This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Capasso, O Articles by Cancedda, R Search for Related Content PubMed PubMed Citation Articles by Capasso, O Articles by Cancedda, R

 Previous Article  |  Next Article 

Mol Cell Biol. 1984 June; 4(6): 1163-1168

Location of 64K collagen producer chondrocytes in developing chicken embryo tibiae.

ABSTRACT

The synthesis of a new low-molecular-weight collagen by cultured chicken embryo chondrocytes has been recently demonstrated (Capasso et al., Exp. Cell Res. 142:197-206, 1982; Gibson et al., J. Cell Biol. 93:767-774, 1982; Schmid and Conrad, J. Biol. Chem. 257:12444-12450, 1982). In this paper we report results on the location of chondrocytes synthesizing this new collagen (64K collagen) in the developing chicken embryo. The 64K collagen is synthesized in very large amounts by cells concentrated at the diaphysis of 9-day-old and at the epiphysis of 17-day-old embryo tibiae. These regions are characterized by a remodeling of the cartilage matrix leading to the replacement of the cartilage with bone tissue; therefore, this collagen appears to be a marker of a specific developmental stage of chondrocytes. The origin of cells competent for the synthesis of the 64K collagen is also discussed.

This article has been cited by other articles:

• Dreier, R., Gunther, B. K., Mainz, T., Nemere, I., Bruckner, P. (2008). Terminal Differentiation of Chick Embryo Chondrocytes Requires Shedding of a Cell Surface Protein That Binds 1,25-Dihydroxyvitamin D3. J. Biol. Chem. 283: 1104-1112 [Abstract] [Full Text]  
• Cancedda, F. D., Malpeli, M., Gentili, C., Di Marzo, V., Bet, P., Carlevaro, M., Cermelli, S., Cancedda, R. (1996). The Developmentally Regulated Avian Ch21 Lipocalin Is an Extracellular Fatty Acid-binding Protein. J. Biol. Chem. 271: 20163-20169 [Abstract] [Full Text]  
• Quarto, R, Dozin, B, Bonaldo, P, Cancedda, R, Colombatti, A (1993). Type VI collagen expression is upregulated in the early events of chondrocyte differentiation. Development 117: 245-251 [Abstract]