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Molecular and Cellular Biology, July 2004, p. 6094-6103, Vol. 24, No. 13
0270-7306/04/$08.00+0     DOI: 10.1128/MCB.24.13.6094-6103.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

SOCS5 Is Expressed in Primary B and T Lymphoid Cells but Is Dispensable for Lymphocyte Production and Function

Christine Brender,1,2 Ruth Columbus,1 Donald Metcalf,1 Emanuela Handman,1 Robyn Starr,1 Nick Huntington,1 David Tarlinton,1 Niels Ødum,2 Sandra E. Nicholson,1 Nicos A. Nicola,1 Douglas J. Hilton,1 and Warren S. Alexander1*

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia,1 Institutes of Medical Microbiology and Immunology and Molecular Biology, University of Copenhagen, Copenhagen, Denmark2

Received 13 January 2004/ Returned for modification 21 February 2004/ Accepted 9 April 2004

Suppressors of cytokine signaling (SOCSs) are key regulators of cytokine-induced responses in hematopoietic as well as nonhematopoietic cells. SOCS1 and SOCS3 have been shown to modulate T-cell responses, whereas the roles of other SOCS family members in the regulation of lymphocyte function are less clear. Here, we report the generation of mice with a targeted disruption of the Socs5 gene. Socs5–/– mice were born in a normal Mendelian ratio and were healthy and fertile. We found that SOCS5 is expressed in primary B and T cells in wild-type mice. However, no abnormalities in the lymphocyte compartment were seen in SOCS5-deficient mice. We examined antigen- and cytokine-induced proliferative responses in B and T cells in the absence of SOCS5 and found no deviations from the responses seen in wild-type cells. Because SOCS5 has been implicated in Th1 differentiation, we also investigated the importance of SOCS5 in T helper cell responses. Unexpectedly, SOCS5-deficient CD4 T cells showed no abnormalities in Th1/Th2 differentiation and Socs5–/– mice showed normal resistance to infection with Leishmania major. Therefore, although SOCS5 is expressed in primary B and T cells, it appears to be dispensable for the regulation of lymphocyte function.

* Corresponding author. Mailing address: The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia. Phone: 61-3-9345-2555. Fax: 61-3-9347-0852. E-mail: alexandw{at}wehi.edu.au.

Molecular and Cellular Biology, July 2004, p. 6094-6103, Vol. 24, No. 13
0022-538X/04/$08.00+0     DOI: 10.1128/MCB.24.13.6094-6103.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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