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Molecular and Cellular Biology, October 2004, p. 8907-8916, Vol. 24, No. 20
0270-7306/04/$08.00+0     DOI: 10.1128/MCB.24.20.8907-8916.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Epiregulin Is Not Essential for Development of Intestinal Tumors but Is Required for Protection from Intestinal Damage

Daekee Lee,1 R. Scott Pearsall,1 Sanjoy Das,2 Sudhansu K. Dey,2,3 Virginia L. Godfrey,4,5 and David W. Threadgill1,3,6*

Departments of Genetics,1 Pathology,4 Lineberger Comprehensive Cancer Center,5 Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill, North Carolina,6 Departments of Pediatrics,2 Cell and Developmental Biology and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee3

Received 2 May 2004/ Accepted 23 June 2004

Epiregulin, an epidermal growth factor family member, acts as a local signal mediator and shows dual biological activity, stimulating the proliferation of fibroblasts, hepatocytes, smooth muscle cells, and keratinocytes while inhibiting the growth of several tumor-derived epithelial cell lines. The epiregulin gene (Ereg) is located on mouse chromosome 5 adjacent to three other epidermal growth factor family members, epigen, amphiregulin, and betacellulin. Gene targeting was used to insert a lacZ reporter into the mouse Ereg locus and to ablate its function. Although epiregulin is broadly expressed and regulated both spatially and temporally, Ereg null mice show no overt developmental defects, reproductive abnormalities, or altered liver regeneration. Additionally, in contrast to previous hypotheses, Ereg deficiency does not alter intestinal cancer susceptibility, as assayed in the ApcMin model, despite showing robust expression in developing tumors. However, Ereg null mice are highly susceptible to cancer-predisposing intestinal damage caused by oral administration of dextran sulfate sodium.

* Corresponding author. Mailing address: Department of Genetics, CB#7264, University of North Carolina, Chapel Hill, NC 27599. Phone: (919) 843-6472. Fax: (919) 966-3292. E-mail: dwt{at}med.unc.edu.

Molecular and Cellular Biology, October 2004, p. 8907-8916, Vol. 24, No. 20
0022-538X/04/$08.00+0     DOI: 10.1128/MCB.24.20.8907-8916.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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