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Molecular and Cellular Biology, June 2004, p. 4943-4954, Vol. 24, No. 11
0270-7306/04/$08.00+0     DOI: 10.1128/MCB.24.11.4943-4954.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They Regulate

Pablo Rodriguez-Viciana, Celine Sabatier, and Frank McCormick*

Cancer Research Institute and Comprehensive Cancer Center, University of California, San Francisco, California 94143

Received 5 November 2003/ Returned for modification 9 December 2003/ Accepted 23 February 2004

Ras family GTPases (RFGs) regulate signaling pathways that control multiple biological processes. How signaling specificity among the closely related family members is achieved is poorly understood. We have taken a proteomics approach to signaling by RFGs, and we have analyzed interactions of a panel of RFGs with a comprehensive group of known and potential effectors. We have found remarkable differences in the ability of RFGs to regulate the various isoforms of known effector families. We have also identified several proteins as novel effectors of RFGs with differential binding specificities to the various RFGs. We propose that specificity among RFGs is achieved by the differential regulation of combinations of effector families as well as by the selective regulation of different isoforms within an effector family. An understanding of this new level of complexity in the signaling pathways regulated by RFGs is necessary to understand how they carry out their many cellular functions. It will also likely have critical implications in the treatment of human diseases such as cancer.

* Corresponding author. Mailing address: Cancer Research Institute and Comprehensive Cancer Center, University of California, San Francisco, 2340 Sutter St., San Francisco, CA 94143. Phone: (415) 502-1710. Fax: (415) 502-1712. E-mail: mccormick{at}cc.ucsf.edu.

Molecular and Cellular Biology, June 2004, p. 4943-4954, Vol. 24, No. 11
0022-538X/04/$08.00+0     DOI: 10.1128/MCB.24.11.4943-4954.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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