This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gegonne, A Articles by Stehelin, D Search for Related Content PubMed PubMed Citation Articles by Gegonne, A Articles by Stehelin, D

 Previous Article  |  Next Article 

Mol Cell Biol. 1987 February; 7(2): 806-812

Multiple domains for the chicken cellular sequences homologous to the v-ets oncogene of the E26 retrovirus.

ABSTRACT

We have investigated the structure of chicken genomic DNA homologous to v-ets, the second cell-derived oncogene of avian retrovirus E26. We isolated a c-ets locus spanning ca. 30.0 kilobase pairs (kbp) in the chicken genome with homologies to 1,202 nucleotides (nt) of v-ets (total length, 1,508 nt) distributed in six clusters along 18.0 kbp of the cloned DNA. The 5'-distal part of v-ets (224 nt) was homologous to chicken cellular sequences contained upstream within a single 16.0-kbp EcoRI fragment as two typical exons but not found transcribed into the major 7.5-kb c-ets (or 4.0-kb c-myb) RNA species. Between these two v-ets-related cellular sequences we found ca 40.0 kbp of v-ets-unrelated DNA. Finally, the most 3' region of homology to v-ets in the cloned DNA was shown to consist of a truncated exon lacking the nucleotides coding for the 16 carboxy-terminal amino acids of the viral protein but colinear to one of the two human c-ets loci, c-ets-2.

This article has been cited by other articles:

• Gunther, C V, Nye, J A, Bryner, R S, Graves, B J (1990). Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus.. Genes Dev. 4: 667-679 [Abstract]  
• Boulukos, K E, Pognonec, P, Sariban, E, Bailly, M, Lagrou, C, Ghysdael, J (1990). Rapid and transient expression of Ets2 in mature macrophages following stimulation with cMGF, LPS, and PKC activators.. Genes Dev. 4: 401-409 [Abstract]