This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yamanashi, Y Articles by Toyoshima, K Search for Related Content PubMed PubMed Citation Articles by Yamanashi, Y Articles by Toyoshima, K

 Previous Article  |  Next Article 

Mol Cell Biol. 1987 January; 7(1): 237-243

The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck.

ABSTRACT

With v-yes DNA as the probe, a human cDNA library made from placental RNA was screened under relaxed conditions, and DNA clones derived from a novel genetic locus, termed lyn, were obtained. Nucleotide sequencing revealed that lyn could encode a novel tyrosine kinase that was very similar to mouse T-lymphocyte-specific tyrosine kinase p56lck and the v-yes protein as well as to the gene products of v-fgr and v-src. Northern hybridization analysis revealed that a 3.2-kilobase lyn mRNA was expressed in a variety of tissues of the human fetus. The pattern of lyn mRNA expression was different from those of related genes, such as yes and syn. Hybridization analysis of DNA from sorted chromosomes showed that the lyn gene is located on human chromosome 8 q13-qter.

This article has been cited by other articles:

• Huang, F., Reeves, K., Han, X., Fairchild, C., Platero, S., Wong, T. W., Lee, F., Shaw, P., Clark, E. (2007). Identification of Candidate Molecular Markers Predicting Sensitivity in Solid Tumors to Dasatinib: Rationale for Patient Selection. Cancer Res. 67: 2226-2238 [Abstract] [Full Text]  
• Kasahara, K., Nakayama, Y., Nakazato, Y., Ikeda, K., Kuga, T., Yamaguchi, N. (2007). Src Signaling Regulates Completion of Abscission in Cytokinesis through ERK/MAPK Activation at the Midbody. J. Biol. Chem. 282: 5327-5339 [Abstract] [Full Text]  
• Bredel, M., Bredel, C., Juric, D., Harsh, G. R., Vogel, H., Recht, L. D., Sikic, B. I. (2005). Functional Network Analysis Reveals Extended Gliomagenesis Pathway Maps and Three Novel MYC-Interacting Genes in Human Gliomas. Cancer Res. 65: 8679-8689 [Abstract] [Full Text]  
• Kasahara, K., Nakayama, Y., Ikeda, K., Fukushima, Y., Matsuda, D., Horimoto, S., Yamaguchi, N. (2004). Trafficking of Lyn through the Golgi caveolin involves the charged residues on {alpha}E and {alpha}I helices in the kinase domain. J. Cell Biol. 165: 641-652 [Abstract] [Full Text]  
• Mielenz, D., Ruschel, A., Vettermann, C., Jack, H.-M. (2003). Immunoglobulin {micro} Heavy Chains Do Not Mediate Tyrosine Phosphorylation of Ig{alpha} from the ER-cis-Golgi. J. Immunol. 171: 3091-3101 [Abstract] [Full Text]  
• O'Laughlin-Bunner, B., Radosevic, N., Taylor, M. L., Shivakrupa, , DeBerry, C., Metcalfe, D. D., Zhou, M., Lowell, C., Linnekin, D. (2001). Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells. Blood 98: 343-350 [Abstract] [Full Text]  
• Gottlieb, K. A., Villarreal, L. P. (2001). Natural Biology of Polyomavirus Middle T Antigen. Microbiol. Mol. Biol. Rev. 65: 288-318 [Abstract] [Full Text]  
• Tilbrook, P. A., Palmer, G. A., Bittorf, T., McCarthy, D. J., Wright, M. J., Sarna, M. K., Linnekin, D., Cull, V. S., Williams, J. H., Ingley, E., Schneider-Mergener, J., Krystal, G., Klinken, S. P. (2001). Maturation of Erythroid Cells and Erythroleukemia Development Are Affected by the Kinase Activity of Lyn. Cancer Res. 61: 2453-2458 [Abstract] [Full Text]  
• Yoshida, K., Weichselbaum, R., Kharbanda, S., Kufe, D. (2000). Role for Lyn Tyrosine Kinase as a Regulator of Stress-Activated Protein Kinase Activity in Response to DNA Damage. Mol. Cell. Biol. 20: 5370-5380 [Abstract] [Full Text]  
• Ingley, E., Sarna, M. K., Beaumont, J. G., Tilbrook, P. A., Tsai, S., Takemoto, Y., Williams, J. H., Klinken, S. P. (2000). HS1 Interacts with Lyn and Is Critical for Erythropoietin-induced Differentiation of Erythroid Cells. J. Biol. Chem. 275: 7887-7893 [Abstract] [Full Text]  
• Corey, S. J., Anderson, S. M. (1999). Src-Related Protein Tyrosine Kinases in Hematopoiesis. Blood 93: 1-14 [Full Text]  
• Chin, H., Arai, A., Wakao, H., Kamiyama, R., Miyasaka, N., Miura, O. (1998). Lyn Physically Associates With the Erythropoietin Receptor and May Play a Role in Activation of the Stat5 Pathway. Blood 91: 3734-3745 [Abstract] [Full Text]  
• Hirao, A., Huang, X.-L., Suda, T., Yamaguchi, N. (1998). Overexpression of C-terminal Src Kinase Homologous Kinase Suppresses Activation of Lyn Tyrosine Kinase Required for VLA5-mediated Dami Cell Spreading. J. Biol. Chem. 273: 10004-10010 [Abstract] [Full Text]  
• Vonakis, B. M., Chen, H., Haleem-Smith, H., Metzger, H. (1997). The Unique Domain as the Site on Lyn Kinase for Its Constitutive Association with the High Affinity Receptor for IgE. J. Biol. Chem. 272: 24072-24080 [Abstract] [Full Text]  
• DeAizpurua, H. J., Cram, D. S., Naselli, G., Devereux, L., Dorow, D. S. (1997). Expression of Mixed Lineage Kinase-1 in Pancreatic beta -Cell Lines at Different Stages of Maturation and during Embryonic Pancreas Development. J. Biol. Chem. 272: 16364-16373 [Abstract] [Full Text]  
• Katagiri, K., Yokoyama, K. K., Yamamoto, T., Omura, S., Irie, S., Katagiri, T. (1996). Lyn and Fgr Protein-tyrosine Kinases Prevent Apoptosis during Retinoic Acid-induced Granulocytic Differentiation of HL-60 Cells. J. Biol. Chem. 271: 11557-11562 [Abstract] [Full Text]  
• Brumell, J. H., Burkhardt, A. L., Bolen, J. B., Grinstein, S. (1996). Endogenous Reactive Oxygen Intermediates Activate Tyrosine Kinases in Human Neutrophils. J. Biol. Chem. 271: 1455-1461 [Abstract] [Full Text]  
• Koch, C., Anderson, D, Moran, M., Ellis, C, Pawson, T (1991). SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science 252: 668-674 [Abstract]  
• Yamanashi, Y, Kakiuchi, T, Mizuguchi, J, Yamamoto, T, Toyoshima, K (1991). Association of B cell antigen receptor with protein tyrosine kinase Lyn. Science 251: 192-194 [Abstract]  
• Hirai, H, Varmus, H E (1990). SH2 mutants of c-src that are host dependent for transformation are trans-dominant inhibitors of mouse cell transformation by activated c-src.. Genes Dev. 4: 2342-2352 [Abstract]  
• Hanks, S., Quinn, A., Hunter, T (1988). The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241: 42-52 [Abstract]  
• Vonakis, B. M., Haleem-Smith, H., Benjamin, P., Metzger, H. (2001). Interaction between the Unphosphorylated Receptor with High Affinity for IgE and Lyn Kinase. J. Biol. Chem. 276: 1041-1050 [Abstract] [Full Text]  
• Gaul, B. S., Harrison, M. L., Geahlen, R. L., Burton, R. A., Post, C. B. (2000). Substrate Recognition by the Lyn Protein-tyrosine Kinase. NMR STRUCTURE OF THE IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIF SIGNALING REGION OF THE B CELL ANTIGEN RECEPTOR. J. Biol. Chem. 275: 16174-16182 [Abstract] [Full Text]