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Mol Cell Biol. 1985 July; 5(7): 1787-1790

Linear simian virus 40 DNA fragments exhibit a propensity for rolling-circle replication.

I Deichaite, Z Laver-Rudich, D Dorsett and E Winocour

ABSTRACT

A linear simian virus 40 origin-containing DNA fragment replicated in monkey COS cells, generating tandemly repeated (head-to-tail) structures. Electron microscopy revealed circle-and-tail configurations characteristic of rolling-circle replication intermediates. Circularization of the same DNA before transfection led to a theta type of replication which generated supercoiled DNA molecules.

Mol Cell Biol. 1985 July; 5(7): 1787-1790




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