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Molecular and Cellular Biology, April 2005, p. 2688-2697, Vol. 25, No. 7
0270-7306/05/$08.00+0     doi:10.1128/MCB.25.7.2688-2697.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Ikaros SUMOylation: Switching Out of Repression

Pablo Gómez-del Arco, Joseph Koipally, and Katia Georgopoulos*

Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts

Received 12 September 2004/ Returned for modification 12 October 2004/ Accepted 24 December 2004

Ikaros plays a key role in lymphocyte development and homeostasis by both potentiating and repressing gene expression. Here we show that Ikaros interacts with components of the SUMO pathway and is SUMOylated in vivo. Two SUMOylation sites are identified on Ikaros whose simultaneous modification results in a loss of Ikaros' repression function. Ikaros SUMOylation disrupts its participation in both histone deacetylase (HDAC)-dependent and HDAC-independent repression but does not influence its nuclear localization into pericentromeric heterochromatin. These studies reveal a new dynamic way by which Ikaros-mediated gene repression is controlled by SUMOylation.

* Corresponding author. Mailing address: Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129. Phone: (617) 724-8279. Fax: (617) 726-4453. E-mail: katia.georgopoulos{at}cbrc2.mgh.harvard.edu.

Molecular and Cellular Biology, April 2005, p. 2688-2697, Vol. 25, No. 7
0022-538X/05/$08.00+0     doi:10.1128/MCB.25.7.2688-2697.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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