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Mol Cell Biol. 1987 February; 7(2): 932-935

Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation.

M J Sawey, A T Hood, F J Burns and S J Garte

ABSTRACT

An activated K-ras oncogene was detected by transfection in NIH 3T3 cells and by Southern blot analysis in 6 of 12 rat skin tumors induced by ionizing radiation. The DNA from 10 of the 12 tumors also showed c-myc gene amplification and restriction polymorphisms. Evidence for tissue specificity was observed in patterns of oncogene activation, with each of three clear cell carcinomas exhibiting activation of both c-myc and K-ras oncogenes.

Mol Cell Biol. 1987 February; 7(2): 932-935




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