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Mol Cell Biol. 1984 February; 4(2): 383-385

Chromosomal assignment of the murine gene encoding the transformation-related protein p53.

V Rotter, D Wolf, D Pravtcheva and F H Ruddle

ABSTRACT

p53 is a transformation-related protein that is encoded by the cellular genome and is synthesized at elevated levels in a wide range of different cell line types and in primary tumors of various species. By using several independently established anti-p53 monoclonal antibodies, it was possible to distinguish between p53 of mouse origin and p53 of Chinese hamster origin. By analysis of a series of mouse X Chinese hamster hybrid cell lines containing various mouse chromosomes, we mapped the p53 gene product to mouse chromosome 11.

Mol Cell Biol. 1984 February; 4(2): 383-385




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