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Mol Cell Biol. 1987 July; 7(7): 2610-2613

Transient expression of foreign genes in lymphoid cells is enhanced by phorbol ester.

N J Holbrook, J D Luethy and J Kin

ABSTRACT

In lymphoid cells and an erythroleukemia cell line, phorbol myristate acetate significantly enhanced (up to 90-fold) expression of chloramphenicol acetyltransferase driven by four unrelated viral transcriptional units. The results suggest that phorbol myristate acetate acts via a general mechanism to enhance gene expression in these cells and provides a convenient means for increasing transient expression of foreign DNA.

Mol Cell Biol. 1987 July; 7(7): 2610-2613




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