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Molecular and Cellular Biology, October 2004, p. 9137-9151, Vol. 24, No. 20
0270-7306/04/$08.00+0     DOI: 10.1128/MCB.24.20.9137-9151.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

PHR1, a PH Domain-Containing Protein Expressed in Primary Sensory Neurons

Shunbin Xu,1,2 Yanshu Wang,1,3 Haiqing Zhao,1,3 Lilei Zhang,2,4 Weihong Xiong,5 King-Wai Yau,1,5 Hakim Hiel,6 Elisabeth Glowatzki,6 David K. Ryugo,5,6 and David Valle1,2*

Howard Hughes Medical Institute,1 McKusick-Nathans Institute of Genetic Medicine,2 Department of Molecular Biology and Genetics,3 Predoctoral Training Program in Human Genetics,4 Department of Neuroscience,5 Department of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, Maryland6

Received 9 June 2003/ Returned for modification 21 July 2003/ Accepted 28 June 2004

Previously, we identified PHR1 as an abundantly expressed gene in photoreceptors and showed that it encodes four isoforms, each with N-terminal pleckstrin homology (PH) and C-terminal transmembrane domains. To better understand PHR1 function and expression, we made a Phr1 null mouse by inserting a ß-galactosidase/neor cassette into exon 3. In addition to photoreceptors, we found abundant expression of specific Phr1 splice forms in olfactory receptor neurons and vestibular and cochlear hair cells. We also found Phr1 expression in cells with a possible sensory function, including peripheral retinal ganglion cells, cochlear interdental cells, and neurons of the circumventricular organ. Despite this discrete expression in known and putative sensory neurons, mice lacking PHR1 do not have overt sensory deficits.

* Corresponding author. Mailing address: McKusick-Nathans Institute of Genetic Medicine, Howard Hughes Medical Institute, PCTB 519, 733 N. Broadway, Baltimore, MD 21205. Phone: (410) 955-4260. Fax: (410) 955-7397. E-mail: dvalle{at}jhmi.edu.

Molecular and Cellular Biology, October 2004, p. 9137-9151, Vol. 24, No. 20
0022-538X/04/$08.00+0     DOI: 10.1128/MCB.24.20.9137-9151.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Xu, S., Witmer, P. D., Lumayag, S., Kovacs, B., Valle, D. (2007). MicroRNA (miRNA) Transcriptome of Mouse Retina and Identification of a Sensory Organ-specific miRNA Cluster. J. Biol. Chem. 282: 25053-25066 [Abstract] [Full Text]  
  • Etournay, R., El-Amraoui, A., Bahloul, A., Blanchard, S., Roux, I., Pezeron, G., Michalski, N., Daviet, L., Hardelin, J.-P., Legrain, P., Petit, C. (2005). PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa. J. Cell Sci. 118: 2891-2899 [Abstract] [Full Text]  


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