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Mol Cell Biol. 1987 December; 7(12): 4564-4567

Plasminogen activator inhibitor 2: regulation of gene transcription during phorbol ester-mediated differentiation of U-937 human histiocytic lymphoma cells.

W D Schleuning, R L Medcalf, C Hession, R Rothenbühler, A Shaw and E K Kruithof

Department of Medicine, University Hospital Center, CHUV, Lausanne, Switzerland.

ABSTRACT

We have isolated and sequenced two cDNA clones coding for plasminogen activator inhibitor 2 (PAI-2). The cDNA was used to study the regulation of PAI-2 gene transcription by the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate in the human histiocytic lymphoma cell line U-937. The tumor promoter caused a transient, 50-fold increase of PAI-2 gene transcription.

Mol Cell Biol. 1987 December; 7(12): 4564-4567




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