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Molecular and Cellular Biology, March 2006, p. 1817-1825, Vol. 26, No. 5
0270-7306/06/$08.00+0     doi:10.1128/MCB.26.5.1817-1825.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

-Parvin Is Dispensable for Hematopoiesis, Leukocyte Trafficking, and T-Cell-Dependent Antibody Response

Haiyan Chu,¹ Ingo Thievessen,¹ Michael Sixt,¹ Tim Lämmermann,¹ Ari Waisman,^2, Attila Braun,¹ Angelika A. Noegel,³ and Reinhard Fässler^1*

Department of Molecular Medicine, Max Planck Institute for Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany,¹ Laboratory of Molecular Immunology, Institute for Genetics, University of Cologne, Zülpicher Str. 47, 50674 Cologne, Germany,² Center for Biochemistry, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 52, 50931 Cologne, Germany³

Received 12 August 2005/ Returned for modification 21 September 2005/ Accepted 30 November 2005

Integrins regulate cell behavior through the assembly of multiprotein complexes at the site of cell adhesion. Parvins are components of such a multiprotein complex. They consist of three members (-, ß-, and -parvin), form a functional complex with integrin-linked kinase (ILK) and PINCH, and link integrins to the actin cytoskeleton. Whereas - and ß-parvins are widely expressed, -parvin has been reported to be expressed in hematopoietic organs. In the present study, we report the expression pattern of the parvins in hematopoietic cells and the phenotypic analysis of -parvin-deficient mice. Whereas -parvin is not expressed in hematopoietic cells, ß-parvin is only found in myeloid cells and -parvin is present in both cells of the myeloid and lymphoid lineages, where it binds ILK. Surprisingly, loss of -parvin expression had no effect on blood cell differentiation, proliferation, and survival and no consequence for the T-cell-dependent antibody response and lymphocyte and dendritic cell migration. These data indicate that despite the high expression of -parvin in hematopoietic cells it must play a more subtle role for blood cell homeostasis.

Supplemental material for this article may be found at http://mcb.asm.org/.

Present address: Medizinsche Klinik und Poliklinik, Johannes Gutenberg-Universitat Mainz, 55131 Mainz, Germany.

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