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Molecular and Cellular Biology, March 2005, p. 2395-2405, Vol. 25, No. 6
0270-7306/05/$08.00+0     doi:10.1128/MCB.25.6.2395-2405.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Novel ETS Factor TEL2 Cooperates with Myc in B Lymphomagenesis

Monica Cardone,¹ Ayten Kandilci,¹ Cintia Carella,¹ Jonas A. Nilsson,² Jennifer A. Brennan,² Sema Sirma,³ Ugur Ozbek,³ Kelli Boyd,⁴ John L. Cleveland,² and Gerard C. Grosveld^1*

Departments of Genetics and Tumor Cell Biology,¹ Biochemistry,² Animal Resource Center, St. Jude Children's Research Hospital, Memphis, Tennessee,⁴ Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey³

Received 22 September 2004/ Returned for modification 24 November 2004/ Accepted 13 December 2004

The human ETS family gene TEL2/ETV7 is highly homologous to TEL1/ETV6, a frequent target of chromosome translocations in human leukemia and specific solid tumors. Here we report that TEL2 augments the proliferation and survival of normal mouse B cells and dramatically accelerates lymphoma development in Eµ-Myc transgenic mice. Nonetheless, inactivation of the p53 pathway was a hallmark of all TEL2/Eµ-Myc lymphomas, indicating that TEL2 expression alone is insufficient to bypass this apoptotic checkpoint. Although TEL2 is infrequently up-regulated in human sporadic Burkitt's lymphoma, analysis of pediatric B-cell acute lymphocytic leukemia (B-ALL) samples showed increased coexpression of TEL2 and MYC and/or MYCN in over one-third of B-ALL patients. Therefore, TEL2 and MYC also appear to cooperate in provoking a cadre of human B-cell malignancies.

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* Corresponding author. Mailing address: Department of Genetics, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105. Phone: (901) 495-2279. Fax: (901) 526-2907. E-mail: gerard.grosveld{at}stjude.org.

Supplemental material for this article may be found at http://mcb.asm.org/.

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Molecular and Cellular Biology, March 2005, p. 2395-2405, Vol. 25, No. 6
0022-538X/05/$08.00+0     doi:10.1128/MCB.25.6.2395-2405.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

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