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Mol Cell Biol. 1986 February; 6(2): 494-501

A position effect on the expression of a tRNA gene mediated by the SIR genes in Saccharomyces cerevisiae.

ABSTRACT

The SIR genes of Saccharomyces cerevisiae are responsible for the position-dependent regulation of the a and alpha mating-type genes. Previous work by others has shown that the products of the SIR genes prevent the accumulation of stable transcripts of the a and alpha genes at HML and HMR. Results of this study establish that this regulation is a region-specific effect rather than a gene-specific effect since expression of a tRNA gene placed at HMR is repressed by the products of the SIR genes.

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