This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental material
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Karni, R.
Right arrow Articles by Levitzki, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Karni, R.
Right arrow Articles by Levitzki, A.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, June 2005, p. 5031-5039, Vol. 25, No. 12
0270-7306/05/$08.00+0     doi:10.1128/MCB.25.12.5031-5039.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Active Src Elevates the Expression of ß-Catenin by Enhancement of Cap-Dependent Translation{ddagger}

Rotem Karni,1,{dagger},§ Yael Gus,1,{dagger} Yuval Dor,2 Oded Meyuhas,3 and Alexander Levitzki1*

Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem,1 Department of Molecular Biology,2 Department of Biochemistry, Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel3

Received 26 September 2004/ Returned for modification 4 November 2004/ Accepted 3 March 2005

The proto-oncogene pp60c-Src (c-Src) is activated in many types of cancer and contributes to the transformed phenotype of the tumor, although its role is not yet fully understood. Here we report that active Src elevates the levels of ß-catenin by enhancing cap-dependent translation. Src induces phosphorylation of the eukaryotic initiation factor 4E via the Ras/Raf/ERK pathway and the phosphorylation of its inhibitor 4E-BP1 via the PI3K/mTOR pathway. Activated Src enhances the accumulation of nuclear ß-catenin and enhances its transcriptional activity, elevating target genes such as cyclin D1. This novel activation of the Wnt pathway by Src most probably contributes to the oncogenic phenotype of cancer cells.

* Corresponding author. Mailing address: Unit of Cellular Signaling, Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel. Phone: 972-2-6585404. Fax: 972-2-6512958. E-mail: levitzki{at}vms.huji.ac.il.

{ddagger} Supplemental material for this article may be found at http://mcb.asm.org/.

§ Present address: Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724.

{dagger} R.K. and Y.G. contributed equally to this work.

Molecular and Cellular Biology, June 2005, p. 5031-5039, Vol. 25, No. 12
0022-538X/05/$08.00+0     doi:10.1128/MCB.25.12.5031-5039.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Karni, R., Hippo, Y., Lowe, S. W., Krainer, A. R. (2008). The splicing-factor oncoprotein SF2/ASF activates mTORC1. Proc. Natl. Acad. Sci. USA 105: 15323-15327 [Abstract] [Full Text]  
  • McCoy, P. A., McMahon, L. L. (2007). Muscarinic Receptor Dependent Long-Term Depression in Rat Visual Cortex Is PKC Independent but Requires ERK1/2 Activation and Protein Synthesis. J. Neurophysiol. 98: 1862-1870 [Abstract] [Full Text]  
  • Force, T., Woulfe, K., Koch, W. J., Kerkela, R. (2007). Molecular Scaffolds Regulate Bidirectional Crosstalk Between Wnt and Classical Seven-Transmembrane Domain Receptor Signaling Pathways. Sci Signal 2007: pe41-pe41 [Abstract] [Full Text]  
  • Miyahara, T., Hamanaka, K., Weber, D. S., Drake, D. A., Anghelescu, M., Parker, J. C. (2007). Phosphoinositide 3-kinase, Src, and Akt modulate acute ventilation-induced vascular permeability increases in mouse lungs. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L11-L21 [Abstract] [Full Text]  
  • Neron, S., Suck, G., Ma, X.-Z., Sakac, D., Roy, A., Katsman, Y., Dussault, N., Racine, C., Branch, D. R. (2006). B cell proliferation following CD40 stimulation results in the expression and activation of Src protein tyrosine kinase. Int Immunol 18: 375-387 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»