This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Danielsen, M Articles by Stallcup, M R Search for Related Content PubMed PubMed Citation Articles by Danielsen, M Articles by Stallcup, M R

 Previous Article  |  Next Article 

Mol Cell Biol. 1984 March; 4(3): 449-453

Down-regulation of glucocorticoid receptors in mouse lymphoma cell variants.

ABSTRACT

The mouse thymoma-derived cell line W7 is sensitive to the cytolytic action of glucocorticoids. We have isolated a novel class of cell variant that apparently overcomes its inherent sensitivity to glucocorticoids by reversibly down-regulating the level of glucocorticoid receptors. This phenotype is stable during subcloning in the presence and in the absence of glucocorticoids and is dominant in somatic cell hybrids with wild-type cells. Fusion of this variant with wild-type cells produces hybrids that down-regulate and are less sensitive to glucocorticoids than hybrids of receptor-negative and wild-type cells. This is the first demonstration of a phenotypic change which correlates with down-regulation of the glucocorticoid receptor.

This article has been cited by other articles:

• Zhou, J., Oakley, R. H., Cidlowski, J. A. (2008). DAX-1 (Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita Critical Region on the X-Chromosome, Gene 1) Selectively Inhibits Transactivation But Not Transrepression Mediated by the Glucocorticoid Receptor in a LXXLL-Dependent Manner. Mol. Endocrinol. 22: 1521-1534 [Abstract] [Full Text]  
• Sun, X., Fischer, D. R., Pritts, T. A., Wray, C. J., Hasselgren, P.-O. (2002). Expression and binding activity of the glucocorticoid receptor are upregulated in septic muscle. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282: R509-R518 [Abstract] [Full Text]  
• Tome, M. E., Baker, A. F., Powis, G., Payne, C. M., Briehl, M. M. (2001). Catalase-overexpressing Thymocytes Are Resistant to Glucocorticoid-induced Apoptosis and Exhibit Increased Net Tumor Growth. Cancer Res. 61: 2766-2773 [Abstract] [Full Text]  
• Shrimpton, J., Mccormick, S. (1999). Responsiveness of gill Na+/K+-ATPase to cortisol is related to gill corticosteroid receptor concentration in juvenile rainbow trout. J. Exp. Biol. 202: 987-995 [Abstract]  
• Hsu, S.-c., DeFranco, D. B. (1995). Selectivity of Cell Cycle Regulation of Glucocorticoid Receptor Function. J. Biol. Chem. 270: 3359-3364 [Abstract] [Full Text]