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Molecular and Cellular Biology, July 2007, p. 5120-5127, Vol. 27, No. 14
0270-7306/07/$08.00+0     doi:10.1128/MCB.00215-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

A Brain-Specific Homeobox Gene, Bsx, Is Essential for Proper Postnatal Growth and Nursing{triangledown}

Tara McArthur and Akihira Ohtoshi*

Center of Molecular and Human Genetics, Children's Research Institute, Columbus, Ohio 43205

Received 5 February 2007/ Returned for modification 28 March 2007/ Accepted 27 April 2007

To investigate in vivo roles of a murine hypothalamic homeobox gene, Bsx, we generated and analyzed two mutant alleles, Bsx{Delta}HD and BsxlacZ. Bsx{Delta}HD lacks the homeodomain, and BsxlacZ is an insertion of a lacZ reporter gene. Bsx-lacZ expression was detected in the hypothalamus and pineal gland and reiterates Bsx expression. Bsx homozygous mutant mice were born at the expected Mendelian ratio, but their growth was impaired. Offspring from Bsx homozygous mutant females exhibited a low survival rate due to a nursing defect. Mammary glands of the mutant females developed normally during pregnancy; however, they involuted quickly after parturition. These results demonstrate that Bsx is required for postnatal growth and maintenance of lactating mammary glands. Thus, mouse Bsx is likely involved in systemic control of suppression of apoptosis of postpartum mammary epithelial cells.

* Corresponding author. Mailing address: Center of Molecular and Human Genetics, Children's Research Institute, 700 Children's Drive, Columbus, OH 43205. Phone: (614) 355-3509. Fax: (614) 722-2817. E-mail: otoshia{at}ccri.net

{triangledown} Published ahead of print on 7 May 2007.

Molecular and Cellular Biology, July 2007, p. 5120-5127, Vol. 27, No. 14
0270-7306/07/$08.00+0     doi:10.1128/MCB.00215-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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