This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nakamichi, Y.
Right arrow Articles by Kato, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nakamichi, Y.
Right arrow Articles by Kato, S.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, January 2003, p. 636-644, Vol. 23, No. 2
0270-7306/03/$08.00+0     DOI: 10.1128/MCB.23.2.636-644.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Chondromodulin I Is a Bone Remodeling Factor

Yuko Nakamichi,1,2 Chisa Shukunami,3 Takashi Yamada,1,4 Ken-ichi Aihara,1 Hirotaka Kawano,4 Takashi Sato,1,5 Yuriko Nishizaki,3 Yoko Yamamoto,1 Masayo Shindo,1 Kimihiro Yoshimura,1 Takashi Nakamura,1 Naoyuki Takahashi,2 Hiroshi Kawaguchi,4 Yuji Hiraki,3 and Shigeaki Kato1,5*

The Institute of Molecular and Cellular Biosciences,1 The Department of Orthopedic Surgery, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo,4 The Institute for Oral Science, Matsumoto Dental University, Hiro-oka, Shiojiri, Nagano,2 The Institute for Frontier Medical Sciences, Kyoto University, Sakyo-ku, Kyoto,3 CREST, Japan Science and Technology, Kawaguchi, Saitama, Japan5

Received 10 May 2002/ Returned for modification 11 July 2002/ Accepted 21 October 2002

Chondromodulin I (ChM-I) was supposed from its limited expression in cartilage and its functions in cultured chondrocytes as a major regulator in cartilage development. Here, we generated mice deficient in ChM-I by targeted disruption of the ChM-I gene. No overt abnormality was detected in endochondral bone formation during embryogenesis and cartilage development during growth stages of ChM-I-/- mice. However, a significant increase in bone mineral density with lowered bone resorption with respect to formation was unexpectedly found in adult ChM-I-/- mice. Thus, the present study established that ChM-I is a bone remodeling factor.

* Corresponding author. Mailing address: The Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Phone: 81-3-5841-8478. Fax: 81-3-5841-8477. E-mail: uskato{at}mail.ecc.u-tokyo.ac.jp.

Molecular and Cellular Biology, January 2003, p. 636-644, Vol. 23, No. 2
0022-538X/03/$08.00+0     DOI: 10.1128/MCB.23.2.636-644.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kimura, N., Shukunami, C., Hakuno, D., Yoshioka, M., Miura, S., Docheva, D., Kimura, T., Okada, Y., Matsumura, G., Shin'oka, T., Yozu, R., Kobayashi, J., Ishibashi-Ueda, H., Hiraki, Y., Fukuda, K. (2008). Local Tenomodulin Absence, Angiogenesis, and Matrix Metalloproteinase Activation Are Associated With the Rupture of the Chordae Tendineae Cordis. Circulation 118: 1737-1747 [Abstract] [Full Text]  
  • Docheva, D., Hunziker, E. B., Fassler, R., Brandau, O. (2005). Tenomodulin Is Necessary for Tenocyte Proliferation and Tendon Maturation. Mol. Cell. Biol. 25: 699-705 [Abstract] [Full Text]  
  • Jain, S., Watson, M. A., DeBenedetti, M. K., Hiraki, Y., Moley, J. F., Milbrandt, J. (2004). Expression Profiles Provide Insights into Early Malignant Potential and Skeletal Abnormalities in Multiple Endocrine Neoplasia Type 2B Syndrome Tumors. Cancer Res. 64: 3907-3913 [Abstract] [Full Text]  
  • Oshima, Y., Sato, K., Tashiro, F., Miyazaki, J.-i., Nishida, K., Hiraki, Y., Tano, Y., Shukunami, C. (2004). Anti-angiogenic action of the C-terminal domain of tenomodulin that shares homology with chondromodulin-I. J. Cell Sci. 117: 2731-2744 [Abstract] [Full Text]  
  • Kawano, H., Sato, T., Yamada, T., Matsumoto, T., Sekine, K., Watanabe, T., Nakamura, T., Fukuda, T., Yoshimura, K., Yoshizawa, T., Aihara, K.-i., Yamamoto, Y., Nakamichi, Y., Metzger, D., Chambon, P., Nakamura, K., Kawaguchi, H., Kato, S. (2003). Suppressive function of androgen receptor in bone resorption. Proc. Natl. Acad. Sci. USA 100: 9416-9421 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»