This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Levy, J B
Right arrow Articles by Brugge, J S
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Levy, J B
Right arrow Articles by Brugge, J S

 Previous Article  |  Next Article 

Mol Cell Biol. 1987 November; 7(11): 4142-4145

The structurally distinct form of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA.

J B Levy, T Dorai, L H Wang and J S Brugge

Department of Microbiology, State University of New York, Stony Brook 11794.

ABSTRACT

A cellular src (c-src) cDNA clone was isolated from a chicken embryonic brain cDNA library and characterized by DNA sequence analysis. Comparison with the published sequence of a chicken genomic c-src clone indicated that the brain cDNA clone contained an 18-base-pair insertion located between exons 3 and 4 of the c-src gene. The six amino acids encoded by the insertion caused an alteration in the electrophoretic mobility of the c-src gene product similar to that of the structurally distinct form of the src protein detected in neuronal cultures.

Mol Cell Biol. 1987 November; 7(11): 4142-4145




This article has been cited by other articles:

  • Reynolds, C. H., Garwood, C. J., Wray, S., Price, C., Kellie, S., Perera, T., Zvelebil, M., Yang, A., Sheppard, P. W., Varndell, I. M., Hanger, D. P., Anderton, B. H. (2008). Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase C{gamma}1, Grb2, and Src Family Kinases. J. Biol. Chem. 283: 18177-18186 [Abstract] [Full Text]  
  • Liang, Y., Roizman, B. (2006). State and role of SRC family kinases in replication of herpes simplex virus 1.. J. Virol. 80: 3349-3359 [Abstract] [Full Text]  
  • Le Sommer, C., Lesimple, M., Mereau, A., Menoret, S., Allo, M.-R., Hardy, S. (2005). PTB Regulates the Processing of a 3'-Terminal Exon by Repressing both Splicing and Polyadenylation. Mol. Cell. Biol. 25: 9595-9607 [Abstract] [Full Text]  
  • Hall, M. P., Huang, S., Black, D. L. (2004). Differentiation-induced Colocalization of the KH-type Splicing Regulatory Protein with Polypyrimidine Tract Binding Protein and the c-src Pre-mRNA. Mol. Biol. Cell 15: 774-786 [Abstract] [Full Text]  
  • Mukherjee, A., Arnaud, L., Cooper, J. A. (2003). Lipid-dependent Recruitment of Neuronal Src to Lipid Rafts in the Brain. J. Biol. Chem. 278: 40806-40814 [Abstract] [Full Text]  
  • Rooke, N., Markovtsov, V., Cagavi, E., Black, D. L. (2003). Roles for SR Proteins and hnRNP A1 in the Regulation of c-src Exon N1. Mol. Cell. Biol. 23: 1874-1884 [Abstract] [Full Text]  
  • Korade-Mirnics, Z., Corey, S. J. (2000). Src kinase-mediated signaling in leukocytes. J. Leukoc. Biol. 68: 603-613 [Abstract] [Full Text]  
  • Müller, J., Cacace, A. M., Lyons, W. E., McGill, C. B., Morrison, D. K. (2000). Identification of B-KSR1, a Novel Brain-Specific Isoform of KSR1 That Functions in Neuronal Signaling. Mol. Cell. Biol. 20: 5529-5539 [Abstract] [Full Text]  
  • Chou, M.-Y., Rooke, N., Turck, C. W., Black, D. L. (1999). hnRNP H Is a Component of a Splicing Enhancer Complex That Activates a c-src Alternative Exon in Neuronal Cells. Mol. Cell. Biol. 19: 69-77 [Abstract] [Full Text]  
  • Corey, S. J., Anderson, S. M. (1999). Src-Related Protein Tyrosine Kinases in Hematopoiesis. Blood 93: 1-14 [Full Text]  
  • Palm, K., Belluardo, N., Metsis, M., Timmusk, T o. (1998). Neuronal Expression of Zinc Finger Transcription Factor REST/NRSF/XBR Gene. J. Neurosci. 18: 1280-1296 [Abstract] [Full Text]  
  • Min, H, Turck, C W, Nikolic, J M, Black, D L (1997). A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer.. Genes Dev. 11: 1023-1036 [Abstract]  
  • Min, H, Chan, R C, Black, D L (1995). The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event.. Genes Dev. 9: 2659-2671 [Abstract]  
  • Grant, S G, Karl, K A, Kiebler, M A, Kandel, E R (1995). Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice.. Genes Dev. 9: 1909-1921 [Abstract]  
  • Rowley, R. B., Bolen, J. B., Fargnoli, J. (1995). Molecular Cloning of Rodent p72[IMAGE]. J. Biol. Chem. 270: 12659-12664 [Abstract] [Full Text]  
  • Yu, H, Rosen, M., Shin, T., Seidel-Dugan, C, Brugge, J., Schreiber, S. (1992). Solution structure of the SH3 domain of Src and identification of its ligand-binding site. Science 258: 1665-1668 [Abstract]  
  • Chen, M. S., Burgess, C. C., Vallee, R. B., Wadsworth, S. C. (1992). Developmental stage- and tissue-specific expression of shibire, a Drosophila gene involved in endocytosis. J. Cell Sci. 103: 619-628 [Abstract]  
  • Mumberg, D, Lucibello, F C, Schuermann, M, Muller, R (1991). Alternative splicing of fosB transcripts results in differentially expressed mRNAs encoding functionally antagonistic proteins.. Genes Dev. 5: 1212-1223 [Abstract]  
  • Black, D L (1991). Does steric interference between splice sites block the splicing of a short c-src neuron-specific exon in non-neuronal cells?. Genes Dev. 5: 389-402 [Abstract]  
  • Vincent, W S, Gregory, R J, Wadsworth, S C (1989). Embryonic expression of a Drosophila src gene: alternate forms of the protein are expressed in segmental stripes and in the nervous system.. Genes Dev. 3: 334-347 [Abstract]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»