This Article Full Text (PDF) A correction has been published Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Knopf, J L Articles by Held, W A Search for Related Content PubMed PubMed Citation Articles by Knopf, J L Articles by Held, W A

 Previous Article  |  Next Article 

Mol Cell Biol. 1983 December; 3(12): 2232-2240

Differential, multihormonal regulation of the mouse major urinary protein gene family in the liver.

J L Knopf, J F Gallagher and W A Held

ABSTRACT

The hormonal requirements for the regulation of the major urinary protein (MUP) mRNA levels in mouse liver have been examined. Previous experiments have shown that administration of testosterone to female or castrated male mice increases MUP mRNA levels approximately fivefold to normal male levels. We have found that thyroxine and the peptide hormone, growth hormone, each had a pronounced effect on MUP mRNA levels. MUP mRNA was reduced 150-fold in growth-hormone-deficient mutant mice (little). The administration of growth hormone and thyroxine induced MUP mRNA approximately 150-fold, and when administered together, they induced MUP mRNA approximately 1,000-fold. testosterone administration. When administered separately to these mice, growth hormone and thyroxine induced with MUP mRNA approximately 150-fold, and when administered together, they induced MUP mRNA approximately 1,000-fold. Testicular feminized mice, which lack a functional major testosterone receptor protein, can also be induced to male levels by treatment with both growth hormone and thyroxine. In addition, we present evidence which indicates that growth hormone, thyroxine, and testosterone differentially regulate the levels of distinct MUP mRNA species.

---

Mol Cell Biol. 1983 December; 3(12): 2232-2240

This article has been cited by other articles:

• Ho, K. J., Bass, C. E., Kroemer, A. H. K., Ma, C., Terwilliger, E., Karp, S. J. (2008). Optimized adeno-associated virus 8 produces hepatocyte-specific Cre-mediated recombination without toxicity or affecting liver regeneration. Am. J. Physiol. Gastrointest. Liver Physiol. 295: G412-G419 [Abstract] [Full Text]  
• Emes, R. D., Beatson, S. A., Ponting, C. P., Goodstadt, L. (2004). Evolution and Comparative Genomics of Odorant- and Pheromone-Associated Genes in Rodents. Genome Res 14: 591-602 [Abstract] [Full Text]  
• Miller, R. A., Chang, Y., Galecki, A. T., Al-Regaiey, K., Kopchick, J. J., Bartke, A. (2002). Gene Expression Patterns in Calorically Restricted Mice: Partial Overlap with Long-Lived Mutant Mice. Mol. Endocrinol. 16: 2657-2666 [Abstract] [Full Text]  
• Moss, R. L., Flynn, R. E., Shen, X.-M., Dudley, C., Shi, J., Novotny, M. (1997). Urine-Derived Compound Evokes Membrane Responses in Mouse Vomeronasal Receptor Neurons. J. Neurophysiol. 77: 2856-2862 [Abstract] [Full Text]  
• Reik, W., Romer, I., Barton, S. C., Surani, M. A., Howlett, S. K., Klose, J. (1993). Adult phenotype in the mouse can be affected by epigenetic events in the early embryo. Development 119: 933-942 [Abstract]