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Mol Cell Biol. 1987 November; 7(11): 4130-4133

A complex translocation at the murine kappa light-chain locus.

M A Shapiro and M Weigert

Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.

ABSTRACT

We have previously reported that a segment of DNA from a murine plasmacytoma comprises DNA from three chromosomes, the immunoglobulin kappa light-chain locus on chromosome 6, the S mu locus on chromosome 12, and a region on chromosome 15. We now report that the reciprocal product contains DNA from only the kappa locus and chromosome 15 and not from S mu. We conclude that a complex series of events, including both a transposition of DNA and a translocation between chromosomes, generated these imperfect reciprocal products.

Mol Cell Biol. 1987 November; 7(11): 4130-4133




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