular Cardiomyocyte Proliferation and Deoxyribonucleic Acid Synthesis during Mouse Development. Endocrinology 145: 1356-1366 [Abstract] [Full Text]  
  • Hoehn, K. L., Hudachek, S. F., Summers, S. A., Florant, G. L. (2004). Seasonal, tissue-specific regulation of Akt/protein kinase B and glycogen synthase in hibernators. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286: R498-R504 [Abstract] [Full Text]  
  • McMullen, J. R., Shioi, T., Huang, W.-Y., Zhang, L., Tarnavski, O., Bisping, E., Schinke, M., Kong, S., Sherwood, M. C., Brown, J., Riggi, L., Kang, P. M., Izumo, S. (2004). The Insulin-like Growth Factor 1 Receptor Induces Physiological Heart Growth via the Phosphoinositide 3-Kinase(p110{alpha}) Pathway. J. Biol. Chem. 279: 4782-4793 [Abstract] [Full Text]  
  • McDowell, S. A., McCall, E., Matter, W. F., Estridge, T. B., Vlahos, C. J. (2004). Phosphoinositide 3-kinase regulates excitation-contraction coupling in neonatal cardiomyocytes. Am. J. Physiol. Heart Circ. Physiol. 286: H796-H805 [Abstract] [Full Text]  
  • Wilkins, B. J., Dai, Y.-S., Bueno, O. F., Parsons, S. A., Xu, J., Plank, D. M., Jones, F., Kimball, T. R., Molkentin, J. D. (2004). Calcineurin/NFAT Coupling Participates in Pathological, but not Physiological, Cardiac Hypertrophy. Circ. Res. 94: 110-118 [Abstract] [Full Text]  
  • Kulkarni, P. A., Sano, M., Schneider, M. D. (2004). Phosphorylation of RNA Polymerase II in Cardiac Hypertrophy: Cell Enlargement Signals Converge on Cyclin T/Cdk9. Recent Prog Horm Res 59: 125-139 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»