This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shao, R.
Right arrow Articles by Wang, X.-F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shao, R.
Right arrow Articles by Wang, X.-F.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, May 2004, p. 3992-4003, Vol. 24, No. 9
0270-7306/04/$08.00+0     DOI: 10.1128/MCB.24.9.3992-4003.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Acquired Expression of Periostin by Human Breast Cancers Promotes Tumor Angiogenesis through Up-Regulation of Vascular Endothelial Growth Factor Receptor 2 Expression

Rong Shao,1 Shideng Bao,1 Xuefang Bai,1 Carrie Blanchette,2 Ryan M. Anderson,1 Tongyun Dang,1 Mikhail L. Gishizky,3 Jeffrey R. Marks,2 and Xiao-Fan Wang1*

Department of Pharmacology and Cancer Biology,1 Department of Experimental Surgery, Duke University Medical Center, Durham, North Carolina 27710,2 SUGEN, Inc., South San Francisco, California 940803

Received 5 November 2003/ Returned for modification 16 December 2003/ Accepted 27 January 2004

The late stages of human breast cancer development are poorly understood complex processes associated with the expression of genes by cancers that promote specific tumorigenic activities, such as angiogenesis. Here, we describe the identification of periostin as a mesenchyme-specific gene whose acquired expression by human breast cancers leads to a significant enhancement in tumor progression and angiogenesis. Undetectable in normal human breast tissues, periostin was found to be overexpressed by the vast majority of human primary breast cancers examined. Tumor cell lines engineered to overexpress periostin showed a phenotype of accelerated growth and angiogenesis as xenografts in immunocompromised animals. The underlying mechanism of periostin-mediated induction of angiogenesis was found to derive in part from the up-regulation of the vascular endothelial growth factor receptor Flk-1/KDR by endothelial cells through an integrin {alpha}vß3-focal adhesion kinase-mediated signaling pathway. These findings demonstrate the presence of a novel mechanism by which tumor angiogenesis is acquired with the expression of a mesenchyme-specific gene as a crucial step in late stages of tumorigenesis.

* Corresponding author. Mailing address: Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710. Phone: (919) 681-4861. Fax: (919) 681-7152. E-mail: wang0011{at}mc.duke.edu.

Molecular and Cellular Biology, May 2004, p. 3992-4003, Vol. 24, No. 9
0022-538X/04/$08.00+0     DOI: 10.1128/MCB.24.9.3992-4003.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Stansfield, W. E., Andersen, N. M., Tang, R.-H., Selzman, C. H. (2009). Periostin is a novel factor in cardiac remodeling after experimental and clinical unloading of the failing heart.. Ann. Thorac. Surg. 88: 1916-1921 [Abstract] [Full Text]  
  • Rani, S., Barbe, M. F., Barr, A. E., Litvin, J. (2009). Induction of Periostin-like Factor and Periostin in Forearm Muscle, Tendon, and Nerve in an Animal Model of Work-related Musculoskeletal Disorder. J. Histochem. Cytochem. 57: 1061-1073 [Abstract] [Full Text]  
  • Soltermann, A., Tischler, V., Arbogast, S., Braun, J., Probst-Hensch, N., Weder, W., Moch, H., Kristiansen, G. (2008). Prognostic Significance of Epithelial-Mesenchymal and Mesenchymal-Epithelial Transition Protein Expression in Non-Small Cell Lung Cancer. Clin. Cancer Res. 14: 7430-7437 [Abstract] [Full Text]  
  • Quaresima, B., Romeo, F., Faniello, M. C., Di Sanzo, M., Liu, C.-G., Lavecchia, A., Taccioli, C., Gaudio, E., Baudi, F., Trapasso, F., Croce, C. M., Cuda, G., Costanzo, F. (2008). BRCA1 5083del19 Mutant Allele Selectively Up-Regulates Periostin Expression In vitro and In vivo. Clin. Cancer Res. 14: 6797-6803 [Abstract] [Full Text]  
  • Wallace, D. P., Quante, M. T., Reif, G. A., Nivens, E., Ahmed, F., Hempson, S. J., Blanco, G., Yamaguchi, T. (2008). Periostin induces proliferation of human autosomal dominant polycystic kidney cells through {alpha}V-integrin receptor. Am. J. Physiol. Renal Physiol. 295: F1463-F1471 [Abstract] [Full Text]  
  • Kikuchi, Y., Kashima, T. G., Nishiyama, T., Shimazu, K., Morishita, Y., Shimazaki, M., Kii, I., Horie, H., Nagai, H., Kudo, A., Fukayama, M. (2008). Periostin Is Expressed in Pericryptal Fibroblasts and Cancer-associated Fibroblasts in the Colon. J. Histochem. Cytochem. 56: 753-764 [Abstract] [Full Text]  
  • Coutu, D. L., Wu, J. H., Monette, A., Rivard, G.-E., Blostein, M. D., Galipeau, J. (2008). Periostin, a Member of a Novel Family of Vitamin K-dependent Proteins, Is Expressed by Mesenchymal Stromal Cells. J. Biol. Chem. 283: 17991-18001 [Abstract] [Full Text]  
  • Puppin, C., Fabbro, D., Dima, M., Di Loreto, C., Puxeddu, E., Filetti, S., Russo, D., Damante, G. (2008). High periostin expression correlates with aggressiveness in papillary thyroid carcinomas. J Endocrinol 197: 401-408 [Abstract] [Full Text]  
  • Ma, C., Rong, Y., Radiloff, D. R., Datto, M. B., Centeno, B., Bao, S., Cheng, A. W. M., Lin, F., Jiang, S., Yeatman, T. J., Wang, X.-F. (2008). Extracellular matrix protein {beta}ig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. Genes Dev. 22: 308-321 [Abstract] [Full Text]  
  • Woodruff, P. G., Boushey, H. A., Dolganov, G. M., Barker, C. S., Yang, Y. H., Donnelly, S., Ellwanger, A., Sidhu, S. S., Dao-Pick, T. P., Pantoja, C., Erle, D. J., Yamamoto, K. R., Fahy, J. V. (2007). From the Cover: Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc. Natl. Acad. Sci. USA 104: 15858-15863 [Abstract] [Full Text]  
  • Roy, S., Patel, D., Khanna, S., Gordillo, G. M., Biswas, S., Friedman, A., Sen, C. K. (2007). Transcriptome-wide analysis of blood vessels laser captured from human skin and chronic wound-edge tissue. Proc. Natl. Acad. Sci. USA 104: 14472-14477 [Abstract] [Full Text]  
  • Bagnato, C., Thumar, J., Mayya, V., Hwang, S.-I., Zebroski, H., Claffey, K. P., Haudenschild, C., Eng, J. K., Lundgren, D. H., Han, D. K. (2007). Proteomics Analysis of Human Coronary Atherosclerotic Plaque: A Feasibility Study of Direct Tissue Proteomics by Liquid Chromatography and Tandem Mass Spectrometry. Mol. Cell. Proteomics 6: 1088-1102 [Abstract] [Full Text]  
  • Lagergren, A., Mansson, R., Zetterblad, J., Smith, E., Basta, B., Bryder, D., Akerblad, P., Sigvardsson, M. (2007). The Cxcl12, Periostin, and Ccl9 Genes Are Direct Targets for Early B-cell Factor in OP-9 Stroma Cells. J. Biol. Chem. 282: 14454-14462 [Abstract] [Full Text]  
  • Castronovo, V., Waltregny, D., Kischel, P., Roesli, C., Elia, G., Rybak, J.-N., Neri, D. (2006). A Chemical Proteomics Approach for the Identification of Accessible Antigens Expressed in Human Kidney Cancer. Mol. Cell. Proteomics 5: 2083-2091 [Abstract] [Full Text]  
  • Kudo, Y., Ogawa, I., Kitajima, S., Kitagawa, M., Kawai, H., Gaffney, P. M., Miyauchi, M., Takata, T. (2006). Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer.. Cancer Res. 66: 6928-6935 [Abstract] [Full Text]  
  • Yan, W., Shao, R. (2006). Transduction of a Mesenchyme-specific Gene Periostin into 293T Cells Induces Cell Invasive Activity through Epithelial-Mesenchymal Transformation. J. Biol. Chem. 281: 19700-19708 [Abstract] [Full Text]  
  • Smirnov, D. A., Foulk, B. W., Doyle, G. V., Connelly, M. C., Terstappen, L. W.M.M., O'Hara, S. M. (2006). Global gene expression profiling of circulating endothelial cells in patients with metastatic carcinomas.. Cancer Res. 66: 2918-2922 [Abstract] [Full Text]  
  • Gaussin, V., Morley, G. E., Cox, L., Zwijsen, A., Vance, K. M., Emile, L., Tian, Y., Liu, J., Hong, C., Myers, D., Conway, S. J., Depre, C., Mishina, Y., Behringer, R. R., Hanks, M. C., Schneider, M. D., Huylebroeck, D., Fishman, G. I., Burch, J. B.E., Vatner, S. F. (2005). Alk3/Bmpr1a Receptor Is Required for Development of the Atrioventricular Canal Into Valves and Annulus Fibrosus. Circ. Res. 97: 219-226 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»