This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Thakur, S.
Right arrow Articles by Croce, C. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thakur, S.
Right arrow Articles by Croce, C. M.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, June 2003, p. 3774-3787, Vol. 23, No. 11
0270-7306/03/$08.00+0     DOI: 10.1128/MCB.23.11.3774-3787.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Regulation of BRCA1 Transcription by Specific Single-Stranded DNA Binding Factors

Sanjay Thakur,1 Tatsuya Nakamura,1 George Calin,1 Andrea Russo,1 Joseph F. Tamburrino,1 Masayoshi Shimizu,1 Gustavo Baldassarre,1 Sabrina Battista,1 Alfredo Fusco,2 Richard P. Wassell,1 Garret Dubois,1 Hansjuerg Alder,1 and Carlo M. Croce1*

Kimmel Cancer Center, Philadelphia, Pennsylvania 19107,1 Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, 80131 Naples, Italy2

Received 26 November 2002/ Returned for modification 13 February 2003/ Accepted 6 March 2003

Since the majority of high-grade breast cancers express reduced levels of BRCA1 mRNA, we investigated the factors regulating BRCA1 transcription. Factors with specific affinity for the previously identified positive regulatory region (PRR) in the BRCA1 promoter were purified from whole-cell extracts. Identified proteins included replication protein A and a series of related factors with affinity for the sense strand of PRR. A subset of the identified factors activated the BRCA1 promoter. Identification of these families of proteins regulating the BRCA1 promoter represents an important step in the comprehension of the mechanisms responsible for breast cancer development.

* Corresponding author. Mailing address: Kimmel Cancer Center, 233 S. 10th St., 1030, BLSB, Philadelphia, PA 19107. Phone: (215) 503-4645. Fax: (215) 923-4498. E-mail: C_Croce{at}lac.jci.tju.edu.

Molecular and Cellular Biology, June 2003, p. 3774-3787, Vol. 23, No. 11
0022-538X/03/$08.00+0     DOI: 10.1128/MCB.23.11.3774-3787.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Choi, H. S., Song, K. Y., Hwang, C. K., Kim, C. S., Law, P.-Y., Wei, L.-N., Loh, H. H. (2008). A Proteomics Approach for Identification of Single Strand DNA-binding Proteins Involved in Transcriptional Regulation of Mouse {micro} Opioid Receptor Gene. Mol. Cell. Proteomics 7: 1517-1529 [Abstract] [Full Text]  
  • Choi, H. S., Kim, C. S., Hwang, C. K., Song, K. Y., Law, P.-Y., Wei, L.-N., Loh, H. H. (2007). Novel function of the poly(C)-binding protein {alpha}CP3 as a transcriptional repressor of the mu opioid receptor gene. FASEB J. 21: 3963-3973 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»