This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by James, T C
Right arrow Articles by Elgin, S C
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by James, T C
Right arrow Articles by Elgin, S C

 Previous Article  |  Next Article 

Mol Cell Biol. 1986 November; 6(11): 3862-3872

Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene.

T C James and S C Elgin

ABSTRACT

Monoclonal antibodies were prepared against a fraction of nuclear proteins of Drosophila melanogaster identified as tightly binding to DNA. Four of these antibodies were directed against a 19-kilodalton nuclear protein; immunofluorescence staining of the polytene chromosomes localized the antigen to the alpha, beta, and intercalary heterochromatic regions. Screening of a lambda gt11 cDNA expression library with one of the monoclonal antibodies identified a recombinant DNA phage clone that produced a fusion protein immunologically similar to the heterochromatin-associated protein. Polyclonal sera directed against the bacterial lacZ fusion protein recognized the same nuclear protein on Western blots. A full-length cDNA clone was isolated from a lambda gt10 library, and its DNA sequence was obtained. Analysis of the open reading frame revealed an 18,101-dalton protein encoded by this cDNA. Two overlapping genomic DNA clones were isolated from a Charon 4 library of D. melanogaster with the cDNA clone, and a restriction map was obtained. In situ hybridization with these probes indicated that the gene maps to a single chromosome location at 29A on the 2L chromosome. This general strategy should be effective for cloning the genes and identifying the genetic loci of chromosomal proteins which cannot be readily assayed by other means.

Mol Cell Biol. 1986 November; 6(11): 3862-3872




This article has been cited by other articles:

  • Hines, K. A., Cryderman, D. E., Flannery, K. M., Yang, H., Vitalini, M. W., Hazelrigg, T., Mizzen, C. A., Wallrath, L. L. (2009). Domains of Heterochromatin Protein 1 Required for Drosophila melanogaster Heterochromatin Spreading. Genetics 182: 967-977 [Abstract] [Full Text]  
  • Weiler, K. S., Chatterjee, S. (2009). The Multi-AT-Hook Chromosomal Protein of Drosophila melanogaster, D1, Is Dispensable for Viability. Genetics 182: 145-159 [Abstract] [Full Text]  
  • Brower-Toland, B., Riddle, N. C., Jiang, H., Huisinga, K. L., Elgin, S. C. R. (2009). Multiple SET Methyltransferases Are Required to Maintain Normal Heterochromatin Domains in the Genome of Drosophila melanogaster. Genetics 181: 1303-1319 [Abstract] [Full Text]  
  • Pindyurin, A. V., Boldyreva, L. V., Shloma, V. V., Kolesnikova, T. D., Pokholkova, G. V., Andreyeva, E. N., Kozhevnikova, E. N., Ivanoschuk, I. G., Zarutskaya, E. A., Demakov, S. A., Gorchakov, A. A., Belyaeva, E. S., Zhimulev, I. F. (2008). Interaction between the Drosophila heterochromatin proteins SUUR and HP1. J. Cell Sci. 121: 1693-1703 [Abstract] [Full Text]  
  • Nisha, P., Plank, J. L., Csink, A. K. (2008). Analysis of Chromatin Structure of Genes Silenced by Heterochromatin in Trans. Genetics 179: 359-373 [Abstract] [Full Text]  
  • Weiler, K. S. (2007). E(var)3-9 of Drosophila melanogaster Encodes a Zinc Finger Protein. Genetics 177: 167-178 [Abstract] [Full Text]  
  • Hirose, S. (2007). Crucial Roles for Chromatin Dynamics in Cellular Memory. J Biochem 141: 615-619 [Abstract] [Full Text]  
  • Mateos-Langerak, J., Brink, M. C., Luijsterburg, M. S., van der Kraan, I., van Driel, R., Verschure, P. J. (2007). Pericentromeric Heterochromatin Domains Are Maintained without Accumulation of HP1. Mol. Biol. Cell 18: 1464-1471 [Abstract] [Full Text]  
  • Bongiorni, S., Pasqualini, B., Taranta, M., Singh, P. B., Prantera, G. (2007). Epigenetic regulation of facultative heterochromatinisation in Planococcus citri via the Me(3)K9H3-HP1-Me(3)K20H4 pathway. J. Cell Sci. 120: 1072-1080 [Abstract] [Full Text]  
  • Shaffer, C. D., Cenci, G., Thompson, B., Stephens, G. E., Slawson, E. E., Adu-Wusu, K., Gatti, M., Elgin, S. C. R. (2006). The Large Isoform of Drosophila melanogaster Heterochromatin Protein 2 Plays a Critical Role in Gene Silencing and Chromosome Structure. Genetics 174: 1189-1204 [Abstract] [Full Text]  
  • Norwood, L. E., Moss, T. J., Margaryan, N. V., Cook, S. L., Wright, L., Seftor, E. A., Hendrix, M. J. C., Kirschmann, D. A., Wallrath, L. L. (2006). A Requirement for Dimerization of HP1Hs{alpha} in Suppression of Breast Cancer Invasion. J. Biol. Chem. 281: 18668-18676 [Abstract] [Full Text]  
  • Kaller, M., Euteneuer, U., Nellen, W. (2006). Differential Effects of Heterochromatin Protein 1 Isoforms on Mitotic Chromosome Distribution and Growth in Dictyostelium discoideum. Eukaryot Cell 5: 530-543 [Abstract] [Full Text]  
  • Perez-Alegre, M., Dubus, A., Fernandez, E. (2005). REM1, a New Type of Long Terminal Repeat Retrotransposon in Chlamydomonas reinhardtii. Mol. Cell. Biol. 25: 10628-10638 [Abstract] [Full Text]  
  • De Lucia, F., Ni, J.-Q., Vaillant, C., Sun, F.-L. (2005). HP1 modulates the transcription of cell-cycle regulators in Drosophila melanogaster. Nucleic Acids Res 33: 2852-2858 [Abstract] [Full Text]  
  • Lee, D. Y., Teyssier, C., Strahl, B. D., Stallcup, M. R. (2005). Role of Protein Methylation in Regulation of Transcription. Endocr. Rev. 26: 147-170 [Abstract] [Full Text]  
  • Steensma, D. P., Gibbons, R. J., Higgs, D. R. (2005). Acquired {alpha}-thalassemia in association with myelodysplastic syndrome and other hematologic malignancies. Blood 105: 443-452 [Abstract] [Full Text]  
  • Mukhopadhyay, R., Yu, W., Whitehead, J., Xu, J., Lezcano, M., Pack, S., Kanduri, C., Kanduri, M., Ginjala, V., Vostrov, A., Quitschke, W., Chernukhin, I., Klenova, E., Lobanenkov, V., Ohlsson, R. (2004). The Binding Sites for the Chromatin Insulator Protein CTCF Map to DNA Methylation-Free Domains Genome-Wide. Genome Res 14: 1594-1602 [Abstract] [Full Text]  
  • Pal-Bhadra, M., Leibovitch, B. A., Gandhi, S. G., Rao, M., Bhadra, U., Birchler, J. A., Elgin, S. C. R. (2004). Heterochromatic Silencing and HP1 Localization in Drosophila Are Dependent on the RNAi Machinery. Science 303: 669-672 [Abstract] [Full Text]  
  • Badugu, R., Shareef, M. M., Kellum, R. (2003). Novel Drosophila Heterochromatin Protein 1 (HP1)/Origin Recognition Complex-associated Protein (HOAP) Repeat Motif in HP1/HOAP Interactions and Chromocenter Associations. J. Biol. Chem. 278: 34491-34498 [Abstract] [Full Text]  
  • Chadwick, B. P., Willard, H. F. (2003). Chromatin of the Barr body: histone and non-histone proteins associated with or excluded from the inactive X chromosome. Hum Mol Genet 12: 2167-2178 [Abstract] [Full Text]  
  • Hayakawa, T., Haraguchi, T., Masumoto, H., Hiraoka, Y. (2003). Cell cycle behavior of human HP1 subtypes: distinct molecular domains of HP1 are required for their centromeric localization during interphase and metaphase. J. Cell Sci. 116: 3327-3338 [Abstract] [Full Text]  
  • Ayyanathan, K., Lechner, M. S., Bell, P., Maul, G. G., Schultz, D. C., Yamada, Y., Tanaka, K., Torigoe, K., Rauscher, F. J. III (2003). Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation. Genes Dev. 17: 1855-1869 [Abstract] [Full Text]  
  • Tajul-Arifin, K., Teasdale, R., Ravasi, T., Hume, D. A., RIKEN GER Group, , GSL Members, , Mattick, J. S. (2003). Identification and Analysis of Chromodomain-Containing Proteins Encoded in the Mouse Transcriptome. Genome Res 13: 1416-1429 [Abstract] [Full Text]  
  • Piacentini, L., Fanti, L., Berloco, M., Perrini, B., Pimpinelli, S. (2003). Heterochromatin protein 1 (HP1) is associated with induced gene expression in Drosophila euchromatin. JCB 161: 707-714 [Abstract] [Full Text]  
  • Kellum, R. (2003). Is HP1 an RNA detector that functions both in repression and activation?. JCB 161: 671-672 [Abstract] [Full Text]  
  • Koryakov, D. E., Domanitskaya, E. V., Belyakin, S. N., Zhimulev, I. F. (2003). Abnormal tissue-dependent polytenization of a block of chromosome 3 pericentric heterochromatin in Drosophila melanogaster. J. Cell Sci. 116: 1035-1044 [Abstract] [Full Text]  
  • Lim, C., Lee, D., Seo, T., Choi, C., Choe, J. (2003). Latency-associated Nuclear Antigen of Kaposi's Sarcoma-associated Herpesvirus Functionally Interacts with Heterochromatin Protein 1. J. Biol. Chem. 278: 7397-7405 [Abstract] [Full Text]  
  • Festenstein, R., Pagakis, S. N., Hiragami, K., Lyon, D., Verreault, A., Sekkali, B., Kioussis, D. (2003). Modulation of Heterochromatin Protein 1 Dynamics in Primary Mammalian Cells. Science 299: 719-721 [Abstract] [Full Text]  
  • Shaffer, C. D., Stephens, G. E., Thompson, B. A., Funches, L., Bernat, J. A., Craig, C. A., Elgin, S. C. R. (2002). Heterochromatin protein 2 (HP2), a partner of HP1 in Drosophila heterochromatin. Proc. Natl. Acad. Sci. USA 99: 14332-14337 [Abstract] [Full Text]  
  • Fass, E., Shahar, S., Zhao, J., Zemach, A., Avivi, Y., Grafi, G. (2002). Phosphorylation of Histone H3 at Serine 10 Cannot Account Directly for the Detachment of Human Heterochromatin Protein 1gamma from Mitotic Chromosomes in Plant Cells. J. Biol. Chem. 277: 30921-30927 [Abstract] [Full Text]  
  • Savitsky, M., Kravchuk, O., Melnikova, L., Georgiev, P. (2002). Heterochromatin Protein 1 Is Involved in Control of Telomere Elongation in Drosophila melanogaster. Mol. Cell. Biol. 22: 3204-3218 [Abstract] [Full Text]  
  • Westphal, T., Reuter, G. (2002). Recombinogenic Effects of Suppressors of Position-Effect Variegation in Drosophila. Genetics 160: 609-621 [Abstract] [Full Text]  
  • Lin, C.-Y., Li, C.-C., Huang, P.-H., Lee, F.-J. S. (2002). A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1. J. Cell Sci. 115: 4433-4445 [Abstract] [Full Text]  
  • Netzer, C., Rieger, L., Brero, A., Zhang, C.-D., Hinzke, M., Kohlhase, J., Bohlander, S. K. (2001). SALL1, the gene mutated in Townes-Brocks syndrome, encodes a transcriptional repressor which interacts with TRF1/PIN2 and localizes to pericentromeric heterochromatin. Hum Mol Genet 10: 3017-3024 [Abstract] [Full Text]  
  • Ronsseray, S., Boivin, A., Anxolabehere, D. (2001). P-Element Repression in Drosophila melanogaster by Variegating Clusters of P-lacZ-white Transgenes. Genetics 159: 1631-1642 [Abstract] [Full Text]  
  • Volpe, A. M., Horowitz, H., Grafer, C. M., Jackson, S. M., Berg, C. A. (2001). Drosophila rhino Encodes a Female-Specific Chromo-domain Protein That Affects Chromosome Structure and Egg Polarity. Genetics 159: 1117-1134 [Abstract] [Full Text]  
  • Bongiorni, S., Mazzuoli, M., Masci, S., Prantera, G. (2001). Facultative heterochromatization in parahaploid male mealybugs: involvement of a heterochromatin-associated protein. Development 128: 3809-3817 [Abstract] [Full Text]  
  • Shareef, M. M., King, C., Damaj, M., Badagu, R., Huang, D. W., Kellum, R. (2001). Drosophila Heterochromatin Protein 1 (HP1)/Origin Recognition Complex (ORC) Protein Is Associated with HP1 and ORC and Functions in Heterochromatin-induced Silencing. Mol. Biol. Cell 12: 1671-1685 [Abstract] [Full Text]  
  • Smothers, J. F., Henikoff, S. (2001). The Hinge and Chromo Shadow Domain Impart Distinct Targeting of HP1-Like Proteins. Mol. Cell. Biol. 21: 2555-2569 [Abstract] [Full Text]  
  • Kuhfittig, S., Szabad, J., Schotta, G., Hoffmann, J., Máthé, E., Reuter, G. (2001). pitkinD, a Novel Gain-of-Function Enhancer of Position-Effect Variegation, Affects Chromatin Regulation During Oogenesis and Early Embryogenesis in Drosophila. Genetics 157: 1227-1244 [Abstract] [Full Text]  
  • Krauss, V., Reuter, G. (2000). Two Genes Become One: The Genes Encoding Heterochromatin Protein SU(VAR)3-9 and Translation Initiation Factor Subunit eIF-2{gamma} Are Joined to a Dicistronic Unit in Holometabolic Insects. Genetics 156: 1157-1167 [Abstract] [Full Text]  
  • Lechner, M. S., Begg, G. E., Speicher, D. W., Rauscher, F. J. III (2000). Molecular Determinants for Targeting Heterochromatin Protein 1-Mediated Gene Silencing: Direct Chromoshadow Domain-KAP-1 Corepressor Interaction Is Essential. Mol. Cell. Biol. 20: 6449-6465 [Abstract] [Full Text]  
  • Marin, L., Lehmann, M., Nouaud, D., Izaabel, H., Anxolabéhère, D., Ronsseray, S. (2000). P-Element Repression in Drosophila melanogaster by a Naturally Occurring Defective Telomeric P Copy. Genetics 155: 1841-1854 [Abstract] [Full Text]  
  • Kirschmann, D. A., Lininger, R. A., Gardner, L. M. G., Seftor, E. A., Odero, V. A., Ainsztein, A. M., Earnshaw, W. C., Wallrath, L. L., Hendrix, M. J. C. (2000). Down-Regulation of HP1Hs{{alpha}} Expression Is Associated with the Metastatic Phenotype in Breast Cancer. Cancer Res. 60: 3359-3363 [Abstract] [Full Text]  
  • Melcher, M., Schmid, M., Aagaard, L., Selenko, P., Laible, G., Jenuwein, T. (2000). Structure-Function Analysis of SUV39H1 Reveals a Dominant Role in Heterochromatin Organization, Chromosome Segregation, and Mitotic Progression. Mol. Cell. Biol. 20: 3728-3741 [Abstract] [Full Text]  
  • Vernì, F., Gandhi, R., Goldberg, M. L., Gatti, M. (2000). Genetic and Molecular Analysis of wings apart-like (wapl), a Gene Controlling Heterochromatin Organization in Drosophila melanogaster. Genetics 154: 1693-1710 [Abstract] [Full Text]  
  • van der Vlag, J., den Blaauwen, J. L., Sewalt, R. G. A. B., van Driel, R., Otte, A. P. (2000). Transcriptional Repression Mediated by Polycomb Group Proteins and Other Chromatin-associated Repressors Is Selectively Blocked by Insulators. J. Biol. Chem. 275: 697-704 [Abstract] [Full Text]  
  • Haraguchi, T, Koujin, T, Hayakawa, T, Kaneda, T, Tsutsumi, C, Imamoto, N, Akazawa, C, Sukegawa, J, Yoneda, Y, Hiraoka, Y (2000). Live fluorescence imaging reveals early recruitment of emerin, LBR, RanBP2, and Nup153 to reforming functional nuclear envelopes. J. Cell Sci. 113: 779-794 [Abstract]  
  • Taddei, A., Roche, D., Sibarita, J.-B., Turner, B. M., Almouzni, G. (1999). Duplication and Maintenance of Heterochromatin Domains. JCB 147: 1153-1166 [Abstract] [Full Text]  
  • Iizuka, M., Stillman, B. (1999). Histone Acetyltransferase HBO1 Interacts with the ORC1 Subunit of the Human Initiator Protein. J. Biol. Chem. 274: 23027-23034 [Abstract] [Full Text]  
  • Zorin, I. D., Gerasimova, T. I., Corces, V. G. (1999). The lawc Gene Is a New Member of the trithorax-Group That Affects the Function of the gypsy Insulator of Drosophila. Genetics 152: 1045-1055 [Abstract] [Full Text]  
  • Ryan, R. F., Schultz, D. C., Ayyanathan, K., Singh, P. B., Friedman, J. R., Fredericks, W. J., Rauscher, F. J. III (1999). KAP-1 Corepressor Protein Interacts and Colocalizes with Heterochromatic and Euchromatic HP1 Proteins: a Potential Role for Kruppel-Associated Box-Zinc Finger Proteins in Heterochromatin-Mediated Gene Silencing. Mol. Cell. Biol. 19: 4366-4378 [Abstract] [Full Text]  
  • Ingram, R., Charrier, B., Scollan, C., Meyer, P. (1999). Transgenic Tobacco Plants Expressing the Drosophila Polycomb (Pc) Chromodomain Show Developmental Alterations: Possible Role of Pc Chromodomain Proteins in Chromatin-Mediated Gene Regulation in Plants. Plant Cell 11: 1047-1060 [Abstract] [Full Text]  
  • Zhao, T., Eissenberg, J. C. (1999). Phosphorylation of Heterochromatin Protein 1 by Casein Kinase II Is Required for Efficient Heterochromatin Binding in Drosophila. J. Biol. Chem. 274: 15095-15100 [Abstract] [Full Text]  
  • Remboutsika, E, Lutz, Y, Gansmuller, A, Vonesch, J., Losson, R, Chambon, P (1999). The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin. J. Cell Sci. 112: 1671-1683 [Abstract]  
  • Roche, S. E., Rio, D. C. (1998). Trans-Silencing by P Elements Inserted in Subtelomeric Heterochromatin Involves the Drosophila Polycomb Group Gene, Enhancer of zeste. Genetics 149: 1839-1855 [Abstract] [Full Text]  
  • Ronsseray, S., Marin, L., Lehmann, M., Anxolabehere, D. (1998). Repression of Hybrid Dysgenesis in Drosophila melanogaster by Combinations of Telomeric P-Element Reporters and Naturally Occurring P Elements. Genetics 149: 1857-1866 [Abstract] [Full Text]  
  • Huang, D. W., Fanti, L., Pak, D. T.S., Botchan, M. R., Pimpinelli, S., Kellum, R. (1998). Distinct Cytoplasmic and Nuclear Fractions of Drosophila Heterochromatin Protein 1: Their Phosphorylation Levels and Associations with Origin Recognition Complex Proteins. JCB 142: 307-318 [Abstract] [Full Text]  
  • Lamond, A. I., Earnshaw, W. C. (1998). Structure and Function in the Nucleus. Science 280: 547-553 [Abstract] [Full Text]  
  • Buchenau, P., Hodgson, J., Strutt, H., Arndt-Jovin, D. J. (1998). The Distribution of Polycomb-Group Proteins During Cell Division and Development in Drosophila Embryos: Impact on Models for Silencing. JCB 141: 469-481 [Abstract] [Full Text]  
  • Bel, S, Core, N, Djabali, M, Kieboom, K, Van der Lugt, N, Alkema, M., Van Lohuizen, M (1998). Genetic interactions and dosage effects of Polycomb group genes in mice. Development 125: 3543-3551 [Abstract]  
  • Lahn, B. T., Page, D. C. (1997). Functional Coherence of the Human Y Chromosome. Science 278: 675-680 [Abstract] [Full Text]  
  • Ye, Q., Callebaut, I., Pezhman, A., Courvalin, J.-C., Worman, H. J. (1997). Domain-specific Interactions of Human HP1-type Chromodomain Proteins and Inner Nuclear Membrane Protein LBR. J. Biol. Chem. 272: 14983-14989 [Abstract] [Full Text]  
  • Frankel, S, Sigel, E., Craig, C, Elgin, S., Mooseker, M., Artavanis-Tsakonas, S (1997). An actin-related protein in Drosophila colocalizes with heterochromatin protein 1 in pericentric heterochromatin. J. Cell Sci. 110: 1999-2012 [Abstract]  
  • Ye, Q., Worman, H. J. (1996). Interaction between an Integral Protein of the Nuclear Envelope Inner Membrane and Human Chromodomain Proteins Homologous to Drosophila HP1. J. Biol. Chem. 271: 14653-14656 [Abstract] [Full Text]  
  • Nicol, L, Jeppesen, P (1996). Chromatin organization in the homogeneously staining regions of a methotrexate-resistant mouse cell line: interspersion of inactive and active chromatin domains distinguished by acetylation of histone H4. J. Cell Sci. 109: 2221-2228 [Abstract]  
  • Pluta, A. F., Mackay, A. M., Ainsztein, A. M., Goldberg, I. G., Earnshaw, W. C. (1995). The Centromere: Hub of Chromosomal Activities. Science 270: 1591-1594 [Abstract]  
  • Trofatter, J A, Long, K R, Murrell, J R, Stotler, C J, Gusella, J F, Buckler, A J (1995). An expression-independent catalog of genes from human chromosome 22.. Genome Res 5: 214-224 [Abstract]  
  • Muller, J, Gaunt, S, Lawrence, P. (1995). Function of the Polycomb protein is conserved in mice and flies. Development 121: 2847-2852 [Abstract]  
  • Kellum, R, Raff, J., Alberts, B. (1995). Heterochromatin protein 1 distribution during development and during the cell cycle in Drosophila embryos. J. Cell Sci. 108: 1407-1418 [Abstract]  
  • Kellum, R, Alberts, B. (1995). Heterochromatin protein 1 is required for correct chromosome segregation in Drosophila embryos. J. Cell Sci. 108: 1419-1431 [Abstract]  
  • Singh, P. (1994). Molecular mechanisms of cellular determination: their relation to chromatin structure and parental imprinting. J. Cell Sci. 107: 2653-2668  
  • Saunders, W., Chue, C, Goebl, M, Craig, C, Clark, R., Powers, J., Eissenberg, J., Elgin, S., Rothfield, N., Earnshaw, W. (1993). Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity. J. Cell Sci. 104: 573-582 [Abstract]  
  • Thompson, J.S., Hecht, A., Grunstein, M. (1993). Histones and the Regulation of Heterochromatin in Yeast. Cold Spring Harb Symp Quant Biol 58: 247-256 [Abstract]  
  • Messmer, S, Franke, A, Paro, R (1992). Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster.. Genes Dev. 6: 1241-1254 [Abstract]  
  • Amero, S A, Elgin, S C, Beyer, A L (1991). A unique zinc finger protein is associated preferentially with active ecdysone-responsive loci in Drosophila.. Genes Dev. 5: 188-200 [Abstract]  
  • Pfeifer, G P, Tanguay, R L, Steigerwald, S D, Riggs, A D (1990). In vivo footprint and methylation analysis by PCR-aided genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1.. Genes Dev. 4: 1277-1287 [Abstract]  
  • Zhao, T., Heyduk, T., Allis, C. D., Eissenberg, J. C. (2000). Heterochromatin Protein 1 Binds to Nucleosomes and DNA in Vitro. J. Biol. Chem. 275: 28332-28338 [Abstract] [Full Text]  
  • Kourmouli, N., Dialynas, G., Petraki, C., Pyrpasopoulou, A., Singh, P. B., Georgatos, S. D., Theodoropoulos, P. A. (2001). Binding of Heterochromatin Protein 1 to the Nuclear Envelope Is Regulated by a Soluble Form of Tubulin. J. Biol. Chem. 276: 13007-13014 [Abstract] [Full Text]  
  • Song, K., Jung, Y., Jung, D., Lee, I. (2001). Human Ku70 Interacts with Heterochromatin Protein 1alpha. J. Biol. Chem. 276: 8321-8327 [Abstract] [Full Text]  
  • Zhao, T., Heyduk, T., Eissenberg, J. C. (2001). Phosphorylation Site Mutations in Heterochromatin Protein 1 (HP1) Reduce or Eliminate Silencing Activity. J. Biol. Chem. 276: 9512-9518 [Abstract] [Full Text]  
  • Hwang, K.-K., Eissenberg, J. C., Worman, H. J. (2001). Transcriptional repression of euchromatic genes by Drosophila heterochromatin protein 1 and histone modifiers. Proc. Natl. Acad. Sci. USA 98: 11423-11427 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»