This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Marlor, R L Articles by Corces, V G Search for Related Content PubMed PubMed Citation Articles by Marlor, R L Articles by Corces, V G

 Previous Article  |  Next Article 

Mol Cell Biol. 1986 April; 6(4): 1129-1134

The Drosophila melanogaster gypsy transposable element encodes putative gene products homologous to retroviral proteins.

ABSTRACT

We determined the complete nucleotide sequence of the gypsy element present at the forked locus of Drosophila melanogaster in the f1 allele. The gypsy element shares more homology with vertebrate retroviruses than with the copia element of D. melanogaster or the Ty element of Saccharomyces cerevisiae, both in overall organization and at the DNA sequence level. This transposable element is 7,469 base pairs long and encodes three putative protein products. The long terminal repeats are 482 nucleotides long and contain transcription initiation and termination signals; sequences homologous to the polypurine tract and tRNA primer binding site of retroviruses are located adjacent to the long terminal repeats. The central region of the element contains three different open reading frames. The second one encodes a putative protein which shows extensive amino acid homology to retroviral proteins, including gag-specific protease, reverse transcriptase, and DNA endonuclease.

This article has been cited by other articles:

• Terzian, C., Henry, M., Meyerhans, A., Wain-Hobson, S., Vartanian, J.-P. (2007). Induction of Mutations in Drosophila melanogaster gypsy Retroelements by Modulation of Intracellular Deoxynucleoside Triphosphate Pools In Vivo. J. Virol. 81: 4900-4903 [Abstract] [Full Text]  
• Mevel-Ninio, M., Pelisson, A., Kinder, J., Campos, A. R., Bucheton, A. (2007). The flamenco Locus Controls the gypsy and ZAM Retroviruses and Is Required for Drosophila Oogenesis. Genetics 175: 1615-1624 [Abstract] [Full Text]  
• Gabus, C., Ivanyi-Nagy, R., Depollier, J., Bucheton, A., Pelisson, A., Darlix, J.-L. (2006). Characterization of a nucleocapsid-like region and of two distinct primer tRNALys,2 binding sites in the endogenous retrovirus Gypsy. Nucleic Acids Res 34: 5764-5777 [Abstract] [Full Text]  
• Kravchenko, E., Savitskaya, E., Kravchuk, O., Parshikov, A., Georgiev, P., Savitsky, M. (2005). Pairing between gypsy Insulators Facilitates the Enhancer Action in trans throughout the Drosophila Genome. Mol. Cell. Biol. 25: 9283-9291 [Abstract] [Full Text]  
• Golovnin, A., Melnick, E., Mazur, A., Georgiev, P. (2005). Drosophila Su(Hw) Insulator Can Stimulate Transcription of a Weakened yellow Promoter Over a Distance. Genetics 170: 1133-1142 [Abstract] [Full Text]  
• RONFORT, C., DE BREYNE, S., SANDRIN, V., DARLIX, J.-L., OHLMANN, T. (2004). Characterization of two distinct RNA domains that regulate translation of the Drosophila gypsy retroelement. RNA 10: 504-515 [Abstract] [Full Text]  
• Sarot, E., Payen-Groschene, G., Bucheton, A., Pelisson, A. (2004). Evidence for a piwi-Dependent RNA Silencing of the gypsy Endogenous Retrovirus by the Drosophila melanogaster flamenco Gene. Genetics 166: 1313-1321 [Abstract] [Full Text]  
• Kuhn, E. J., Hart, C. M., Geyer, P. K. (2004). Studies of the Role of the Drosophila scs and scs' Insulators in Defining Boundaries of a Chromosome Puff. Mol. Cell. Biol. 24: 1470-1480 [Abstract] [Full Text]  
• Parnell, T. J., Viering, M. M., Skjesol, A., Helou, C., Kuhn, E. J., Geyer, P. K. (2003). An endogenous Suppressor of Hairy-wing insulator separates regulatory domains in Drosophila. Proc. Natl. Acad. Sci. USA 100: 13436-13441 [Abstract] [Full Text]  
• Savitsky, M., Kahn, T., Pomerantseva, E., Georgiev, P. (2003). Transvection at the End of the Truncated Chromosome in Drosophila melanogaster. Genetics 163: 1375-1387 [Abstract] [Full Text]  
• Melnikova, L., Gause, M., Georgiev, P. (2002). The gypsy Insulators Flanking yellow Enhancers Do Not Form a Separate Transcriptional Domain in Drosophila melanogaster: The Enhancers Can Activate an Isolated yellow Promoter. Genetics 160: 1549-1560 [Abstract] [Full Text]  
• Leblanc, P., Desset, S., Giorgi, F., Taddei, A. R., Fausto, A. M., Mazzini, M., Dastugue, B., Vaury, C. (2000). Life Cycle of an Endogenous Retrovirus, ZAM, in Drosophila melanogaster. J. Virol. 74: 10658-10669 [Abstract] [Full Text]  
• Terzian, C., Ferraz, C., Demaille, J., Bucheton, A. (2000). Evolution of the Gypsy Endogenous Retrovirus in the Drosophila melanogaster Subgroup. Mol Biol Evol 17: 908-914 [Abstract] [Full Text]  
• Scott, K. C., Taubman, A. D., Geyer, P. K. (1999). Enhancer Blocking by the Drosophila gypsy Insulator Depends Upon Insulator Anatomy and Enhancer Strength. Genetics 153: 787-798 [Abstract] [Full Text]  
• Hajek, K. L., Friesen, P. D. (1998). Proteolytic Processing and Assembly of gag and gag-pol Proteins of TED, a Baculovirus-Associated Retrotransposon of the Gypsy Family. J. Virol. 72: 8718-8724 [Abstract] [Full Text]  
• Gause, M., Hovhannisyan, H., Kan, T., Kuhfittig, S., Mogila, V., Georgiev, P. (1998). hobo Induced Rearrangements in the yellow Locus Influence the Insulation Effect of the gypsy su(Hw)-Binding Region in Drosophila melanogaster. Genetics 149: 1393-1405 [Abstract] [Full Text]  
• Laten, H. M., Majumdar, A., Gaucher, E. A. (1998). SIRE-1, a copia/Ty1-like retroelement from soybean, encodes a retroviral envelope-like protein. Proc. Natl. Acad. Sci. USA 95: 6897-6902 [Abstract] [Full Text]  
• Nabirochkin, S., Ossokina, M., Heidmann, T. (1998). A Nuclear Matrix/Scaffold Attachment Region Co-localizes with the Gypsy Retrotransposon Insulator Sequence. J. Biol. Chem. 273: 2473-2479 [Abstract] [Full Text]  
• Teysset, L., Burns, J. C., Shike, H., Sullivan, B. L., Bucheton, A., Terzian, C. (1998). A Moloney Murine Leukemia Virus-Based Retroviral Vector Pseudotyped by the Insect Retroviral gypsy Envelope Can Infect Drosophila Cells. J. Virol. 72: 853-856 [Abstract] [Full Text]  
• (1998). Polycomb Group Repression Is Blocked by the Drosophila suppressor of Hairy-wing [su(Hw)] Insulator. Genetics 148: 331-340  
• Tsai, S.-F., Jang, C.-C., Prikhod'ko, G. G., Bessarab, D. A., Tang, C.-Y., Pflugfelder, G. O., Sun, Y. H. (1997). Gypsy retrotransposon as a tool for the in vivo analysis of the regulatory region of the optomotor-blind gene in Drosophila. Proc. Natl. Acad. Sci. USA 94: 3837-3831 [Abstract] [Full Text]  
• Song, S., Kurkulos, M, Boeke, J., Corces, V. (1997). Infection of the germ line by retroviral particles produced in the follicle cells: a possible mechanism for the mobilization of the gypsy retroelement of Drosophila. Development 124: 2789-2798 [Abstract]  
• Roseman, R., Swan, J., Geyer, P. (1995). A Drosophila insulator protein facilitates dosage compensation of the X chromosome min-white gene located at autosomal insertion sites. Development 121: 3573-3582 [Abstract]  
• Song, S U, Gerasimova, T, Kurkulos, M, Boeke, J D, Corces, V G (1994). An env-like protein encoded by a Drosophila retroelement: evidence that gypsy is an infectious retrovirus.. Genes Dev. 8: 2046-2057 [Abstract]  
• Geyer, P K, Corces, V G (1992). DNA position-specific repression of transcription by a Drosophila zinc finger protein.. Genes Dev. 6: 1865-1873 [Abstract]  
• Spana, C, Corces, V G (1990). DNA bending is a determinant of binding specificity for a Drosophila zinc finger protein.. Genes Dev. 4: 1505-1515 [Abstract]  
• Dorsett, D, Viglianti, G A, Rutledge, B J, Meselson, M (1989). Alteration of hsp82 gene expression by the gypsy transposon and suppressor genes in Drosophila melanogaster.. Genes Dev. 3: 454-468 [Abstract]  
• Spana, C, Harrison, D A, Corces, V G (1988). The Drosophila melanogaster suppressor of Hairy-wing protein binds to specific sequences of the gypsy retrotransposon.. Genes Dev. 2: 1414-1423 [Abstract]