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Mol Cell Biol. 1987 May; 7(5): 1602-1611

Eucaryotic RNA polymerase conditional mutant that rapidly ceases mRNA synthesis.

ABSTRACT

We have isolated a yeast conditional mutant which rapidly ceases synthesis of mRNA when subjected to the nonpermissive temperature. This mutant (rpb1-1) was constructed by replacing the wild-type chromosomal copy of the gene encoding the largest subunit of RNA polymerase II with one mutagenized in vitro. The rapid cessation of mRNA synthesis in vivo and the lack of RNA polymerase II activity in crude extracts indicate that the mutant possesses a functionally defective, rather than an assembly-defective, RNA polymerase II. The shutdown in mRNA synthesis in the rpb1-1 mutant has pleiotropic effects on the synthesis of other RNAs and on the heat shock response. This mutant provides direct evidence that the RPB1 protein has a functional role in mRNA synthesis.

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• Nair, D., Kim, Y., Myers, L. C. (2005). Mediator and TFIIH Govern Carboxyl-terminal Domain-dependent Transcription in Yeast Extracts. J. Biol. Chem. 280: 33739-33748 [Abstract] [Full Text]  
• Duttagupta, R., Tian, B., Wilusz, C. J., Khounh, D. T., Soteropoulos, P., Ouyang, M., Dougherty, J. P., Peltz, S. W. (2005). Global Analysis of Pub1p Targets Reveals a Coordinate Control of Gene Expression through Modulation of Binding and Stability. Mol. Cell. Biol. 25: 5499-5513 [Abstract] [Full Text]  
• Xu, C., Henry, M. F. (2004). Nuclear Export of hnRNP Hrp1p and Nuclear Export of hnRNP Npl3p Are Linked and Influenced by the Methylation State of Npl3p. Mol. Cell. Biol. 24: 10742-10756 [Abstract] [Full Text]  
• Schneider, B. L., Zhang, J., Markwardt, J., Tokiwa, G., Volpe, T., Honey, S., Futcher, B. (2004). Growth Rate and Cell Size Modulate the Synthesis of, and Requirement for, G1-Phase Cyclins at Start. Mol. Cell. Biol. 24: 10802-10813 [Abstract] [Full Text]  
• Grigull, J., Mnaimneh, S., Pootoolal, J., Robinson, M. D., Hughes, T. R. (2004). Genome-Wide Analysis of mRNA Stability Using Transcription Inhibitors and Microarrays Reveals Posttranscriptional Control of Ribosome Biogenesis Factors. Mol. Cell. Biol. 24: 5534-5547 [Abstract] [Full Text]  
• Fath, S., Kobor, M. S., Philippi, A., Greenblatt, J., Tschochner, H. (2004). Dephosphorylation of RNA Polymerase I by Fcp1p Is Required for Efficient rRNA Synthesis. J. Biol. Chem. 279: 25251-25259 [Abstract] [Full Text]  
• Plant, E. P., Wang, P., Jacobs, J. L., Dinman, J. D. (2004). A programmed -1 ribosomal frameshift signal can function as a cis-acting mRNA destabilizing element. Nucleic Acids Res 32: 784-790 [Abstract] [Full Text]  
• Escobar-Henriques, M., Collart, M. A., Daignan-Fornier, B. (2003). Transcription Initiation of the Yeast IMD2 Gene Is Abolished in Response to Nutrient Limitation through a Sequence in Its Coding Region. Mol. Cell. Biol. 23: 6279-6290 [Abstract] [Full Text]  
• Henry, M. F., Mandel, D., Routson, V., Henry, P. A. (2003). The Yeast hnRNP-like Protein Hrp1/Nab4 Accumulates in the Cytoplasm after Hyperosmotic Stress: A Novel Fps1-dependent Response. Mol. Biol. Cell 14: 3929-3941 [Abstract] [Full Text]  
• Kaplan, C. D., Laprade, L., Winston, F. (2003). Transcription Elongation Factors Repress Transcription Initiation from Cryptic Sites. Science 301: 1096-1099 [Abstract] [Full Text]  
• Kotovic, K. M., Lockshon, D., Boric, L., Neugebauer, K. M. (2003). Cotranscriptional Recruitment of the U1 snRNP to Intron-Containing Genes in Yeast. Mol. Cell. Biol. 23: 5768-5779 [Abstract] [Full Text]  
• Heikkinen, H. L., Llewellyn, S. A., Barnes, C. A. (2003). Initiation-mediated mRNA decay in yeast affects heat-shock mRNAs, and works through decapping and 5'-to-3' hydrolysis. Nucleic Acids Res 31: 4006-4016 [Abstract] [Full Text]  
• Farago, M., Nahari, T., Hammel, C., Cole, C. N., Choder, M. (2003). Rpb4p, a Subunit of RNA Polymerase II, Mediates mRNA Export during Stress. Mol. Biol. Cell 14: 2744-2755 [Abstract] [Full Text]  
• Narayanan, A., Eifert, J., Marfatia, K. A., Macara, I. G., Corbett, A. H., Terns, R. M., Terns, M. P. (2003). Nuclear RanGTP is not required for targeting small nucleolar RNAs to the nucleolus. J. Cell Sci. 116: 177-186 [Abstract] [Full Text]  
• Jablonowski, D., Schaffrath, R. (2002). Saccharomyces cerevisiae RNA Polymerase II Is Affected by Kluyveromyces lactis Zymocin. J. Biol. Chem. 277: 26276-26280 [Abstract] [Full Text]  
• Wang, Y., Liu, C. L., Storey, J. D., Tibshirani, R. J., Herschlag, D., Brown, P. O. (2002). Precision and functional specificity in mRNA decay. Proc. Natl. Acad. Sci. USA 99: 5860-5865 [Abstract] [Full Text]  
• Van Mullem, V., Wery, M., Werner, M., Vandenhaute, J., Thuriaux, P. (2002). The Rpb9 Subunit of RNA Polymerase II Binds Transcription Factor TFIIE and Interferes with the SAGA and Elongator Histone Acetyltransferases. J. Biol. Chem. 277: 10220-10225 [Abstract] [Full Text]  
• Green, D. M., Marfatia, K. A., Crafton, E. B., Zhang, X., Cheng, X., Corbett, A. H. (2002). Nab2p Is Required for Poly(A) RNA Export in Saccharomyces cerevisiae and Is Regulated by Arginine Methylation via Hmt1p. J. Biol. Chem. 277: 7752-7760 [Abstract] [Full Text]  
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• Miyao, T., Barnett, J. D., Woychik, N. A. (2001). Deletion of the RNA Polymerase Subunit RPB4 Acts as a Global, Not Stress-specific, Shut-off Switch for RNA Polymerase II Transcription at High Temperatures. J. Biol. Chem. 276: 46408-46413 [Abstract] [Full Text]  
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• Albig, A. R., Decker, C. J. (2001). The Target of Rapamycin Signaling Pathway Regulates mRNA Turnover in the Yeast Saccharomyces cerevisiae. Mol. Biol. Cell 12: 3428-3438 [Abstract] [Full Text]  
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• Briand, J.-F., Navarro, F., Gadal, O., Thuriaux, P. (2001). Cross Talk between tRNA and rRNA Synthesis in Saccharomyces cerevisiae. Mol. Cell. Biol. 21: 189-195 [Abstract] [Full Text]  
• Shaw, R. J., Reines, D. (2000). Saccharomyces cerevisiae Transcription Elongation Mutants Are Defective in PUR5 Induction in Response to Nucleotide Depletion. Mol. Cell. Biol. 20: 7427-7437 [Abstract] [Full Text]  
• Schroeder, S. C., Schwer, B., Shuman, S., Bentley, D. (2000). Dynamic association of capping enzymes with transcribing RNA polymerase II. Genes Dev. 14: 2435-2440 [Abstract] [Full Text]  
• Li, X., Bhaumik, S. R., Green, M. R. (2000). Distinct Classes of Yeast Promoters Revealed by Differential TAF Recruitment. Science 288: 1242-1244 [Abstract] [Full Text]  
• Prieto, S., de la Cruz, B. J., Scheffler, I. E. (2000). Glucose-regulated Turnover of mRNA and the Influence of Poly(A) Tail Length on Half-life. J. Biol. Chem. 275: 14155-14166 [Abstract] [Full Text]  
• Ashe, M. P., De Long, S. K., Sachs, A. B. (2000). Glucose Depletion Rapidly Inhibits Translation Initiation in Yeast. Mol. Biol. Cell 11: 833-848 [Abstract] [Full Text]  
• de Groot, E., Bebelman, J.-p., Mager, W. H., Planta, R. J. (2000). Very low amounts of glucose cause repression of the stress-responsive gene HSP12 in Saccharomyces cerevisiae. Microbiology 146: 367-375 [Abstract] [Full Text]  
• Rodriguez, C. R., Cho, E.-J., Keogh, M.-C., Moore, C. L., Greenleaf, A. L., Buratowski, S. (2000). Kin28, the TFIIH-Associated Carboxy-Terminal Domain Kinase, Facilitates the Recruitment of mRNA Processing Machinery to RNA Polymerase II. Mol. Cell. Biol. 20: 104-112 [Abstract] [Full Text]  
• Chou, S., Chatterjee, S., Lee, M., Struhl, K. (1999). Transcriptional Activation in Yeast Cells Lacking Transcription Factor IIA. Genetics 153: 1573-1581 [Abstract] [Full Text]  
• Moy, T. I., Silver, P. A. (1999). Nuclear export of the small ribosomal subunit requires the Ran-GTPase cycle and certain nucleoporins. Genes Dev. 13: 2118-2133 [Abstract] [Full Text]  
• Maillet, I., Buhler, J. M., Sentenac, A., Labarre, J. (1999). Rpb4p Is Necessary for RNA Polymerase II Activity at High Temperature. J. Biol. Chem. 274: 22586-22590 [Abstract] [Full Text]  
• Li, B., Nierras, C. R., Warner, J. R. (1999). Transcriptional Elements Involved in the Repression of Ribosomal Protein Synthesis. Mol. Cell. Biol. 19: 5393-5404 [Abstract] [Full Text]  
• Sanders, S. L., Klebanow, E. R., Weil, P. A. (1999). TAF25p, a Non-histone-like Subunit of TFIID and SAGA Complexes, Is Essential for Total mRNA Gene Transcription in Vivo. J. Biol. Chem. 274: 18847-18850 [Abstract] [Full Text]  
• Kimmelman, J., Kaldis, P., Hengartner, C. J., Laff, G. M., Koh, S. S., Young, R. A., Solomon, M. J. (1999). Activating Phosphorylation of the Kin28p Subunit of Yeast TFIIH by Cak1p. Mol. Cell. Biol. 19: 4774-4787 [Abstract] [Full Text]  
• Liu, Y., Guo, W., Tartakoff, P. Y., Tartakoff, A. M. (1999). A Crm1p-independent nuclear export path for the mRNA-associated protein, Npl3p/Mtr13p. Proc. Natl. Acad. Sci. USA 96: 6739-6744 [Abstract] [Full Text]  
• Lopez, N., Halladay, J., Walter, W., Craig, E. A. (1999). SSB, Encoding a Ribosome-Associated Chaperone, Is Coordinately Regulated with Ribosomal Protein Genes. J. Bacteriol. 181: 3136-3143 [Abstract] [Full Text]  
• Vu, L., Siddiqi, I., Lee, B.-S., Josaitis, C. A., Nomura, M. (1999). RNA polymerase switch in transcription of yeast rDNA: Role of transcription factor (upstream activation factor) in silencing rDNA transcription by RNA polymerase II. Proc. Natl. Acad. Sci. USA 96: 4390-4395 [Abstract] [Full Text]  
• Gadal, O., Shpakovski, G. V., Thuriaux, P. (1999). Mutants in ABC10beta , a Conserved Subunit Shared by All Three Yeast RNA Polymerases, Specifically Affect RNA Polymerase I Assembly. J. Biol. Chem. 274: 8421-8427 [Abstract] [Full Text]  
• Rosenheck, S., Choder, M. (1998). Rpb4, a Subunit of RNA Polymerase II, Enables the Enzyme To Transcribe at Temperature Extremes In Vitro. J. Bacteriol. 180: 6187-6192 [Abstract] [Full Text]  
• Brown, C. E., Sachs, A. B. (1998). Poly(A) Tail Length Control in Saccharomyces cerevisiae Occurs by Message-Specific Deadenylation. Mol. Cell. Biol. 18: 6548-6559 [Abstract] [Full Text]  
• Solsbacher, J., Maurer, P., Bischoff, F. R., Schlenstedt, G. (1998). Cse1p Is Involved in Export of Yeast Importin alpha  from the Nucleus. Mol. Cell. Biol. 18: 6805-6815 [Abstract] [Full Text]  
• Coller, J. M., Gray, N. K., Wickens, M. P. (1998). mRNA stabilization by poly(A) binding protein is independent of poly(A) and requires translation. Genes Dev. 12: 3226-3235 [Abstract] [Full Text]  
• McNeil, J. B., Agah, H., Bentley, D. (1998). Activated transcription independent of the RNA polymerase II holoenzyme in budding yeast. Genes Dev. 12: 2510-2521 [Abstract] [Full Text]  
• Schroeder, S. C., Weil, P. A. (1998). Genetic Tests of the Role of Abf1p in Driving Transcription of the Yeast TATA Box Bindng Protein-encoding Gene, SPT15. J. Biol. Chem. 273: 19884-19891 [Abstract] [Full Text]  
• Wang, K. L.-C., Warner, J. R. (1998). Positive and Negative Autoregulation of REB1 Transcription in Saccharomyces cerevisiae. Mol. Cell. Biol. 18: 4368-4376 [Abstract] [Full Text]  
• Shen, E. C., Henry, M. F., Weiss, V. H., Valentini, S. R., Silver, P. A., Lee, M. S. (1998). Arginine methylation facilitates the nuclear export of hnRNP proteins. Genes Dev. 12: 679-691 [Abstract] [Full Text]  
• Verdone, L., Cesari, F., Denis, C. L., Di Mauro, E., Caserta, M. (1997). Factors Affecting Saccharomyces cerevisiae ADH2 Chromatin Remodeling and Transcription. J. Biol. Chem. 272: 30828-30834 [Abstract] [Full Text]  
• Stutz, F., Kantor, J., Zhang, D., McCarthy, T., Neville, M., Rosbash, M. (1997). The yeast nucleoporin Rip1p contributes to multiple export pathways with no essential role for its FG-repeat region. Genes Dev. 11: 2857-2868 [Abstract] [Full Text]  
• Sakurai, H., Ohishi, T., Fukasawa, T. (1997). Promoter Structure-dependent Functioning of the General Transcription Factor IIE in Saccharomyces cerevisiae. J. Biol. Chem. 272: 15936-15942 [Abstract] [Full Text]  
• Linz, B., Koloteva, N., Vasilescu, S., McCarthy, J. E.G. (1997). Disruption of Ribosomal Scanning on the 5'-Untranslated Region, and Not Restriction of Translational Initiation per se, Modulates the Stability of Nonaberrant mRNAs in the Yeast Saccharomyces cerevisiae. J. Biol. Chem. 272: 9131-9140 [Abstract] [Full Text]  
• Gonzalez, C. I., Martin, C. E. (1996). Fatty Acid-responsive Control of mRNA Stability. UNSATURATED FATTY ACID-INDUCED DEGRADATION OF THE SACCHAROMYCES OLE1 TRANSCRIPT. J. Biol. Chem. 271: 25801-25809 [Abstract] [Full Text]  
• Apone, L M, Virbasius, C M, Reese, J C, Green, M R (1996). Yeast TAF(II)90 is required for cell-cycle progression through G2/M but not for general transcription activation.. Genes Dev. 10: 2368-2380 [Abstract]  
• Lee, M S, Henry, M, Silver, P A (1996). A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA export.. Genes Dev. 10: 1233-1246 [Abstract]  
• Oliveira, C. C., McCarthy, J. E. G. (1995). The Relationship between Eukaryotic Translation and mRNA Stability. J. Biol. Chem. 270: 8936-8943 [Abstract] [Full Text]  
• Roberts, S, Colbert, T, Hahn, S (1995). TFIIIC determines RNA polymerase III specificity at the TATA-containing yeast U6 promoter.. Genes Dev. 9: 832-842 [Abstract]  
• He, F, Jacobson, A (1995). Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen.. Genes Dev. 9: 437-454 [Abstract]  
• Singleton, D., Chen, S, Hitomi, M, Kumagai, C, Tartakoff, A. (1995). A yeast protein that bidirectionally affects nucleocytoplasmic transport. J. Cell Sci. 108: 265-272 [Abstract]  
• Qiu, H, Park, E, Prakash, L, Prakash, S (1993). The Saccharomyces cerevisiae DNA repair gene RAD25 is required for transcription by RNA polymerase II.. Genes Dev. 7: 2161-2171 [Abstract]  
• Peltz, S W, Brown, A H, Jacobson, A (1993). mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor.. Genes Dev. 7: 1737-1754 [Abstract]  
• Giardina, C, Lis, J. (1993). DNA melting on yeast RNA polymerase II promoters. Science 261: 759-762 [Abstract]  
• Decker, C J, Parker, R (1993). A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.. Genes Dev. 7: 1632-1643 [Abstract]  
• Forrester, W, Stutz, F, Rosbash, M, Wickens, M (1992). Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure.. Genes Dev. 6: 1914-1926 [Abstract]  
• Amberg, D C, Goldstein, A L, Cole, C N (1992). Isolation and characterization of RAT1: an essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.. Genes Dev. 6: 1173-1189 [Abstract]  
• Leeds, P, Peltz, S W, Jacobson, A, Culbertson, M R (1991). The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.. Genes Dev. 5: 2303-2314 [Abstract]  
• Lim, C. R., Kimata, Y., Ohdate, H., Kokubo, T., Kikuchi, N., Horigome, T., Kohno, K. (2000). The Saccharomyces cerevisiae RuvB-like Protein, Tih2p, Is Required for Cell Cycle Progression and RNA Polymerase II-directed Transcription. J. Biol. Chem. 275: 22409-22417 [Abstract] [Full Text]  
• Shaw, R. J., Wilson, J. L., Smith, K. T., Reines, D. (2001). Regulation of an IMP Dehydrogenase Gene and Its Overexpression in Drug-sensitive Transcription Elongation Mutants of Yeast. J. Biol. Chem. 276: 32905-32916 [Abstract] [Full Text]  
• Wang, Y., Liu, C. L., Storey, J. D., Tibshirani, R. J., Herschlag, D., Brown, P. O. (2002). Precision and functional specificity in mRNA decay. Proc. Natl. Acad. Sci. USA 99: 5860-5865 [Abstract] [Full Text]