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Molecular and Cellular Biology, July 2007, p. 5128-5134, Vol. 27, No. 14
0270-7306/07/$08.00+0     doi:10.1128/MCB.01072-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

CD3 and Immunoglobulin G Fc Receptor Regulate Cerebellar Functions{triangledown}

Kazuhiro Nakamura,1* Hirokazu Hirai,2 Takashi Torashima,2 Taisuke Miyazaki,3 Hiromichi Tsurui,1 Yan Xiu,1 Mareki Ohtsuji,1 Qing Shun Lin,1 Kazuyuki Tsukamoto,1 Hiroyuki Nishimura,4 Masao Ono,5 Masahiko Watanabe,3 and Sachiko Hirose1

Department of Pathology, Juntendo University School of Medicine, Tokyo 113-8421, Japan,1 Department of Neurophysiology, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan,2 Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060-8638, Japan,3 Department of Biomedical Engineering, Toin University of Yokohama, Yokohama 225-8502, Japan,4 Department of Pathology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan5

Received 15 June 2006/ Returned for modification 16 July 2006/ Accepted 23 April 2007

The immune and nervous systems display considerable overlap in their molecular repertoire. Molecules originally shown to be critical for immune responses also serve neuronal functions that include normal brain development, neuronal differentiation, synaptic plasticity, and behavior. We show here that Fc{gamma}RIIB, a low-affinity immunoglobulin G Fc receptor, and CD3 are involved in cerebellar functions. Although membranous CD3 and Fc{gamma}RIIB are crucial regulators on different cells in the immune system, both CD3{varepsilon} and Fc{gamma}RIIB are expressed on Purkinje cells in the cerebellum. Both CD3{varepsilon}-deficient mice and Fc{gamma}RIIB-deficient mice showed an impaired development of Purkinje neurons. In the adult, rotarod performance of these mutant mice was impaired at high speed. In the two knockout mice, enhanced paired-pulse facilitation of parallel fiber-Purkinje cell synapses was shared. These results indicate that diverse immune molecules play critical roles in the functional establishment in the cerebellum.

* Corresponding author. Mailing address: Department of Pathology, Juntendo University School of Medicine, Tokyo 113-8421, Japan. Phone: 81-3-5802-1039. Fax: 81-3-3813-3164. E-mail: kaz{at}med.juntendo.ac.jp

{triangledown} Published ahead of print on 14 May 2007.

Molecular and Cellular Biology, July 2007, p. 5128-5134, Vol. 27, No. 14
0270-7306/07/$08.00+0     doi:10.1128/MCB.01072-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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