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Mol Cell Biol. 1987 January; 7(1): 535-540

The genome of Shope fibroma virus, a tumorigenic poxvirus, contains a growth factor gene with sequence similarity to those encoding epidermal growth factor and transforming growth factor alpha.

W Chang, C Upton, S L Hu, A F Purchio and G McFadden

ABSTRACT

Degenerate oligonucleotide probes corresponding to a highly conserved region common to epidermal growth factor, transforming growth factor alpha, and vaccinia growth factor were used to identify a novel growth factor gene in the Shope fibroma virus genome. Sequence analysis indicates that the Shope fibroma growth factor is a distinct new member of this family of growth factors.


Mol Cell Biol. 1987 January; 7(1): 535-540




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