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Molecular and Cellular Biology, December 2005, p. 10604-10610, Vol. 25, No. 23
0270-7306/05/$08.00+0     doi:10.1128/MCB.25.23.10604-10610.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Murine Stanniocalcin 1 Gene Is Not Essential for Growth and Development

Andy C.-M. Chang,¹ Jeon Cha,¹ Frank Koentgen,^2, and Roger R. Reddel^1*

Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, NSW 2145, Australia,¹ Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050, Australia²

Received 17 June 2005/ Returned for modification 11 July 2005/ Accepted 10 September 2005

The stanniocalcin 1 (STC1) gene is expressed in a wide variety of tissues, including the kidney, prostate, thyroid, bone, and ovary. STC1 protein is considered to have roles in many physiological processes, including bone development, reproduction, wound healing, angiogenesis, and modulation of inflammatory response. In fish, STC1 is a hormone that is secreted by the corpuscles of Stannius and is involved in calcium and phosphate homeostasis. To determine the role of STC1 in mammals, we generated Stc1-null mice by gene targeting. The number of Stc1^–/– mice obtained was in accordance with Mendelian ratios, and both males and females produced offspring normally. No anatomical or histological abnormalities were detected in any tissues. Our results demonstrated that Stc1 function is not essential for growth or reproduction in the mouse.

Present address: Ozgene Pty Ltd., P.O. Box 1368, Canning Vale, WA 6970, Australia.

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