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Mol Cell Biol. 1987 November; 7(11): 4134-4138

A human tRNA(iMet) gene produces multiple transcripts.

Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.

ABSTRACT

A third nonallelic locus of the human methionyl-tRNA multigene family (tRNA(iMet-3) was isolated. This gene, unlike two other tRNA(iMet) loci, lacks a remarkable run of T and C residues which functions as a termination of transcription signal. Instead, three tandem termination signals, each containing no more than four thymidylate residues, function as relatively inefficient termination signals. As a result, polymerase readthrough generates at least three transcripts in vitro. The efficiency of apparent termination varies significantly at these sites. All resulting transcripts appear to be processed in vitro.

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