This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Peterson, T A Articles by Reed, S I Search for Related Content PubMed PubMed Citation Articles by Peterson, T A Articles by Reed, S I

 Previous Article  |  Next Article 

Mol Cell Biol. 1985 January; 5(1): 226-235

Regulation of CDC9, the Saccharomyces cerevisiae gene that encodes DNA ligase.

ABSTRACT

We have cloned CDC9, the structural gene for Saccharomyces cerevisiae DNA ligase, and investigated its transcriptional regulation both as a function of cell cycle stage and after UV irradiation. The steady-state level of DNA ligase mRNA increases at least fourfold in late G1, after the completion of start but before S phase. This high level of CDC9 mRNA then decays with an apparent half-life of ca. 20 min and remains at a low basal level throughout the rest of the cell cycle. The accumulation of CDC9 mRNA in late G1 is dependent upon the completion of start but not the CDC7 and CDC8 functions. Exposure of cells to UV light elicits an eightfold increase in DNA ligase mRNA levels.

This article has been cited by other articles:

• Donahue, S. L., Corner, B. E., Bordone, L., Campbell, C. (2001). Mitochondrial DNA ligase function in Saccharomyces cerevisiae. Nucleic Acids Res 29: 1582-1589 [Abstract] [Full Text]  
• Fikus, M. U., Mieczkowski, P. A., Koprowski, P., Rytka, J., ledziewska-Gójska, E., Ciela, Z. (2000). The Product of the DNA Damage-Inducible Gene of Saccharomyces cerevisiae, DIN7, Specifically Functions in Mitochondria. Genetics 154: 73-81 [Abstract] [Full Text]  
• Ho, Y., Mason, S., Kobayashi, R., Hoekstra, M., Andrews, B. (1997). Role of the casein kinase I isoform, Hrr25, and the cell cycle-regulatory transcription factor, SBF, in the transcriptional response to DNA damage in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 94: 581-586 [Abstract] [Full Text]  
• Marini, N J, Reed, S I (1992). Direct induction of G1-specific transcripts following reactivation of the Cdc28 kinase in the absence of de novo protein synthesis.. Genes Dev. 6: 557-567 [Abstract]  
• Taba, M R, Muroff, I, Lydall, D, Tebb, G, Nasmyth, K (1991). Changes in a SWI4,6-DNA-binding complex occur at the time of HO gene activation in yeast.. Genes Dev. 5: 2000-2013 [Abstract]  
• Elledge, S J, Davis, R W (1990). Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase.. Genes Dev. 4: 740-751 [Abstract]