MCB
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Funanage, V L
Right arrow Articles by Cowell, H R
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Funanage, V L
Right arrow Articles by Cowell, H R

 Previous Article  |  Next Article 

Mol Cell Biol. 1984 October; 4(10): 2010-2016

Assignment of the human dihydrofolate reductase gene to the q11----q22 region of chromosome 5.

V L Funanage, T T Myoda, P A Moses and H R Cowell

ABSTRACT

Cells from a dihydrofolate reductase-deficient Chinese hamster ovary cell line were hybridized to human fetal skin fibroblast cells. Nineteen dihydrofolate reductase-positive hybrid clones were isolated and characterized. Cytogenetic and biochemical analyses of these clones have shown that the human dihydrofolate reductase (DHFR) gene is located on chromosome 5. Three of these hybrid cell lines contained different terminal deletions of chromosome 5. An analysis of the breakpoints of these deletions has demonstrated that the DHFR gene resides in the q11----q22 region.

Mol Cell Biol. 1984 October; 4(10): 2010-2016






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 1984 by the American Society for Microbiology. All rights reserved.